RATED A+
✔✔The main function of what part of the brain is to relay motor and sensory signals to
the cerebral cortex and regulate sleep, alertness and wakefulness - ✔✔the thalamus
✔✔In what mode does the thalamus function during NREM sleep? - ✔✔Oscillatory
which inhibits transmission of sensory information
✔✔In what mode does the thalamus function during Wake and REM sleep - ✔✔Relay
✔✔What are the key neurotransmitters in the arousal pathway - ✔✔ACh, noradrenaline,
serotonin, dopamine and histamine
✔✔How does caffeine work to block sleep - ✔✔it is an adenosine receptor antagonist
✔✔During periods of wakefulness, where does adenosine build up - ✔✔in the basal
forebrain
✔✔When is prolactin secretion the highest? - ✔✔during sleep
✔✔During what part of sleep do GH levels peak? - ✔✔N3/SWS
✔✔How long after sleep onset does GH release peak? - ✔✔90 minutes
✔✔Effect of sleep on gonadal hormones - ✔✔increase release in puberty
✔✔Changes in sensitivity to chemoreceptors (O2 and CO2) during sleep -
✔✔decreased
✔✔What are the 4 sleep related breathing disorders - ✔✔1. OSA
2. Central sleep apnea
3. Sleep related hypoventilation disorders
4. Sleep related hypoxemia disorders
✔✔. What is treatment emergent central sleep apnea - ✔✔When predominantly
obstructive events are replaced by central apneas or hypopneas on PAP w/o a backup
rate
✔✔What characterizes sleep related hypoventilation disorders - ✔✔An abnormal
increase in arterial PCO2 during sleep
, ✔✔What PCO2 levels define sleep related hypoventilation disorders in adults -
✔✔Increase in PCO2 to >55 for at least 10 minutes or an increase greater than or equal
to 10 above the awake value to a value of 50 or greater for at least 10 minutes
✔✔What PCO2 levels define sleep related hypoventilation disorders in children -
✔✔PCO2 >50 for at least 25% of total sleep time
✔✔Definition of sleep related hypoxemia disorder - ✔✔O2 sat <88 in adults and 90 in
children for at least 5 minutes
✔✔Chronic insomnia disorder - ✔✔sleep onset and/or sleep maintenance complaints
w/associated daytime impairment, at least 3 times per week for 3 mos
✔✔How many Americans have chronic sleep problems - ✔✔About 50 to 70 million
✔✔What sleep disorder are patients with Parkinson's disorder at increased risk of -
✔✔REM behavior disorder
✔✔8 item questionnaire that provides a general measure of a person's daytime
sleepiness or average sleep propensity in daily life - ✔✔Epworth sleepiness scale
✔✔11 item questionnaire used to identify people at increased risk of sleep apnea -
✔✔Berlin questionnaire
✔✔30 item questionnaire used to evaluate quality of life as it pertains to disorders of
excessive sleepiness - ✔✔Functional Outcomes of Sleep Questionnaire (FOSQ)
✔✔Self rated questionnaire that assesses sleep quality and disturbance over a 1-month
period of time - ✔✔Pittsburgh Sleep Quality Index
✔✔Popular 8 item OSA screening questionnaire - ✔✔STOP BANG
✔✔Two sleep questionnaires for children - ✔✔BAERS and Children's sleep habit
questionnaire
✔✔What is a level 2 portal PSG device - ✔✔full unattended PSG device
✔✔What is a level 3 PSG ambulatory device - ✔✔uses a minimum of 4 channels
including respiratory movement, airflow, ECG/heart rate, O2 sat
✔✔What is a level 4 PSG ambulatory device - ✔✔a device that measures fewer than 4
channels including oximetry alone, actigraphy, peripheral arterial tone