Immuno Exam 4 (Wiegel) PCB 3233
bone marrow; thymus - correct answer ✔✔T-cells originate from the _______________ and maturate in
the _______________.
VJ - correct answer ✔✔What gene segments are rearranged for the alpha chain?
VDJ - correct answer ✔✔What gene segments are rearranged for the beta chain?
yes - correct answer ✔✔Are the RAG genes used in rearrangement?
TCR-beta & pre-T alpha - correct answer ✔✔What makes up a pre-TCR?
IL7 - correct answer ✔✔A cytokine secreted by the thymic stromal cells; binds on CD34 progenitor cells;
during thymocytic commitment.
Notch-1 - correct answer ✔✔Thymocytic cell surface receptor; interacts with transmembrane ligands on
thymic epithelial cells.; lead T-cells to differentiation.
DiGeorge - correct answer ✔✔The ______________________ syndrome is caused by a failure of
development of the thymus.
22 - correct answer ✔✔The failure to develop the thymus is due to a deletion on chromosome
_________.
negative - correct answer ✔✔Double-_______________ thymocytes are called so because they DONT
have both CD4 & CD8.
recombination - correct answer ✔✔RAG 1 & 2 are also working on somatic _______________________
of the T-cell genes.
, 12/23 - correct answer ✔✔The _______________ rule states that
first - correct answer ✔✔Positive selection occurs _____________, followed by negative selection.
both - correct answer ✔✔Positive and negative selection _______________ occur in the thymus.
outlive - correct answer ✔✔T-cells_______________ B-cells.
12; 1; 2 - correct answer ✔✔If you are heterozygous for the HLA genes, you have a total of _________
molecules; 6 from class ______ and 6 from class ______.
120000 - correct answer ✔✔Heterozygotic HLA genes can lead to around _______________ peptides.
before - correct answer ✔✔γ:δ T-Cell: functional γ:δ receptor is made ____________ β chain
Pre T Cell - correct answer ✔✔____________________ Receptor: β chain is made before γ:δ receptor
negative thymocytes - correct answer ✔✔α:β T-Cell: makes α:β receptor before γ:δ receptor;
_________________________ first and then positive.
deletion - correct answer ✔✔_______________ of δ-chain genes happens after α-chain genes are
rearranged.
not - correct answer ✔✔Deletion of δ-chain genesis ________ relative to whether or not rearrangement
was productive.
one - correct answer ✔✔α:β Lineage: ______ productive gene arrangement
two - correct answer ✔✔γ:δ Lineage: _______ productive gene arrangements
bone marrow; thymus - correct answer ✔✔T-cells originate from the _______________ and maturate in
the _______________.
VJ - correct answer ✔✔What gene segments are rearranged for the alpha chain?
VDJ - correct answer ✔✔What gene segments are rearranged for the beta chain?
yes - correct answer ✔✔Are the RAG genes used in rearrangement?
TCR-beta & pre-T alpha - correct answer ✔✔What makes up a pre-TCR?
IL7 - correct answer ✔✔A cytokine secreted by the thymic stromal cells; binds on CD34 progenitor cells;
during thymocytic commitment.
Notch-1 - correct answer ✔✔Thymocytic cell surface receptor; interacts with transmembrane ligands on
thymic epithelial cells.; lead T-cells to differentiation.
DiGeorge - correct answer ✔✔The ______________________ syndrome is caused by a failure of
development of the thymus.
22 - correct answer ✔✔The failure to develop the thymus is due to a deletion on chromosome
_________.
negative - correct answer ✔✔Double-_______________ thymocytes are called so because they DONT
have both CD4 & CD8.
recombination - correct answer ✔✔RAG 1 & 2 are also working on somatic _______________________
of the T-cell genes.
, 12/23 - correct answer ✔✔The _______________ rule states that
first - correct answer ✔✔Positive selection occurs _____________, followed by negative selection.
both - correct answer ✔✔Positive and negative selection _______________ occur in the thymus.
outlive - correct answer ✔✔T-cells_______________ B-cells.
12; 1; 2 - correct answer ✔✔If you are heterozygous for the HLA genes, you have a total of _________
molecules; 6 from class ______ and 6 from class ______.
120000 - correct answer ✔✔Heterozygotic HLA genes can lead to around _______________ peptides.
before - correct answer ✔✔γ:δ T-Cell: functional γ:δ receptor is made ____________ β chain
Pre T Cell - correct answer ✔✔____________________ Receptor: β chain is made before γ:δ receptor
negative thymocytes - correct answer ✔✔α:β T-Cell: makes α:β receptor before γ:δ receptor;
_________________________ first and then positive.
deletion - correct answer ✔✔_______________ of δ-chain genes happens after α-chain genes are
rearranged.
not - correct answer ✔✔Deletion of δ-chain genesis ________ relative to whether or not rearrangement
was productive.
one - correct answer ✔✔α:β Lineage: ______ productive gene arrangement
two - correct answer ✔✔γ:δ Lineage: _______ productive gene arrangements
