ASCP HEMATOLOGY 2026 TEST PAPER QUESTIONS AND
ANSWERS GRADED A+
✔✔Ham's/Acid Hemolysis testing measures? - ✔✔complement mediated lysis
✔✔The sucrose hemolysis test measures? - ✔✔the effect of complement (activated by
sucrose) on RBCs
✔✔Heinz body preps measure? - ✔✔the effect of oxidizing agents on hemoglobin.
✔✔A heinz body prep can indicate what conditions? - ✔✔G6PD deficiency, unstable
hemoglobins, HbH
✔✔Anti-malarial drugs and fava beans can exacerbate what condition? - ✔✔G6PD
deficiency
✔✔A sickle cell screen measures? - ✔✔the reduced solubility of deoxygenated
hemoglobin S
✔✔A kleihauer-betke acid elution measures? - ✔✔the resistance of fetal hemoglobin to
acid elution
✔✔Kleihauer-betke acid elution testing can indicate what conditions? - ✔✔FMH,
hereditary persistence of fetal hemoglobin
✔✔A cold agglutinin screen determines? - ✔✔the presence of a cold autoantibody
✔✔What is the name of the condition that is related to an overall increase in the number
of RBCs? - ✔✔polycythemia
✔✔In relative polycythemia, a decrease in what leads to the relative increase in RBCs?
- ✔✔plasma
✔✔In what type of polycythemia is there a decrease in EPO with normal O2 saturation?
- ✔✔primary (vera)
✔✔In what type of polycythemia is there an increase in EPO with a decrease in O2
saturation? - ✔✔secondary
✔✔Alder-Reilly is an anomaly which is characterized by? - ✔✔large azurophilic
granules (due to the increased presence of mucopolysaccharides)
, ✔✔The chediak-higashi condition is characterized by? - ✔✔large lysosomes (they are
the result of the fusion of primary granules)
✔✔Individuals with the chediak-higashi condition are susceptible to? - ✔✔infections
✔✔The May-Hegglin anomaly is characterized by? - ✔✔cytoplasmic inclusions of RNA
resembling dohle bodies (this condition may also affect platelets leading to bleeding
tendencies, leukocyte function is not altered)
✔✔The pelger-Huet condition is characterized by? - ✔✔hyposegmented neutrophils
(leukocyte function is not altered)
✔✔Myelodysplastic syndromes are neoplastic, clonal, stem cell disorder that are
characterized by? - ✔✔cytopenias, bone marrow dyspoiesis
✔✔What are the four major categories of myelodysplastic syndromes? - ✔✔RA, RARS,
RAEB, CMML
✔✔Refractory anemia (with ringed sideroblasts too) is characterized by? - ✔✔<5% type
I and II blasts present in the bone marrow
✔✔Refractory anemia with excess blasts is characterized by? - ✔✔<5% blasts in
peripheral blood, 5-10% blasts of type I and II found in the bone marrow (if above 20%
of blasts it is diagnosed as a leukemia)
✔✔Myeloproliferative disorders are neoplastic, clonal disorders that are characterized
by? - ✔✔increases in RBCs,WBCs, and/or platelets
✔✔What lab findings are commonly seen in individuals with idiopathic myelofibrosis? -
✔✔dry tap, dacrocytes, bone marrow fibrosis
✔✔What lab findings are commonly seen in individuals with essential
thrombocytopenia? - ✔✔increase in megakaryocytes in bone marrow, very high platelet
count (1000-5000)
✔✔What lab findings are commonly seen in individuals with chronic myelocytic
leukemia? - ✔✔increase in myelocytic precursors, decreased LAP score, ph
chomosome
✔✔In a leukemoid reaction, the LAP score is? - ✔✔increased
✔✔In CML, the LAP score is? - ✔✔decreased
ANSWERS GRADED A+
✔✔Ham's/Acid Hemolysis testing measures? - ✔✔complement mediated lysis
✔✔The sucrose hemolysis test measures? - ✔✔the effect of complement (activated by
sucrose) on RBCs
✔✔Heinz body preps measure? - ✔✔the effect of oxidizing agents on hemoglobin.
✔✔A heinz body prep can indicate what conditions? - ✔✔G6PD deficiency, unstable
hemoglobins, HbH
✔✔Anti-malarial drugs and fava beans can exacerbate what condition? - ✔✔G6PD
deficiency
✔✔A sickle cell screen measures? - ✔✔the reduced solubility of deoxygenated
hemoglobin S
✔✔A kleihauer-betke acid elution measures? - ✔✔the resistance of fetal hemoglobin to
acid elution
✔✔Kleihauer-betke acid elution testing can indicate what conditions? - ✔✔FMH,
hereditary persistence of fetal hemoglobin
✔✔A cold agglutinin screen determines? - ✔✔the presence of a cold autoantibody
✔✔What is the name of the condition that is related to an overall increase in the number
of RBCs? - ✔✔polycythemia
✔✔In relative polycythemia, a decrease in what leads to the relative increase in RBCs?
- ✔✔plasma
✔✔In what type of polycythemia is there a decrease in EPO with normal O2 saturation?
- ✔✔primary (vera)
✔✔In what type of polycythemia is there an increase in EPO with a decrease in O2
saturation? - ✔✔secondary
✔✔Alder-Reilly is an anomaly which is characterized by? - ✔✔large azurophilic
granules (due to the increased presence of mucopolysaccharides)
, ✔✔The chediak-higashi condition is characterized by? - ✔✔large lysosomes (they are
the result of the fusion of primary granules)
✔✔Individuals with the chediak-higashi condition are susceptible to? - ✔✔infections
✔✔The May-Hegglin anomaly is characterized by? - ✔✔cytoplasmic inclusions of RNA
resembling dohle bodies (this condition may also affect platelets leading to bleeding
tendencies, leukocyte function is not altered)
✔✔The pelger-Huet condition is characterized by? - ✔✔hyposegmented neutrophils
(leukocyte function is not altered)
✔✔Myelodysplastic syndromes are neoplastic, clonal, stem cell disorder that are
characterized by? - ✔✔cytopenias, bone marrow dyspoiesis
✔✔What are the four major categories of myelodysplastic syndromes? - ✔✔RA, RARS,
RAEB, CMML
✔✔Refractory anemia (with ringed sideroblasts too) is characterized by? - ✔✔<5% type
I and II blasts present in the bone marrow
✔✔Refractory anemia with excess blasts is characterized by? - ✔✔<5% blasts in
peripheral blood, 5-10% blasts of type I and II found in the bone marrow (if above 20%
of blasts it is diagnosed as a leukemia)
✔✔Myeloproliferative disorders are neoplastic, clonal disorders that are characterized
by? - ✔✔increases in RBCs,WBCs, and/or platelets
✔✔What lab findings are commonly seen in individuals with idiopathic myelofibrosis? -
✔✔dry tap, dacrocytes, bone marrow fibrosis
✔✔What lab findings are commonly seen in individuals with essential
thrombocytopenia? - ✔✔increase in megakaryocytes in bone marrow, very high platelet
count (1000-5000)
✔✔What lab findings are commonly seen in individuals with chronic myelocytic
leukemia? - ✔✔increase in myelocytic precursors, decreased LAP score, ph
chomosome
✔✔In a leukemoid reaction, the LAP score is? - ✔✔increased
✔✔In CML, the LAP score is? - ✔✔decreased
