ASCP HEMATOLOGY UPDATED EXAM SCRIPT QUESTIONS
AND ANSWERS GRADED A+
✔✔Which of the following characteristics are common to hereditary spherocytosis,
hereditary elliptocytosis, hereditary stomatocytosis, and paroxysmal nocturnal
hemoglobinuria?
A. autosomal dominant inheritance
B. red cell membrane defects
C. positive direct anti-globulin test
D. measured platelet count - ✔✔B. red cell membrane defects
✔✔Which of the following is most closely associated with iron deficiency anemia?
A. iron overload in tissue
B. target cells
C. basophilic stippling
D. chronic blood loss - ✔✔D. chronic blood loss
✔✔Evidence indicates that the generic defect in thalassemia usually results in?
A. the production of abnormal globin class
B. a quantitative deficiency in RNA resulting in decreased globin chain production
C. a structured change in the heme portion of the hemoglobin
D. an abnormality in the alpha- or beta-chain binding or affinity - ✔✔B. a quantitative
deficiency in RNA resulting in decreased globin chain production
✔✔An enzyme deficiency assciated with moderate to sever hemolytic anemia after the
patient is exposed to certain drugs and characteristized by red cell inclusions formed by
denatured hemoglobin is:
A. lactate dehydrogenase deficiency
B. G-6-PD deficiency
C. pyruvate kinase deficiency
D. hexokinase deficiency - ✔✔B. G-6-PD deficiency
✔✔Patients with A(-) type G-6-PD deficiency are least likely to have hemolytic episodes
in which of the following situations?
A. following administration of oxidizing drugs
B. following ingestion of fava beans
C. during infections
D. spontaneously - ✔✔D. spontaneously
, ✔✔A patient has a congenital nonspherocytic hemolytic anemia. After exposure to anti-
malarial drugs, the patient experiences a severe hemolytic episode. This episode is
characterized by red cell inclusions caused by hemoglobin denaturation. Which of the
following conditions is most consistent with these findings?
A. G-6-PD deficiency
B. thalassemia major
C. pyruvate kinase deficiency
D. paroxysmal nocturnal hemoglobinuria - ✔✔A. G-6-PD deficiency
✔✔Peripheral blood smears from patients with untreated pernicious anemia are
characterized by:
A. pancytopenia and macrocytosis
B. leukocytosis and elliptocytosis
C. leukocytosis and ovalocytosis
D. pancytopenia and microcytosis - ✔✔A. pancytopenia and macrocytosis
✔✔Laboratory tests performed on a patient indicate macrocytosis, anemia, leukopenia,
and thrombocytopenia. Which of the following disorders is the patient most likely to
have?
A. anemia of chronic disorder
B. vitamin B12 deficiency
C. iron deficiency
D. acute hemorrhage - ✔✔B. vitamin B12 deficiency
✔✔The characteristic morphological feature in folic acid deficiency is:
A. macrocytosis
B. target cells
C. basophilic stippling
D. rouleax formation - ✔✔A. macrocytosis
✔✔The most likely cause of the macrocytosis that often accompanies anemia of
myelofibrosis is:
A. folic acid deficiency
B. increased reticulocyte count
C. inadequate B12 absorption
D. pyroxine deficiency - ✔✔A. folic acid deficiency
✔✔A characteristic morphologic feature in hemoglobin C disease is:
A. macrocytosis
AND ANSWERS GRADED A+
✔✔Which of the following characteristics are common to hereditary spherocytosis,
hereditary elliptocytosis, hereditary stomatocytosis, and paroxysmal nocturnal
hemoglobinuria?
A. autosomal dominant inheritance
B. red cell membrane defects
C. positive direct anti-globulin test
D. measured platelet count - ✔✔B. red cell membrane defects
✔✔Which of the following is most closely associated with iron deficiency anemia?
A. iron overload in tissue
B. target cells
C. basophilic stippling
D. chronic blood loss - ✔✔D. chronic blood loss
✔✔Evidence indicates that the generic defect in thalassemia usually results in?
A. the production of abnormal globin class
B. a quantitative deficiency in RNA resulting in decreased globin chain production
C. a structured change in the heme portion of the hemoglobin
D. an abnormality in the alpha- or beta-chain binding or affinity - ✔✔B. a quantitative
deficiency in RNA resulting in decreased globin chain production
✔✔An enzyme deficiency assciated with moderate to sever hemolytic anemia after the
patient is exposed to certain drugs and characteristized by red cell inclusions formed by
denatured hemoglobin is:
A. lactate dehydrogenase deficiency
B. G-6-PD deficiency
C. pyruvate kinase deficiency
D. hexokinase deficiency - ✔✔B. G-6-PD deficiency
✔✔Patients with A(-) type G-6-PD deficiency are least likely to have hemolytic episodes
in which of the following situations?
A. following administration of oxidizing drugs
B. following ingestion of fava beans
C. during infections
D. spontaneously - ✔✔D. spontaneously
, ✔✔A patient has a congenital nonspherocytic hemolytic anemia. After exposure to anti-
malarial drugs, the patient experiences a severe hemolytic episode. This episode is
characterized by red cell inclusions caused by hemoglobin denaturation. Which of the
following conditions is most consistent with these findings?
A. G-6-PD deficiency
B. thalassemia major
C. pyruvate kinase deficiency
D. paroxysmal nocturnal hemoglobinuria - ✔✔A. G-6-PD deficiency
✔✔Peripheral blood smears from patients with untreated pernicious anemia are
characterized by:
A. pancytopenia and macrocytosis
B. leukocytosis and elliptocytosis
C. leukocytosis and ovalocytosis
D. pancytopenia and microcytosis - ✔✔A. pancytopenia and macrocytosis
✔✔Laboratory tests performed on a patient indicate macrocytosis, anemia, leukopenia,
and thrombocytopenia. Which of the following disorders is the patient most likely to
have?
A. anemia of chronic disorder
B. vitamin B12 deficiency
C. iron deficiency
D. acute hemorrhage - ✔✔B. vitamin B12 deficiency
✔✔The characteristic morphological feature in folic acid deficiency is:
A. macrocytosis
B. target cells
C. basophilic stippling
D. rouleax formation - ✔✔A. macrocytosis
✔✔The most likely cause of the macrocytosis that often accompanies anemia of
myelofibrosis is:
A. folic acid deficiency
B. increased reticulocyte count
C. inadequate B12 absorption
D. pyroxine deficiency - ✔✔A. folic acid deficiency
✔✔A characteristic morphologic feature in hemoglobin C disease is:
A. macrocytosis
