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NR 603 Week 7 Quiz Exam | Primary
Care of Childbearing & Childrearing
Family | Latest 2026/2027 | Verified
Q&A | Grade A Guarantee
Exam Structure:
Subject: Advanced Pathophysiology & Rheumatology (NR 603)
Source: NR 603 Week 7 Quiz Exam
Format: Question & Answer, Fill-in-the-Blank, Descriptive
1. Rheumatoid factor is an autoantibody directed against what? What
are its clinical significance and limitations?
Answer: Autoantibody for Fc portion of IgG. Positive in 85% of patients, but
false positive in 5%, and 10-20% healthy over age of 65.
NOT a screening test, NOT specific for RA. Used to confirm diagnosis
with suggestive clinical presentation.
High titers tend to have more severe and progressive disease.
Correlates with extraskeletal manifestations (nodules). RA vasculitis
patients have high titers.
Fluctuation of titers in individual patients does not correlate with
disease activity (might go up or down).
Rationale:
1. Rheumatoid Factor (RF) is an IgM autoantibody that targets the Fc
portion of IgG, forming immune complexes.
2. While found in 85% of RA patients, its lack of specificity (positive in
other diseases and healthy elderly) means it is not a standalone
diagnostic or screening tool.
3. It is most useful as a confirmatory test when clinical suspicion for
RA is already high.
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4. High titers are prognostic, indicating a greater likelihood of severe,
erosive disease and extra-articular features like rheumatoid nodules
and vasculitis.
2. What does a CBC in Rheumatoid Arthritis typically show?
Answer:
Anemia of chronic disease (low iron, low TIBC, high ferritin)
Thrombocytosis (acute phase reactant correlating with disease
activity)
Eosinophilia (in severe systemic disease)
Leukopenia
Felty's syndrome: RA, splenomegaly, leukopenia (usually long-
standing RA)
Pseudofelty's: RA, splenomegaly, normal WBC with large granular
lymphocytosis but neutropenia
Rationale:
1. The chronic inflammation in RA leads to anemia of chronic disease,
characterized by functional iron deficiency.
2. Thrombocytosis is an acute-phase response, and its level often
parallels disease activity.
3. Eosinophilia can signal severe, systemic RA.
4. Leukopenia, especially in the context of splenomegaly (Felty's
syndrome), indicates advanced, long-standing disease and immune
dysregulation.
3. What will synovial fluid analysis in RA show?
Answer: Inflammation, WBC >2000 (often 10,000).
Rationale:
1. RA is an inflammatory arthritis. Synovial fluid reflects this with an
elevated white blood cell count, typically in the inflammatory
range (>2,000 cells/µL), often between 5,000–50,000 cells/µL.
2. The fluid is usually turbid with decreased viscosity, consistent with
an active inflammatory process within the joint.
4. What does radiological evaluation of RA show over time?
Answer:
NR 603 Week 7 Quiz Exam | Primary
Care of Childbearing & Childrearing
Family | Latest 2026/2027 | Verified
Q&A | Grade A Guarantee
Exam Structure:
Subject: Advanced Pathophysiology & Rheumatology (NR 603)
Source: NR 603 Week 7 Quiz Exam
Format: Question & Answer, Fill-in-the-Blank, Descriptive
1. Rheumatoid factor is an autoantibody directed against what? What
are its clinical significance and limitations?
Answer: Autoantibody for Fc portion of IgG. Positive in 85% of patients, but
false positive in 5%, and 10-20% healthy over age of 65.
NOT a screening test, NOT specific for RA. Used to confirm diagnosis
with suggestive clinical presentation.
High titers tend to have more severe and progressive disease.
Correlates with extraskeletal manifestations (nodules). RA vasculitis
patients have high titers.
Fluctuation of titers in individual patients does not correlate with
disease activity (might go up or down).
Rationale:
1. Rheumatoid Factor (RF) is an IgM autoantibody that targets the Fc
portion of IgG, forming immune complexes.
2. While found in 85% of RA patients, its lack of specificity (positive in
other diseases and healthy elderly) means it is not a standalone
diagnostic or screening tool.
3. It is most useful as a confirmatory test when clinical suspicion for
RA is already high.
, 2|Page
4. High titers are prognostic, indicating a greater likelihood of severe,
erosive disease and extra-articular features like rheumatoid nodules
and vasculitis.
2. What does a CBC in Rheumatoid Arthritis typically show?
Answer:
Anemia of chronic disease (low iron, low TIBC, high ferritin)
Thrombocytosis (acute phase reactant correlating with disease
activity)
Eosinophilia (in severe systemic disease)
Leukopenia
Felty's syndrome: RA, splenomegaly, leukopenia (usually long-
standing RA)
Pseudofelty's: RA, splenomegaly, normal WBC with large granular
lymphocytosis but neutropenia
Rationale:
1. The chronic inflammation in RA leads to anemia of chronic disease,
characterized by functional iron deficiency.
2. Thrombocytosis is an acute-phase response, and its level often
parallels disease activity.
3. Eosinophilia can signal severe, systemic RA.
4. Leukopenia, especially in the context of splenomegaly (Felty's
syndrome), indicates advanced, long-standing disease and immune
dysregulation.
3. What will synovial fluid analysis in RA show?
Answer: Inflammation, WBC >2000 (often 10,000).
Rationale:
1. RA is an inflammatory arthritis. Synovial fluid reflects this with an
elevated white blood cell count, typically in the inflammatory
range (>2,000 cells/µL), often between 5,000–50,000 cells/µL.
2. The fluid is usually turbid with decreased viscosity, consistent with
an active inflammatory process within the joint.
4. What does radiological evaluation of RA show over time?
Answer:
