, Test Bank dt
to accompany
dt
Psychopharmacology, Third Edition dt dt
Meyer • Quenzer dt dt
Chapter 1: Principles of Pharmacology dt dt dt dt
Multiple Choice dt
1. dt
refer(s) to specific molecular changes that occur when a drug binds to a particular targ
dt dt dt dt dt dt dt dt dt dt dt dt dt dt
et site or receptor, while
dt dt dt dt
are the resulting widespread alterationsin function.
dt dt dt dt dt dt
a. Drug action; therapeutic effects dt dt dt
b. Side effects; drug effects dt dt dt
c. Therapeutic effects; side effects dt dt dt
d. Drug action; drug effects dt dt dt
Answer: d dt
Textbook Reference: Pharmacology: The Science of Drug Action
dt dt dt dt dt dt dt
2. After drug administration has occurred, the amount of drug in the blood that is free tobi
dt dt dt dt dt dt dt dt dt dt dt dt dt dt dt dt
nd at specific target sites is referred to as
dt dt dt dt dt dt dt dt
a. the therapeutic dose.
dt dt
b. first-pass effects. dt
c. bioavailability.
d. ED50.
Answer: c dt
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
dt dt dt dt dt dt
3. The specific molecular changes that occur when a drug binds to a particular target siteor
dt dt dt dt dt dt dt dt dt dt dt dt dt dt dt
receptor are referred to as
dt dt dt dt dt
a. drug effects. dt
b. drug action. dt
c. side effects. dt
d. placebo effects. dt
Answer: b dt
Textbook Reference: Pharmacology: The Science of Drug Action
dt dt dt dt dt dt dt
4. Which of the following is not a possible explanation for placebo effects?
dt dt dt dt dt dt dt dt dt dt dt
a. Pavlovian conditioning dt
b. Genetic variation dt
c. Drug competition dt
d. Expectation of outcome dt dt
Answer: c dt
Textbook Reference: Pharmacology: The Science of Drug Action
dt dt dt dt dt dt dt
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dt dt dt
,5. The administration of oxytocin has been proposed as a treatment for autism. dt dt dt dt dt dt dt dt dt dt
a. intravenous
b. oral
c. intranasal
d. intracerebral
Answer: c dt
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
dt dt dt dt dt dt
6. Which factor does not affect the pharmacokinetics of a drug?
dt dt dt dt dt dt dt dt dt
a. Route of administration
dt dt
b. Lipid solubility
dt
c. Depot binding dt
d. Drug action dt
Answer: d dt
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
dt dt dt dt dt dt
7. First-pass metabolism occurs when drugs are taken
dt dt dt dt dt dt
a. orally.
b. intravenously.
c. subcutaneously.
d. nasally.
Answer: a dt
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
dt dt dt dt dt dt
8. The area postrema is one area in the brain where the
dt dt is not complete. dt dt dt dt dt dt dt dt dt dt
a. cerebrospinal fluid dt
b. blood–brain barrier dt
c. choroid plexus dt
d. phospholipid membrane dt
Answer: b dt
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
dt dt dt dt dt dt
9. First-pass metabolism occurs with orally administered drugs because
dt dt dt dt dt dt dt
a. their absorption is slowed by food.
dt dt dt dt dt
b. drugs absorbed into the bloodstream from the stomach go to the liver on the way tog
dt dt dt dt dt dt dt dt dt dt dt dt dt dt dt dt
eneral circulation.
dt
c. drugs must first survive the acidic environment of the stomach.
dt dt dt dt dt dt dt dt dt
d. salivary enzymes in the mouth begin the process of metabolism.
dt dt dt dt dt dt dt dt dt
Answer: b dt
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
dt dt dt dt dt dt
10. Toxic substances in the blood trigger a vomiting response by activating the
dt dt dt dt dt dt dt dt dt dt dt
a. blood–brain barrier. dt
b. choroid plexus. dt
c. area postrema.
dt
d. median eminence. dt
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Page 2 of 247
dt dt dt
, Answer: c dt
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
dt dt dt dt dt dt
11. Drugs administered _ have the most rapid onset of action.
dt dt dt dt dt dt dt dt
a. subcutaneously
b. intramuscularly
c. orally
d. intravenously
Answer: d dt
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
dt dt dt dt dt dt
12. Ionization of a drug depends on the of the solution and the
dt dt dt dt dt dt dt dt dt dt
of thedrug.
dt dt
a. pH; pKadt
b. pKa; pH dt
c. concentration; lipid solubility dt dt
d. pH; concentration
dt
Answer: a dt
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
dt dt dt dt dt dt
13. The absorption of a drug depends on all of the following except
dt dt dt dt dt dt dt dt dt dt dt
a. lipid solubility.
dt
b. ionization.
c. body temperature. dt
d. the concentration of the drug.
dt dt dt dt
Answer: c dt
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
dt dt dt dt dt dt
14. Drugs that are should be avoided by women of childbearing age.
dt dt dt dt dt dt dt dt dt
a. teratogenic
b. able to cross the placental barrier
dt dt dt dt dt
c. psychoactive
d. highly lipid-soluble dt
Answer: a dt
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
dt dt dt dt dt dt
15. Agents that induce developmental abnormalities in a fetus are known as
dt dt dt dt dt dt dt dt dt dt
a. psychoactive drugs. dt
b. illicit drugs. dt
c. teratogens.
d. placental drugs. dt
Answer: c dt
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
dt dt dt dt dt dt
16. Depot binding is said to occur when drugs
dt dt dt dt dt dt dt
a. bind to their target sites.
dt dt dt dt
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dt dt dt
to accompany
dt
Psychopharmacology, Third Edition dt dt
Meyer • Quenzer dt dt
Chapter 1: Principles of Pharmacology dt dt dt dt
Multiple Choice dt
1. dt
refer(s) to specific molecular changes that occur when a drug binds to a particular targ
dt dt dt dt dt dt dt dt dt dt dt dt dt dt
et site or receptor, while
dt dt dt dt
are the resulting widespread alterationsin function.
dt dt dt dt dt dt
a. Drug action; therapeutic effects dt dt dt
b. Side effects; drug effects dt dt dt
c. Therapeutic effects; side effects dt dt dt
d. Drug action; drug effects dt dt dt
Answer: d dt
Textbook Reference: Pharmacology: The Science of Drug Action
dt dt dt dt dt dt dt
2. After drug administration has occurred, the amount of drug in the blood that is free tobi
dt dt dt dt dt dt dt dt dt dt dt dt dt dt dt dt
nd at specific target sites is referred to as
dt dt dt dt dt dt dt dt
a. the therapeutic dose.
dt dt
b. first-pass effects. dt
c. bioavailability.
d. ED50.
Answer: c dt
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
dt dt dt dt dt dt
3. The specific molecular changes that occur when a drug binds to a particular target siteor
dt dt dt dt dt dt dt dt dt dt dt dt dt dt dt
receptor are referred to as
dt dt dt dt dt
a. drug effects. dt
b. drug action. dt
c. side effects. dt
d. placebo effects. dt
Answer: b dt
Textbook Reference: Pharmacology: The Science of Drug Action
dt dt dt dt dt dt dt
4. Which of the following is not a possible explanation for placebo effects?
dt dt dt dt dt dt dt dt dt dt dt
a. Pavlovian conditioning dt
b. Genetic variation dt
c. Drug competition dt
d. Expectation of outcome dt dt
Answer: c dt
Textbook Reference: Pharmacology: The Science of Drug Action
dt dt dt dt dt dt dt
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Page 1 of 247
dt dt dt
,5. The administration of oxytocin has been proposed as a treatment for autism. dt dt dt dt dt dt dt dt dt dt
a. intravenous
b. oral
c. intranasal
d. intracerebral
Answer: c dt
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
dt dt dt dt dt dt
6. Which factor does not affect the pharmacokinetics of a drug?
dt dt dt dt dt dt dt dt dt
a. Route of administration
dt dt
b. Lipid solubility
dt
c. Depot binding dt
d. Drug action dt
Answer: d dt
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
dt dt dt dt dt dt
7. First-pass metabolism occurs when drugs are taken
dt dt dt dt dt dt
a. orally.
b. intravenously.
c. subcutaneously.
d. nasally.
Answer: a dt
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
dt dt dt dt dt dt
8. The area postrema is one area in the brain where the
dt dt is not complete. dt dt dt dt dt dt dt dt dt dt
a. cerebrospinal fluid dt
b. blood–brain barrier dt
c. choroid plexus dt
d. phospholipid membrane dt
Answer: b dt
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
dt dt dt dt dt dt
9. First-pass metabolism occurs with orally administered drugs because
dt dt dt dt dt dt dt
a. their absorption is slowed by food.
dt dt dt dt dt
b. drugs absorbed into the bloodstream from the stomach go to the liver on the way tog
dt dt dt dt dt dt dt dt dt dt dt dt dt dt dt dt
eneral circulation.
dt
c. drugs must first survive the acidic environment of the stomach.
dt dt dt dt dt dt dt dt dt
d. salivary enzymes in the mouth begin the process of metabolism.
dt dt dt dt dt dt dt dt dt
Answer: b dt
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
dt dt dt dt dt dt
10. Toxic substances in the blood trigger a vomiting response by activating the
dt dt dt dt dt dt dt dt dt dt dt
a. blood–brain barrier. dt
b. choroid plexus. dt
c. area postrema.
dt
d. median eminence. dt
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Page 2 of 247
dt dt dt
, Answer: c dt
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
dt dt dt dt dt dt
11. Drugs administered _ have the most rapid onset of action.
dt dt dt dt dt dt dt dt
a. subcutaneously
b. intramuscularly
c. orally
d. intravenously
Answer: d dt
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
dt dt dt dt dt dt
12. Ionization of a drug depends on the of the solution and the
dt dt dt dt dt dt dt dt dt dt
of thedrug.
dt dt
a. pH; pKadt
b. pKa; pH dt
c. concentration; lipid solubility dt dt
d. pH; concentration
dt
Answer: a dt
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
dt dt dt dt dt dt
13. The absorption of a drug depends on all of the following except
dt dt dt dt dt dt dt dt dt dt dt
a. lipid solubility.
dt
b. ionization.
c. body temperature. dt
d. the concentration of the drug.
dt dt dt dt
Answer: c dt
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
dt dt dt dt dt dt
14. Drugs that are should be avoided by women of childbearing age.
dt dt dt dt dt dt dt dt dt
a. teratogenic
b. able to cross the placental barrier
dt dt dt dt dt
c. psychoactive
d. highly lipid-soluble dt
Answer: a dt
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
dt dt dt dt dt dt
15. Agents that induce developmental abnormalities in a fetus are known as
dt dt dt dt dt dt dt dt dt dt
a. psychoactive drugs. dt
b. illicit drugs. dt
c. teratogens.
d. placental drugs. dt
Answer: c dt
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
dt dt dt dt dt dt
16. Depot binding is said to occur when drugs
dt dt dt dt dt dt dt
a. bind to their target sites.
dt dt dt dt
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dt dt dt