ANCC IQ Domain 1 Comprehensive Questions With
Correct Answers And Rationales Updated 2026
AsKaKPMHNP,KyouKareKawareKofKantipsychoticKmedicationKsideKeffects.KWhichKofKtheKfollowingKs
ideKeffectsKofKantipsychoticKmedicationsKhasKanKinsidious,Kdelayed-
onsetKtypicallyK1KtoK2KyearsKafterKinitiationKofKtheKmedication?
a.KDryKmouth
b.KTardiveKdyskinesia
c.KSedation
d.KWeightKgainK-KCORRECTKANSWERK-B
InKevaluatingKaK4-year-
old,KoneKwouldKexpectKwhichKofKtheKfollowingKdelaysKinKAsperger'sKDisorder?
a.KLanguageKdevelopment
b.KCognitiveKdevelopment
c.KMotorKskillsKcoordination
d.KSocialKskillsKdevelopmentK-KCORRECTKANSWERK-D
WhichKareaKofKtheKbrainKhasKbeenKimplicatedKtoKmodulateKpainKandKcanKhelpKexplainKhowKtranscr
anialKmagneticKstimulationKcanKhelpKdecreaseKpain?
a.KPrefrontalKcortex
b.KInsulaKcortex
c.KDorsolateralKprefrontalKcortex
d.KAnteriorKcingulateKcortexK-KCORRECTKANSWERK-A
WhichKofKtheKfollowingKantidepressantsKisKassociatedKwithKdose-
relatedKcardiovascularKadverseKeffectsKwhichKrequireKadherenceKtoKmaximumKrecommendedKdosi
ng,KunlessKhigherKdosesKareKdeemedKappropriateKdespiteKrisks?
a.KCitalopramK(Celexa)
, b.KVenlafaxineK(Effexor)
c.KMirtazapineK(Remeron)
d.KSertralineK(Zoloft)K-KCORRECTKANSWERK-A
WhichKofKtheKfollowingKfindingsKwouldKraiseKconcernKinKanKannualKsportsKexamKforKaK15-year-
oldKgirl?
a.KScarKtissueKfromKhymenalKtearKatK11Ko'clockK(reportedKbikingKinjury)
b.KBloodKpressureK86/56
c.KHeightK67Kinches,KweightK102Kpounds
d.KPulseK60,KrespirationsK26K-KCORRECTKANSWERK-C
AKweekKafterKraisingKtheKdoseKofKrisperidoneK(Risperdal),KaKpatientKtreatedKforKschizophreniaKpre
sentsKtoKtheKclinicKwithKreportsKofKanKacuteKchangeKinKmentalKstatus,Kfever,KandKrigidity.KAsKtheKtr
eatingKPMHNP,KyouKknowKtheseKsymptomsKareKconsistentKwithKwhichKofKtheKfollowing?
a.KNeurolepticKmalignantKsyndromeK(NMS)
b.KAnticholinergicKwithdrawalKsyndrome
c.KExtrapyramidalKsideKeffects
d.KSerotoninKsyndromeK-KCORRECTKANSWERK-A
WhichKofKtheKfollowingKstatementsKregardingKdisulfiramK(AntabuseKisKcorrect?
a.KDisulfiramKshouldKnotKbeKtakenKforKatKleastK6KhoursKafterKdrinkingKalcohol.
b.KAvoidKanythingKcontainingKalcoholK(i.e.,Kvinegar,Kmouthwash,Kaftershave,KcoughKmedication)K
whileKusingKdisulfiramKandKforK2KweeksKafterKdiscontinuing.
c.KAKdisulfiram-alcoholKreactionKcanKoccurKupKtoK1KweekKafterKdiscontinuingKdisulfiram.
d.KDisulfiramKcanKlowerKliverKfunctionKtestsKsoKmonitoringKisKnecessary.K-
KCORRECTKANSWERK-B
WhichKmoodKstabilizerKisKmostKassociatedKwithKaKpotentiallyKlife-threateningKrash?
a.KDivalproexK(Depakote)
Correct Answers And Rationales Updated 2026
AsKaKPMHNP,KyouKareKawareKofKantipsychoticKmedicationKsideKeffects.KWhichKofKtheKfollowingKs
ideKeffectsKofKantipsychoticKmedicationsKhasKanKinsidious,Kdelayed-
onsetKtypicallyK1KtoK2KyearsKafterKinitiationKofKtheKmedication?
a.KDryKmouth
b.KTardiveKdyskinesia
c.KSedation
d.KWeightKgainK-KCORRECTKANSWERK-B
InKevaluatingKaK4-year-
old,KoneKwouldKexpectKwhichKofKtheKfollowingKdelaysKinKAsperger'sKDisorder?
a.KLanguageKdevelopment
b.KCognitiveKdevelopment
c.KMotorKskillsKcoordination
d.KSocialKskillsKdevelopmentK-KCORRECTKANSWERK-D
WhichKareaKofKtheKbrainKhasKbeenKimplicatedKtoKmodulateKpainKandKcanKhelpKexplainKhowKtranscr
anialKmagneticKstimulationKcanKhelpKdecreaseKpain?
a.KPrefrontalKcortex
b.KInsulaKcortex
c.KDorsolateralKprefrontalKcortex
d.KAnteriorKcingulateKcortexK-KCORRECTKANSWERK-A
WhichKofKtheKfollowingKantidepressantsKisKassociatedKwithKdose-
relatedKcardiovascularKadverseKeffectsKwhichKrequireKadherenceKtoKmaximumKrecommendedKdosi
ng,KunlessKhigherKdosesKareKdeemedKappropriateKdespiteKrisks?
a.KCitalopramK(Celexa)
, b.KVenlafaxineK(Effexor)
c.KMirtazapineK(Remeron)
d.KSertralineK(Zoloft)K-KCORRECTKANSWERK-A
WhichKofKtheKfollowingKfindingsKwouldKraiseKconcernKinKanKannualKsportsKexamKforKaK15-year-
oldKgirl?
a.KScarKtissueKfromKhymenalKtearKatK11Ko'clockK(reportedKbikingKinjury)
b.KBloodKpressureK86/56
c.KHeightK67Kinches,KweightK102Kpounds
d.KPulseK60,KrespirationsK26K-KCORRECTKANSWERK-C
AKweekKafterKraisingKtheKdoseKofKrisperidoneK(Risperdal),KaKpatientKtreatedKforKschizophreniaKpre
sentsKtoKtheKclinicKwithKreportsKofKanKacuteKchangeKinKmentalKstatus,Kfever,KandKrigidity.KAsKtheKtr
eatingKPMHNP,KyouKknowKtheseKsymptomsKareKconsistentKwithKwhichKofKtheKfollowing?
a.KNeurolepticKmalignantKsyndromeK(NMS)
b.KAnticholinergicKwithdrawalKsyndrome
c.KExtrapyramidalKsideKeffects
d.KSerotoninKsyndromeK-KCORRECTKANSWERK-A
WhichKofKtheKfollowingKstatementsKregardingKdisulfiramK(AntabuseKisKcorrect?
a.KDisulfiramKshouldKnotKbeKtakenKforKatKleastK6KhoursKafterKdrinkingKalcohol.
b.KAvoidKanythingKcontainingKalcoholK(i.e.,Kvinegar,Kmouthwash,Kaftershave,KcoughKmedication)K
whileKusingKdisulfiramKandKforK2KweeksKafterKdiscontinuing.
c.KAKdisulfiram-alcoholKreactionKcanKoccurKupKtoK1KweekKafterKdiscontinuingKdisulfiram.
d.KDisulfiramKcanKlowerKliverKfunctionKtestsKsoKmonitoringKisKnecessary.K-
KCORRECTKANSWERK-B
WhichKmoodKstabilizerKisKmostKassociatedKwithKaKpotentiallyKlife-threateningKrash?
a.KDivalproexK(Depakote)