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MIC 319 Exam 4 Exam 2025 Questions and Answers

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MIC 319 Exam 4 Exam 2025 Questions and Answers Extracellular pathogens can be: - ANS bacteria, viruses, fungi, parasite opsonization = - ANS coating of bacterium with antibody and/or complement What is the point of opsonization? - ANS To make the pathogen more readily ingested by phagocytes complement = - ANS collection of plasma proteins that act in a cascade of reactions to attack extracellular forms of pathogens cellular innate responses = - ANS neutrophil and macrophage phagocytosis Killing of microbes by cellular processes begins when? - ANS when they make contact with cells. This process continues within the phagolysosome. Neutrophils are stored in the __________ - ANS bone marrow What are the 4 stages of extravasation of neutrophils: - ANS 1. Rolling adhesion via LFA and ICAM-1 2. Tight binding Pg. 2 Copyright © 2025 Jasonmcconell. ALL RIGHTS RESERVED. 3. Diapedesis 4. Migration along CXCL8 chemokine gradient Receptor for complement? - ANS CD4 Receptor for LPS? - ANS CD14 Molecular innate response to extracellular bacteria? - ANS complement proteins MAC refers to - ANS complement PF referes to - ANS perforin Who discovered P1 and P2 - ANS Dr. Podack The killer domain of pore forming protein is the _____ domain - ANS MACPF Extracellular batteria are killed by - ANS complement membrane attack complex poly-C9 Virus infected cells are killed by - ANS P1 Intracellular bacteria are killed by - ANS P2 The last event of C9 is _______ - ANS making the hole in the bacteria Size of poly C-9 pore? - ANS 110-120 A

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MIC 319 Exam 4 Exam 2025 Questions and
Answers




Extracellular pathogens can be: - ANS bacteria, viruses, fungi, parasite



opsonization = - ANS coating of bacterium with antibody and/or complement



What is the point of opsonization? - ANS To make the pathogen more readily ingested by
phagocytes



complement = - ANS collection of plasma proteins that act in a cascade of reactions to attack
extracellular forms of pathogens



cellular innate responses = - ANS neutrophil and macrophage phagocytosis



Killing of microbes by cellular processes begins when? - ANS when they make contact with
cells. This process continues within the phagolysosome.



Neutrophils are stored in the __________ - ANS bone marrow



What are the 4 stages of extravasation of neutrophils: - ANS 1. Rolling adhesion via LFA and
ICAM-1
2. Tight binding



Pg. 1 Copyright © 2025 Jasonmcconell. ALL RIGHTS RESERVED.

, 3. Diapedesis
4. Migration along CXCL8 chemokine gradient



Receptor for complement? - ANS CD4



Receptor for LPS? - ANS CD14



Molecular innate response to extracellular bacteria? - ANS complement proteins



MAC refers to - ANS complement



PF referes to - ANS perforin



Who discovered P1 and P2 - ANS Dr. Podack



The killer domain of pore forming protein is the _____ domain - ANS MACPF



Extracellular batteria are killed by - ANS complement membrane attack complex poly-C9



Virus infected cells are killed by - ANS P1



Intracellular bacteria are killed by - ANS P2



The last event of C9 is _______ - ANS making the hole in the bacteria



Size of poly C-9 pore? - ANS 110-120 A



Pg. 2 Copyright © 2025 Jasonmcconell. ALL RIGHTS RESERVED.

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