BIO 338 IUPUI IMMUNOLOGY LECTURE
FINAL EXAM (4) 2025 QUESTIONS AND
ANSWERS
What does HIV have on Surface - ANS Gp120 and Gp41
What things does HIV NEED to attach to to infiltrate cell - ANS CD4+ and (CXCR4 If attaching
to T cell) OR (CCr5 if attaching to Macrophage)
Brutens XLA - ANS no Antibodies, defect with pre B cell, cannot go past Pre B cell stage. No
MATURE B CELLS,
CANNOT respond to signals
X-linked hyper IgM syndrome (HIS) - ANS no Igg, Iga, Ige But too many IGM
cannot class switch
problem with CD40L
X-linked SCID - ANS Problems with Il2, (activation of T and B cells)
Inhibits B and T cell maturation
Must receive Bone marrow transplant to live
Type 1 BLS - ANS No type 1 MHC
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, only Gamma and Delta Cytotoxic T Cells
What do Tap 1 and 2 do - ANS Move peptide from cytosol to RER to be loaded on MHC 1 and
presented on surface of cell
Type 2 BLS - ANS No MHC class 2
no CD4+ T helper cells
ONLY HAVE IGM
CANNOT CLASS SWITCH
NEED BONE MARROW TRANSPLANT TO LIVE
Graves disease - ANS hyperthyroidism,
too much T3 and T4
Hashimoto's disease - ANS hypothyroidism; antibody made that acts as an antagonist to TSH
receptor (Ab-TSH); therefore, decrease in T3 and T4; decrease in negative feedback; increase in
TRH and increase in TSH
ISCOM - ANS immune stimulating complex
Very expensive vaccine,
allows for cell mediated response to antigen
creates memory
active immunity - ANS A form of acquired immunity in which the body produces its own
antibodies against disease-causing antigens
2 Copyright ©2025 THESTAR ALL RIGHTS RESERVED
FINAL EXAM (4) 2025 QUESTIONS AND
ANSWERS
What does HIV have on Surface - ANS Gp120 and Gp41
What things does HIV NEED to attach to to infiltrate cell - ANS CD4+ and (CXCR4 If attaching
to T cell) OR (CCr5 if attaching to Macrophage)
Brutens XLA - ANS no Antibodies, defect with pre B cell, cannot go past Pre B cell stage. No
MATURE B CELLS,
CANNOT respond to signals
X-linked hyper IgM syndrome (HIS) - ANS no Igg, Iga, Ige But too many IGM
cannot class switch
problem with CD40L
X-linked SCID - ANS Problems with Il2, (activation of T and B cells)
Inhibits B and T cell maturation
Must receive Bone marrow transplant to live
Type 1 BLS - ANS No type 1 MHC
1 Copyright ©2025 THESTAR ALL RIGHTS RESERVED
, only Gamma and Delta Cytotoxic T Cells
What do Tap 1 and 2 do - ANS Move peptide from cytosol to RER to be loaded on MHC 1 and
presented on surface of cell
Type 2 BLS - ANS No MHC class 2
no CD4+ T helper cells
ONLY HAVE IGM
CANNOT CLASS SWITCH
NEED BONE MARROW TRANSPLANT TO LIVE
Graves disease - ANS hyperthyroidism,
too much T3 and T4
Hashimoto's disease - ANS hypothyroidism; antibody made that acts as an antagonist to TSH
receptor (Ab-TSH); therefore, decrease in T3 and T4; decrease in negative feedback; increase in
TRH and increase in TSH
ISCOM - ANS immune stimulating complex
Very expensive vaccine,
allows for cell mediated response to antigen
creates memory
active immunity - ANS A form of acquired immunity in which the body produces its own
antibodies against disease-causing antigens
2 Copyright ©2025 THESTAR ALL RIGHTS RESERVED
