IMMUNOLOGY EXAM 5 WEIGEL
What different cells can become plasma cells. - correct answer ✔✔activated B cells ; isotype switched,
somatically hypermutated centrocytes ; memory B cells
What are the components of the B cell co-receptor - correct answer ✔✔CR2 ; CD19 ; CD81 = TAPA-1
What does CR1 do for the co-receptor?
Helps ________ to cleave __________ ; Binding of _____ (On the B-cell) to ______ (on the pathogen)
makes it susceptible to cleavage to ______. _______ (part of the B-cell co-receptor) can then bind to the
______. The signal is sent through ________. - correct answer ✔✔factor I ; C3b>C3d ; CR1 ; C4b ; C4d ;
CR2 ; C3d ; CD19
CR1 binds to ________ - correct answer ✔✔C4B
TI stands for _____________ ; TD stands for _______________ - correct answer ✔✔Thymus
independent ; Thymus dependent
Describe B cell activation, CD40 ligand, CD40, NFkB, ICAM-1 and IL-4 secretion by T cells.
For B cell activation the ______ must meet its appropriate antigen, and the co- receptor, CD40 must
meet _________ on a T cell. The CD40:CD40L interaction causes the B cell to activate transcription factor
_______, NFkB regulates ___________ and once NFkB is activated ________ is up regulated and
expressed on the B cell surface. ICAM-1 on the B cell surface then binds to ________ on the T cell
surface. Once these receptors have been connected the T cell begins to secrete _______ onto the B cell
surface. IL-4 is very important cytokine that drives __________________. - correct answer ✔✔BCR ;
CD40L ; NFkB ; ICAM-1 ; ICAM-1 ; LFA-1 ; IL-4 ; B cell proliferation
Define: follicular dendritic cells (dark zone/light zone)
Characteristic ________________ cells of follicles in ________________ lymphoid tissues. They have
_________ branching processes that make intimate contact with _____________ and have _____ and
, _____________ receptors that hold antigen:antibody:complement complexes on their surfaces for long
periods. These cells are crucial in selecting _________________________ during antibody responses. -
correct answer ✔✔nonlymphoid ; secondary ; long ; B cells ; Fc ; complement ; antigen-binding B cells
Dark Zone: Area in the _____________________ containing closely packed ____________________
(____%) - correct answer ✔✔germinal center ; centroblasts ; 80
Light Zone: Area in the _________________ containing _______________________ that will interact -
correct answer ✔✔germinal center ; non-dividing centrocytes
How do antibodies function? Do they destroy the pathogen directly or do they tag and cover up things?
Antibodies ______ destroy the pathogen directly. They do 3 things: ____________, ____________, and
____________ - correct answer ✔✔don't ; neutralization ; opsonization ; complement activation
Neutralization: - correct answer ✔✔It covers up all the sites that the Ag would use to bind with cells
Opsonization: - correct answer ✔✔Tagging pathogens for phagocytosis
Complement activation: - correct answer ✔✔Complement Activation of the classical pathway
Antigen binding (does the B cell take up the antigen, what is this called)
Binding of antigen sends a signal to the B cells' _________ to change _______________. Yes the B cell
takes up the ________ by internalizing Ag by ___________________________ which processes and
presents it to _______________ - correct answer ✔✔nucleus ; gene expression ; antigen ; receptor
mediated endocytosis ; helper T-cells
What are the cognate interactions?
Cognate interactions are interactions between a ___________ and a ________ that recognize the same
antigen. When antigen-activated B-cells present antigen to helper T-cell. - correct answer ✔✔B cell ; T
cell
What different cells can become plasma cells. - correct answer ✔✔activated B cells ; isotype switched,
somatically hypermutated centrocytes ; memory B cells
What are the components of the B cell co-receptor - correct answer ✔✔CR2 ; CD19 ; CD81 = TAPA-1
What does CR1 do for the co-receptor?
Helps ________ to cleave __________ ; Binding of _____ (On the B-cell) to ______ (on the pathogen)
makes it susceptible to cleavage to ______. _______ (part of the B-cell co-receptor) can then bind to the
______. The signal is sent through ________. - correct answer ✔✔factor I ; C3b>C3d ; CR1 ; C4b ; C4d ;
CR2 ; C3d ; CD19
CR1 binds to ________ - correct answer ✔✔C4B
TI stands for _____________ ; TD stands for _______________ - correct answer ✔✔Thymus
independent ; Thymus dependent
Describe B cell activation, CD40 ligand, CD40, NFkB, ICAM-1 and IL-4 secretion by T cells.
For B cell activation the ______ must meet its appropriate antigen, and the co- receptor, CD40 must
meet _________ on a T cell. The CD40:CD40L interaction causes the B cell to activate transcription factor
_______, NFkB regulates ___________ and once NFkB is activated ________ is up regulated and
expressed on the B cell surface. ICAM-1 on the B cell surface then binds to ________ on the T cell
surface. Once these receptors have been connected the T cell begins to secrete _______ onto the B cell
surface. IL-4 is very important cytokine that drives __________________. - correct answer ✔✔BCR ;
CD40L ; NFkB ; ICAM-1 ; ICAM-1 ; LFA-1 ; IL-4 ; B cell proliferation
Define: follicular dendritic cells (dark zone/light zone)
Characteristic ________________ cells of follicles in ________________ lymphoid tissues. They have
_________ branching processes that make intimate contact with _____________ and have _____ and
, _____________ receptors that hold antigen:antibody:complement complexes on their surfaces for long
periods. These cells are crucial in selecting _________________________ during antibody responses. -
correct answer ✔✔nonlymphoid ; secondary ; long ; B cells ; Fc ; complement ; antigen-binding B cells
Dark Zone: Area in the _____________________ containing closely packed ____________________
(____%) - correct answer ✔✔germinal center ; centroblasts ; 80
Light Zone: Area in the _________________ containing _______________________ that will interact -
correct answer ✔✔germinal center ; non-dividing centrocytes
How do antibodies function? Do they destroy the pathogen directly or do they tag and cover up things?
Antibodies ______ destroy the pathogen directly. They do 3 things: ____________, ____________, and
____________ - correct answer ✔✔don't ; neutralization ; opsonization ; complement activation
Neutralization: - correct answer ✔✔It covers up all the sites that the Ag would use to bind with cells
Opsonization: - correct answer ✔✔Tagging pathogens for phagocytosis
Complement activation: - correct answer ✔✔Complement Activation of the classical pathway
Antigen binding (does the B cell take up the antigen, what is this called)
Binding of antigen sends a signal to the B cells' _________ to change _______________. Yes the B cell
takes up the ________ by internalizing Ag by ___________________________ which processes and
presents it to _______________ - correct answer ✔✔nucleus ; gene expression ; antigen ; receptor
mediated endocytosis ; helper T-cells
What are the cognate interactions?
Cognate interactions are interactions between a ___________ and a ________ that recognize the same
antigen. When antigen-activated B-cells present antigen to helper T-cell. - correct answer ✔✔B cell ; T
cell
