Coagulation Cascade with solved questions
what starts the coagulation cascade? Correct Answer-tissue factor
what is the coagulation cascade? Correct Answer-in body amplification
system relying on a series of enzymatic reactions in which proenzymes
(aka zymogens) are cleaved and converted to activated enzymes
What are zymogens/proenzymes? Correct Answer-inactive form of the
active enzyme
-need a part to be cleaved by searing protease in order for them to
become active
whats the endpoint of the coagulation cascade? Correct Answer-fibrin
mesh
which factors are NOT enzymatic? (the rest are) Correct Answer-
fibrinogen, factor 5, and HMWK
what is the traditional model based on? how is it unhelpful and helpful?
Correct Answer-what happens in lab: split into intrinsic, extrinsic and
common pathways
can't appreciate amplification (at same time and exponentially)
helpful in knowing what to test for
in what way in the coagulation cascade not one to one? Correct Answer-
one factor can cleave many molecules
, proenzymes can be activated and become searing proteases
What's the extrinsic pathway? Correct Answer-anything that relies on
tissue factor for activation
TF, factor 7, factor 10
What's the intrinsic pathway? Correct Answer-NOT reliant on TF for
activation
factors 8, 9, 10, 11, 12
what's the common pathway? Correct Answer-factor 10, thrombin, and
fibrin
what is the contemporary model like? Correct Answer-multicomponent
complexes that assemble on anionic phospholipid surface (require Ca+)
divided into enzyme, cofactor and substrate
what complexes are in the contemporary model and what do they
include? Correct Answer-order=enzyme,cofactor,substrate
extrinsic X-ase: VIIa, TF, X
intrinsic X-ase: IXa, VIIIa, X
prothombinase: Xa, Va, prothrombin
protein C complex: thrombin, thrombomodulin, protein C
what starts the coagulation cascade? Correct Answer-tissue factor
what is the coagulation cascade? Correct Answer-in body amplification
system relying on a series of enzymatic reactions in which proenzymes
(aka zymogens) are cleaved and converted to activated enzymes
What are zymogens/proenzymes? Correct Answer-inactive form of the
active enzyme
-need a part to be cleaved by searing protease in order for them to
become active
whats the endpoint of the coagulation cascade? Correct Answer-fibrin
mesh
which factors are NOT enzymatic? (the rest are) Correct Answer-
fibrinogen, factor 5, and HMWK
what is the traditional model based on? how is it unhelpful and helpful?
Correct Answer-what happens in lab: split into intrinsic, extrinsic and
common pathways
can't appreciate amplification (at same time and exponentially)
helpful in knowing what to test for
in what way in the coagulation cascade not one to one? Correct Answer-
one factor can cleave many molecules
, proenzymes can be activated and become searing proteases
What's the extrinsic pathway? Correct Answer-anything that relies on
tissue factor for activation
TF, factor 7, factor 10
What's the intrinsic pathway? Correct Answer-NOT reliant on TF for
activation
factors 8, 9, 10, 11, 12
what's the common pathway? Correct Answer-factor 10, thrombin, and
fibrin
what is the contemporary model like? Correct Answer-multicomponent
complexes that assemble on anionic phospholipid surface (require Ca+)
divided into enzyme, cofactor and substrate
what complexes are in the contemporary model and what do they
include? Correct Answer-order=enzyme,cofactor,substrate
extrinsic X-ase: VIIa, TF, X
intrinsic X-ase: IXa, VIIIa, X
prothombinase: Xa, Va, prothrombin
protein C complex: thrombin, thrombomodulin, protein C
