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NURS 615 Exam 1 (65 Questions) – Pharmacokinetics, Prescribing, Autonomics – Maryville University

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This document contains 65 expertly answered questions for NURS 615 – Advanced Pharmacology at Maryville University, covering foundational concepts in pharmacology necessary for nurse practitioners and healthcare professionals. Key areas include pharmacokinetics and pharmacodynamics, drug metabolism (with emphasis on cytochrome P450 pathways), first-pass metabolism, protein binding, drug half-life, bioavailability, and drug-receptor interactions. It also explains in detail the phases of drug development, WHO prescribing steps, peak/trough principles, blood-brain and placental barriers, and special considerations in pediatrics, geriatrics, pregnancy, and renal/hepatic impairment. The autonomic pharmacology section covers adrenergic and cholinergic systems, beta-blockers, alpha-blockers, clonidine, anticholinergics, and the clinical application of receptor-specific drugs. This study material is especially valuable for students enrolled in: Family Nurse Practitioner (FNP) Adult-Gerontology NP (AGNP) Doctor of Nursing Practice (DNP) PharmD and PA (Physician Assistant) programs It is also suitable for medical students reviewing pharmacological foundations and prescribing principles. Designed in a clear Q&A format, the guide aids in mastering high-yield concepts for exam prep, clinical application, and certification review. Keywords: NURS 615, pharmacokinetics, pharmacodynamics, CYP450, first-pass effect, prescribing principles, drug metabolism, protein binding, half-life, black box warning, WHO prescribing steps, pediatric pharmacology, geriatric dosing, beta blockers, alpha blockers, clonidine, autonomic pharmacology, cholinergic blockers, St. John's Wort interactions

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Uploaded on
October 5, 2025
Number of pages
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Written in
2025/2026
Type
Exam (elaborations)
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Questions & answers

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Nurs 615 Pharm Exam 1 – Maryville
2025/2026 Exam Questions with 100%
Correct Answers | Latest Update



How does hypoalbuminemia affect the process of prescribing? - 🧠

ANSWER ✔✔Low albumin = more free drug (bc the drug can't bind to

albumin aka protein) = increased adverse effects


What is a Black Box Warning: - 🧠 ANSWER ✔✔is considered a

contraindication to administer that drug.


What is the drugs half-life? - 🧠 ANSWER ✔✔Half-life specifically means the

amount of time it takes for an administered drug to be halfway cleared from

the system.


Peak of action: - 🧠 ANSWER ✔✔the time between drug administration and

maximum concentration of drug in the blood stream. Best therapeutic

effect.

,Duration of action: - 🧠 ANSWER ✔✔the time between onset of action and

metabolism of drug below the minimum needed for an effect. The length of

time you have the drug in your system.

According to the WHO what is the first step in the prescribing process? - 🧠

ANSWER ✔✔The first step is to define the patient's problem


The second step is to - 🧠 ANSWER ✔✔specify the therapeutic objective


The third step is to - 🧠 ANSWER ✔✔choose which drug or treatment is

needed.


Step 4 of the WHO approach: - 🧠 ANSWER ✔✔Start the treatment


Step 5 of the WHO approach: - 🧠 ANSWER ✔✔Educate the patient


Step 6 of the WHO approach: - 🧠 ANSWER ✔✔Monitor the treatment


Phase 1 of drug development: - 🧠 ANSWER ✔✔The drug is tested on

healthy volunteers


Phase 2 of drug development: - 🧠 ANSWER ✔✔trials with people who have

the disease for which the drug is thought to be effective

,Phase 3 of drug development: - 🧠 ANSWER ✔✔Large numbers of patients

in medical research centers receive the drug in phase 3. This larger

sampling provides information about infrequent or rare adverse effects. The

FFA will approve a new drug application if phase 3 studies are satisfactory.


Phase 4 of drug development: - 🧠 ANSWER ✔✔This phase is voluntary

and involves postmarket surveillance of the drug's therapeutic effects at the

completion of phase 3. The pharmaceutical company receives reports from

doctors and other health care professionals about the therapeutic results

and adverse effects of the drug. Some medications, for example, have

been found to be toxic and have been removed from the market after their

initial release.


Explain first pass metabolism - 🧠 ANSWER ✔✔much of the drug is lost in

the absorption process. The liver metabolizes many drugs, thus reduces

the bioavailabilty of the drug.


What is the fasted route of absorption: - 🧠 ANSWER ✔✔The fastest route

of absorption is inhalation, and not as mistakenly considered the IV

administration.




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, Why does the GI tract take longer to absorb? - 🧠 ANSWER ✔✔The GI tract

is lined with epithelial cells; drugs must permeate through these cells in

order to be absorbed into the circulatory system.

What is One particular cellular barrier that may prevent absorption of a

given drug? - 🧠 ANSWER ✔✔the cell membrane. Cell membranes are

essentially lipid bilayers which form a semipermeable membrane. Pure lipid

bilayers are generally permeable only to small and uncharged solutes,

hence whether or not a molecule is ionized will affect its absorption, since

ionic molecules are charged.


What is solubility? - 🧠 ANSWER ✔✔Solubility favors charged species,

permeability favors neutral species. Some molecules have special

exchange proteins and channels to facilitate movement from the lumen into

the circulation.

Why does absorption occur at a slower rate for oral, IM, SQ routes? - 🧠

ANSWER ✔✔Absorption occurs at a slower rate because the complex

membrane systems of GI mucosal layers, muscle, and skin delay drug

passage.

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