Coagulation Cascade Questions with correct answer2.

Coagulation Cascade Questions with correct answers

Where do the reactions of the coagulation cascade occur? What ion do
they require? Correct Answer-phospholipid surface (like platelets)


require Ca ions


What does thrombin do? Correct Answer-converts soluble plasma
fibrinogen into insoluble fibrin monomers which polymerize into an
insolube gel (which holds platelets together)


What factor is involved in the extrinsic pathway? Correct Answer-Factor
VII


What factors are involved in the intrinsic pathway? Correct Answer-
Factors XII, XI, IX, VIII


What factors are involved in the final common pathway? Correct Answer-
Factors X, V
prothrombin
fibrinogen


What initiates the extrinsic pathway? How? Correct Answer-Tissue Factor
(thromboplastin)

, forms a complex with factor VIIa


What does the Tissue Factor:VIIa complex do? Correct Answer-activates
factor X in common pathway (Ca needed) --> Xa


What organs are high concentrations of Tissue Factor found in? Correct
Answer-skin
brain
lung and placenta
monocytes in adventia of large blood vessels


Is Tissue Factor normally in contact with blood? Correct Answer-no
clotting is initiated when blood is exposed to tissue factor (like when
injury occurs)


How is the intrinsic pathway activated? Correct Answer-by exposure of
Factor XII (Hageman factor) to
1) subendothelial collagen or
2) HMWK (high molecular weight kininogen)


to produce Factor XIIa


What does factor XIIa do? Correct Answer-1) activates factor XI --> XIa
2) activates plasminogen --> plasmin