Chronic productive cough (3 consecutive months for at least 2 successive years)
-release of inflammatory mediators( histamine, prostaglandins, leukotrienes,
interleukins)
-smooth muscle constriction, hypertrophy
- Airflow obstruction ( SOB, wheezing, cyanosis)
- Peripheral edema
- alveolar hyperinflation
- CO2 retention
- Irreversible
Caused by:
-Long-term exposure to environmental irritants
- Repeated episodes of acute bronchitis
- Factor(s) affecting gestational or childhood lung development - the most common
being pre-term birth and/or RSV infection in early infancy
nephron anatomy - CORRECT ANSWERS -
kidney anatomy - CORRECT ANSWERS -
- CORRECT ANSWERS -
Nephron - CORRECT ANSWERS -Multicellular structure
- Bowman's capsule
- Tubule system (PCT, Loop of henle, DCT, and collecting duct)
- Glomerular & Peritubular capillaries surround each nephron
-Cannot regenerate
- GFR decreased by 1 ml/min/year after 30
- Filtration
-Reabsorption
- Secretion
- Excretion
Glomerular filtration - CORRECT ANSWERS -- Blood pressure forces water and
dissolved plasma components ( Glucose, ions, amino acids, urea, and creatinine)
through glomerulus & Bowman's capsule into the renal tubule system
Tubular reabsorption - CORRECT ANSWERS -Selective return of water and solutes (
glucose, ions, amino acids, urea) FROM the filtrate of the nephron tubule system INTO
the bloodstream of the peritubular capillaries
, -65% of salt, water and most organic substances are reabsorbed in the PCT
- Remainder of water and ions are reabsorbed throughout the tubule system; ADH &
Aldosterone influence amounts
Tubular Secretion - CORRECT ANSWERS -- Movement of material (Urea, NH3, H, K,
some Rx, Misc chem) FROM the bloodstream of the peritubular capillaries INTO the
filtrate of the nephron tubule system
proximal tubule - CORRECT ANSWERS -Reabsorption
-Na, Glucose, K, Amino acids, Hco3, Po4, Urea, H2o (ADH not required)
Secretion
-H, Foreign substances
Isotonic
Loop of Henle - CORRECT ANSWERS -Desc loop
-Water reabsorption, NA diffuses in
Asc loop
-Na reabsorbed (active transport), water stays in
Urea secretion in thin segment
Isotonic, Hyper and hypotonic
Distal tubule - CORRECT ANSWERS -Reabsorption
-Na, H2o (ADH required), Hco3
Secretion
-K, Urea, H, Nh3, some drugs
Hypotonic
Collecting duct - CORRECT ANSWERS -Reabsorption of H2o (ADH required)
reabsorb or secret Na, K, H, Nh3
Urea reabsorbed in medulla
Final concentration
Urinary Excretion - CORRECT ANSWERS --Final elimination of wastes, excess water
and ions
-Creat, Urea, NH3, H