Ascp Hematology 2026 Core Exam Test Questions And Answers Graded A+

ASCP HEMATOLOGY 2026 CORE EXAM TEST QUESTIONS
AND ANSWERS GRADED A+
✔✔Etiology:
Enzymatic defect in heme synthesis. - ✔✔Sideroblastic Anemia

-RBC indices usually normal.
Ringed sideroblasts in marrow.

✔✔Etiology:
Little or no Hgb A, 95%-98% F, 2%-5% A2.
Severe anemia. MCV <67 fL. - ✔✔Beta-thalassemia Major

✔✔Etiology:
Heterozygous >90%-95% Hgb A, 3.5%-7% A2, 2%-5% F.
Mild anemia. - ✔✔Beta-thalassemia minor

✔✔Etiology:
Acute phase reactants (e.g., hepcidin) affect iron absorption & release.
Iron in bone marrow macrophages is not
released to developing RBCs. - ✔✔Anemia of chronic inflammation/disease

-Associated with chronic infections & inflammation, -malignancies, autoimmune
diseases.
-2nd most common anemia after IDA.
-Most common anemia in hospitalized pts.

✔✔Iron deficiency anemia
1. RBC
2. RDW
3. Serum Iron
4. TIBC
5. Serum Ferritin
6. Hgb A2 - ✔✔Iron deficiency anemia: microcytic,hypochromic
1. RBC-Decrease
2. RDW-Increase
3. Serum Iron-Decrease
4. TIBC-Increase
5. Serum Ferritin-Decrease
6. Hgb A2-Normal

✔✔Sideroblastic anemia
1. RBC
2. RDW
3. Serum Iron

,4. TIBC
5. Serum Ferritin
6. Hgb A - ✔✔Sideroblastic anemia: microcytic, hypochromic
1. RBC-Decrease
2. RDW-Increase
3. Serum Iron-Increase
4. TIBC-Normal
5. Serum Ferritin-Increase
6. Hgb A2-Normal

✔✔What type of Anemia:
A disruption in normal hemoglobin production. Your body tries to make up for the
shortage of hemoglobin by absorbing more iron from food - ✔✔Type: Sideroblastic
Anemia

✔✔β -thalassemia minor
1. RBC
2. RDW
3. Serum Iron
4. TIBC
5. Serum Ferritin
6. Hgb A - ✔✔β -thalassemia minor
1. RBC-Increase
2. RDW-N
3. Serum Iron-N
4. TIBC-N
5. Serum Ferritin-N
6. Hgb A-Increase

✔✔Anemia of chronic inflammation
1. RBC
2. RDW
3. Serum Iron
4. TIBC
5. Serum Ferritin
6. Hgb A - ✔✔Anemia of chronic inflammation
1. RBC-Decrease
2. RDW-Normal
3. Serum Iron-Decrease
4. TIBC-Decrease
5. Serum Ferritin-Increase
6. Hgb A-Normal

✔✔In anemia of inflammation, the body does not recycle --- as easily, so it is "held up"
in cells such as --- -. There is also decreased iron absorption from the intestines. These

, changes are caused by a protein called ------. - ✔✔In anemia of inflammation, the body
does not recycle iron as easily, so it is "held up" in cells such as macrophages (a type of
white blood cell). There is also decreased iron absorption from the intestines. These
changes are caused by a protein called hepcidin.

✔✔List the stages of Granulocytic Maturation:
1.
2.
3.
4.
5.
6. - ✔✔List the stages of Granulocytic Maturation:
1. Myeloblast
2. Promyelocyte
3. Myelocyte
4. Metamyelocyte
5. Band
6. Segmented Neutrophil

✔✔Image: Myeloblast - ✔✔

✔✔Image: Has primary (nonspecific) granules. - ✔✔Promyelocyte
-Primary Granules (red/purple)
-Promyelocytes are generally larger than myeloblasts, measuring approximately 12 to
20 microns.

✔✔Image: Secondary (specific) granules (eosinophilic, basophilic, or neutrophilic).
Last stage to divide - ✔✔Myelocyte
While the cytoplasm shifts to producing secondary granules it also looses the
prominence of its primary granules.
-Blue Arrow

✔✔Image: Nucleus begins to indent. - ✔✔Metamyelocyte

✔✔Image: Nuclear indentation is more than half. - ✔✔Band

✔✔Image: 2-55 nuclear lobes connected by thin strands of chromatin. - ✔✔Segmented
Neutrophil

✔✔Leukocyte Abnormalities:
Pesence of immature granulocytes in peripheral blood - ✔✔Shift to the left

✔✔A shift to the left is seen in ---infection and ----. - ✔✔A shift to the left is seen in
bacterial infection and inflammation.