Test bank for Tietz Fundamentals of Clinical Chemistry
and Molecular Diagnostics,
8th Edition by Nader Rifai, PhD
Chapters 1 - 49
,Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics 8th Edition Test Bank
ZX ZX ZX ZX ZX ZX ZX ZX
Z X
ZX ZX
Table of contents: ZX ZX
I. Principles Of Laboratory Medicine
ZX ZX ZX ZX
Chapter 1. Clinical Chemistry, Molecular Diagnostics, and Laboratory Medicine
ZX ZX ZX ZX ZX ZX ZX ZX
Chapter 2. Selection and Analytical Evaluation of Methods — With Statistical Techniques
ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX
Chapter 3. Clinical Evaluation of Methods
ZX ZX ZX ZX ZX
Chapter 4. Evidence-Based Laboratory Medicine
ZX ZX ZX ZX
Chapter 5. Establishment and Use of Reference Values
ZX ZX ZX ZX ZX ZX ZX
Chapter 6. Specimen Collection, Processing, and Other Preanalytical Variables
ZX ZX ZX ZX ZX ZX ZX ZX
Chapter 7. Quality ManagementZX ZX ZX
II. Analytical Techniques And Instrumentation
ZX ZX ZX ZX
Chapter 8. Principles of Basic Techniques and Laboratory Safety
ZX ZX ZX ZX ZX ZX ZX ZX
Chapter 9. Optical TechniquesZX ZX ZX
Chapter 10. Electrochemistry and Chemical Sensors
ZX ZX ZX ZX ZX
Chapter 11. Electrophoresis ZX ZX
Chapter 12. Chromatography ZX ZX
Chapter 13. Mass SpectrometryZX ZX ZX
Chapter 14. Enzyme and Rate Analyses
ZX ZX ZX ZX ZX
Chapter 15. Immunochemical Techniques
ZX ZX ZX
Chapter 16 Automation ZX ZX
Chapter 17. Point-of-Care Instrumentation
ZX ZX ZX
III. Analytes
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Chapter 18. Amino Acids, Peptides, and Proteins
ZX ZX ZX ZX ZX ZX
Chapter 19. Serum Enzymes ZX ZX ZX
Chapter 20. Tumor Markers and Cancer Genes
ZX ZX ZX ZX ZX ZX
Chapter 21. Kidney Function Tests — Creatinine, GFR, Urea, and Uric Acid
ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX
Chapter 22. Carbohydrates ZX ZX
Chapter 23. Lipids, Lipoproteins, Apolipoproteins, and Other Cardiac Risk Factors
ZX ZX ZX ZX ZX ZX ZX ZX ZX
Chapter 24. Electrolytes and Blood Gases
ZX ZX ZX ZX ZX
Chapter 25. Hormones ZX ZX
Chapter 26. Catecholamines and Serotonin
ZX Z X ZX ZX
Chapter 27. Vitamins, Trace Elements, Nutritional Assessment
ZX Z X ZX ZX ZX ZX
Chapter 28. Hemoglobin, Iron, and Bilirubin
ZX ZX ZX ZX ZX
Chapter 29. Porphyrins and Porphyrias
ZX ZX ZX ZX
Chapter 30. Therapeutic Drugs and Their Management
ZX ZX ZX ZX ZX ZX
Chapter 31. Clinical Toxicology
ZX ZX ZX
Chapter 32. Toxic Metals ZX Z X ZX
IV. Pathophysiology
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Chapter 33. Diabetes ZX ZX
,Chapter 34. Cardiovascular Disease
ZX Z X ZX
Chapter 35. Kidney Disease
ZX ZX ZX
Chapter 36. Physiology and Disorders of Water, Electrolyte, and Acid-Base Metabolism
ZX Z X ZX ZX ZX ZX ZX ZX ZX ZX
Chapter 37. Liver Disease
ZX ZXZX ZX
Chapter 38. Gastrointestinal and Pancreatic Diseases
ZX Z X ZX ZX ZX
Chapter 39. Disorders of Bone and Mineral Metabolism
ZX ZXZX ZX ZX ZX ZX ZX
Chapter 40. Disorders of the Pituitary Gland
ZX ZXZX ZX ZX ZX ZX
Chapter 41. Disorders of the Adrenal Cortex
ZX Z X ZX ZX ZX ZX
Chapter 42. Thyroid Disorders
ZX Z X ZX
Chapter 43. Reproduction-Related Disorders
ZX Z X ZX
Chapter 44. Pregnancy and Prenatal Testing
ZX ZXZX ZX ZX ZX
Chapter 45. Newborn Screening and Inborn Errors of Metabolism
ZX Z X ZX ZX ZX ZX ZX ZX
Chapter 46. Pharmacogenetics
ZX ZX
V. Molecular Diagnostics
Z X ZX
Chapter 47. Principles of Molecular Biology
ZX ZX ZX ZX ZX
Chapter 48. Nucleic Acid Techniques and Applications
ZX ZX ZX ZX ZX ZX
Chapter 49. Genomes and Nucleic Acid Alterations
ZX ZX ZX ZX ZX ZX
, Chapter 01: Clinical Chemistry, Molecular Diagnostics, and Laboratory Medicine TestBank
ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX
MULTIPLE CHOICE ZX
1. An individual working in a clinical chemistry laboratory is married to a sales representative w
ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX
ho works for a company that sells chemistry laboratory supplies. When the laboratory manag
ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX
er requests a list of needed supplies, cost of supplies, and vendors, this individual onlyrecom
ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX X
Z
mends the spouse’s company as the vendor. This is considered to be a(n):
ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX
a. accounting issue. ZX
b. possible conflict of interest. ZX ZX ZX
c. maintenance of confidentiality issue. ZX ZX ZX
d. problem with resource allocation. ZX ZX ZX
ANS: B Z X
Concern has been raised over the interrelationships between practitioners in the medical field
ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX X
Z
and commercial suppliers of drugs, devices, equipment, etc., to the medical profession.
ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX
Similarly, relationships have been scrutinized between clinical laboratorians and manufacturer
ZX ZX ZX ZX ZX ZX ZX ZX ZX
s and providers of diagnostic equipment and supplies. These concerns led the National Institut
ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX
es of Health (NIH) in 1995 to require official institutional review of financial disclosure by resear
ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX
chers and management of situations in which disclosure indicates potentialconflicts of interest.
ZX ZX ZX ZX ZX ZX ZX ZX ZX X
Z ZX ZX
DIF: 1 REF: Page 4-5 ZXZXZX ZX OBJ: 6 | 7 Z X ZX ZX
2. A patient visits her physician stating that her prescribed painkiller is not working to reduce t
ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX
he pain following her recent surgery. A friend of the patient claims that the same painkiller“
ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX X
Z
worked wonders” to reduce her pain after the same surgery. The physician states that the di
ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX
fference in the effect of the drug might be caused by ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX
, which is studied in pharmacogenetics.
ZX ZX ZX ZX ZX
a. epidemiology
b. an inherited disease ZX ZX
c. a conflict of interest ZX ZX ZX
d. a genetic variation in drug-metabolizing enzymes
ZX ZX ZX ZX ZX
ANS: D Z X
Pharmacogenetics is the study of the genetic variation of drug metabolism between ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX X
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individuals.
DIF: 1 REF: Page 3 ZXZXZ X ZX OBJ: 1 Z X
3. John works in a molecular diagnostics laboratory and receives a blood sample that has the n
ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX
ame of a close friend printed on the bar-
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coded label. The genetic test that is ordered on thefriend’s sample would provide diagnostic
ZX ZX ZX ZX ZX ZX ZX ZX ZX X
Z ZX ZX ZX ZX
information about a disorder that has a poor prognosis, and the test is usually performed b
ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX
y John. He asks a fellow employee to analyzethe sample for him and not divulge the results.
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Z ZX ZX ZX ZX ZX ZX ZX ZX ZX
This ethical issue concerns: ZX ZX ZX
a. confidentiality of patient genetic and medical information. ZX ZX ZX ZX ZX ZX
b. a conflict of interest. ZX ZX ZX
c. resource allocation. ZX
d. diagnostic accuracy. ZX
and Molecular Diagnostics,
8th Edition by Nader Rifai, PhD
Chapters 1 - 49
,Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics 8th Edition Test Bank
ZX ZX ZX ZX ZX ZX ZX ZX
Z X
ZX ZX
Table of contents: ZX ZX
I. Principles Of Laboratory Medicine
ZX ZX ZX ZX
Chapter 1. Clinical Chemistry, Molecular Diagnostics, and Laboratory Medicine
ZX ZX ZX ZX ZX ZX ZX ZX
Chapter 2. Selection and Analytical Evaluation of Methods — With Statistical Techniques
ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX
Chapter 3. Clinical Evaluation of Methods
ZX ZX ZX ZX ZX
Chapter 4. Evidence-Based Laboratory Medicine
ZX ZX ZX ZX
Chapter 5. Establishment and Use of Reference Values
ZX ZX ZX ZX ZX ZX ZX
Chapter 6. Specimen Collection, Processing, and Other Preanalytical Variables
ZX ZX ZX ZX ZX ZX ZX ZX
Chapter 7. Quality ManagementZX ZX ZX
II. Analytical Techniques And Instrumentation
ZX ZX ZX ZX
Chapter 8. Principles of Basic Techniques and Laboratory Safety
ZX ZX ZX ZX ZX ZX ZX ZX
Chapter 9. Optical TechniquesZX ZX ZX
Chapter 10. Electrochemistry and Chemical Sensors
ZX ZX ZX ZX ZX
Chapter 11. Electrophoresis ZX ZX
Chapter 12. Chromatography ZX ZX
Chapter 13. Mass SpectrometryZX ZX ZX
Chapter 14. Enzyme and Rate Analyses
ZX ZX ZX ZX ZX
Chapter 15. Immunochemical Techniques
ZX ZX ZX
Chapter 16 Automation ZX ZX
Chapter 17. Point-of-Care Instrumentation
ZX ZX ZX
III. Analytes
Z X
Chapter 18. Amino Acids, Peptides, and Proteins
ZX ZX ZX ZX ZX ZX
Chapter 19. Serum Enzymes ZX ZX ZX
Chapter 20. Tumor Markers and Cancer Genes
ZX ZX ZX ZX ZX ZX
Chapter 21. Kidney Function Tests — Creatinine, GFR, Urea, and Uric Acid
ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX
Chapter 22. Carbohydrates ZX ZX
Chapter 23. Lipids, Lipoproteins, Apolipoproteins, and Other Cardiac Risk Factors
ZX ZX ZX ZX ZX ZX ZX ZX ZX
Chapter 24. Electrolytes and Blood Gases
ZX ZX ZX ZX ZX
Chapter 25. Hormones ZX ZX
Chapter 26. Catecholamines and Serotonin
ZX Z X ZX ZX
Chapter 27. Vitamins, Trace Elements, Nutritional Assessment
ZX Z X ZX ZX ZX ZX
Chapter 28. Hemoglobin, Iron, and Bilirubin
ZX ZX ZX ZX ZX
Chapter 29. Porphyrins and Porphyrias
ZX ZX ZX ZX
Chapter 30. Therapeutic Drugs and Their Management
ZX ZX ZX ZX ZX ZX
Chapter 31. Clinical Toxicology
ZX ZX ZX
Chapter 32. Toxic Metals ZX Z X ZX
IV. Pathophysiology
Z X
Chapter 33. Diabetes ZX ZX
,Chapter 34. Cardiovascular Disease
ZX Z X ZX
Chapter 35. Kidney Disease
ZX ZX ZX
Chapter 36. Physiology and Disorders of Water, Electrolyte, and Acid-Base Metabolism
ZX Z X ZX ZX ZX ZX ZX ZX ZX ZX
Chapter 37. Liver Disease
ZX ZXZX ZX
Chapter 38. Gastrointestinal and Pancreatic Diseases
ZX Z X ZX ZX ZX
Chapter 39. Disorders of Bone and Mineral Metabolism
ZX ZXZX ZX ZX ZX ZX ZX
Chapter 40. Disorders of the Pituitary Gland
ZX ZXZX ZX ZX ZX ZX
Chapter 41. Disorders of the Adrenal Cortex
ZX Z X ZX ZX ZX ZX
Chapter 42. Thyroid Disorders
ZX Z X ZX
Chapter 43. Reproduction-Related Disorders
ZX Z X ZX
Chapter 44. Pregnancy and Prenatal Testing
ZX ZXZX ZX ZX ZX
Chapter 45. Newborn Screening and Inborn Errors of Metabolism
ZX Z X ZX ZX ZX ZX ZX ZX
Chapter 46. Pharmacogenetics
ZX ZX
V. Molecular Diagnostics
Z X ZX
Chapter 47. Principles of Molecular Biology
ZX ZX ZX ZX ZX
Chapter 48. Nucleic Acid Techniques and Applications
ZX ZX ZX ZX ZX ZX
Chapter 49. Genomes and Nucleic Acid Alterations
ZX ZX ZX ZX ZX ZX
, Chapter 01: Clinical Chemistry, Molecular Diagnostics, and Laboratory Medicine TestBank
ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX
MULTIPLE CHOICE ZX
1. An individual working in a clinical chemistry laboratory is married to a sales representative w
ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX
ho works for a company that sells chemistry laboratory supplies. When the laboratory manag
ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX
er requests a list of needed supplies, cost of supplies, and vendors, this individual onlyrecom
ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX X
Z
mends the spouse’s company as the vendor. This is considered to be a(n):
ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX
a. accounting issue. ZX
b. possible conflict of interest. ZX ZX ZX
c. maintenance of confidentiality issue. ZX ZX ZX
d. problem with resource allocation. ZX ZX ZX
ANS: B Z X
Concern has been raised over the interrelationships between practitioners in the medical field
ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX X
Z
and commercial suppliers of drugs, devices, equipment, etc., to the medical profession.
ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX
Similarly, relationships have been scrutinized between clinical laboratorians and manufacturer
ZX ZX ZX ZX ZX ZX ZX ZX ZX
s and providers of diagnostic equipment and supplies. These concerns led the National Institut
ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX
es of Health (NIH) in 1995 to require official institutional review of financial disclosure by resear
ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX
chers and management of situations in which disclosure indicates potentialconflicts of interest.
ZX ZX ZX ZX ZX ZX ZX ZX ZX X
Z ZX ZX
DIF: 1 REF: Page 4-5 ZXZXZX ZX OBJ: 6 | 7 Z X ZX ZX
2. A patient visits her physician stating that her prescribed painkiller is not working to reduce t
ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX
he pain following her recent surgery. A friend of the patient claims that the same painkiller“
ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX X
Z
worked wonders” to reduce her pain after the same surgery. The physician states that the di
ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX
fference in the effect of the drug might be caused by ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX
, which is studied in pharmacogenetics.
ZX ZX ZX ZX ZX
a. epidemiology
b. an inherited disease ZX ZX
c. a conflict of interest ZX ZX ZX
d. a genetic variation in drug-metabolizing enzymes
ZX ZX ZX ZX ZX
ANS: D Z X
Pharmacogenetics is the study of the genetic variation of drug metabolism between ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX X
Z
individuals.
DIF: 1 REF: Page 3 ZXZXZ X ZX OBJ: 1 Z X
3. John works in a molecular diagnostics laboratory and receives a blood sample that has the n
ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX
ame of a close friend printed on the bar-
ZX ZX ZX ZX ZX ZX ZX ZX
coded label. The genetic test that is ordered on thefriend’s sample would provide diagnostic
ZX ZX ZX ZX ZX ZX ZX ZX ZX X
Z ZX ZX ZX ZX
information about a disorder that has a poor prognosis, and the test is usually performed b
ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX ZX
y John. He asks a fellow employee to analyzethe sample for him and not divulge the results.
ZX ZX ZX ZX ZX ZX ZX ZX X
Z ZX ZX ZX ZX ZX ZX ZX ZX ZX
This ethical issue concerns: ZX ZX ZX
a. confidentiality of patient genetic and medical information. ZX ZX ZX ZX ZX ZX
b. a conflict of interest. ZX ZX ZX
c. resource allocation. ZX
d. diagnostic accuracy. ZX
