Immunology PCB3233 Exam 1 UCF
4 Human Pathogen Types - correct answer ✔✔viruses
parasites
fungi
bacteria
Extracellular infections accessible to - correct answer ✔✔soluble immune system molecules
Intracellular infections accessible to - correct answer ✔✔insoluble immune system molecules
in nucleus/cytosol = kill host cell
in vesicle = activate infected cell to increase antimicrobial activity
why do parasites infect other organisms - correct answer ✔✔complete life cycle
Compliment - correct answer ✔✔tags pathogens and extracellular molecules for destruction
MAC - correct answer ✔✔Membrane attack complex
C5-C9
Compliment Pathways (in chron. order) - correct answer ✔✔Alternative
Lectin
Classical
Compliment Fixation - correct answer ✔✔C3b contently binds to bacterium w/ thioester bond
Zymogen - correct answer ✔✔soluble proteases that circulate in inactive form
, 1st immune system component to be activated - correct answer ✔✔compliment
1st step in alternative pathway - correct answer ✔✔spontanious hydrolysis and activation of compliment
component C3
C3 Hydrolosis - correct answer ✔✔Where: Alternative pathway
spontaneous at low rate
no cleavage of C3
iC3 is product
Alternative C3 Convertaise - correct answer ✔✔Soluble
iC3Bb
Factor B - correct answer ✔✔binds to C3b
factors - correct answer ✔✔B = binds
D = cleaves
H = makes C3 susceptible to cleavage by I
I = cleaves C3b to iC3b
P = properdin, makes sure C3b not deposited on human cells, protects C3b from H
Opsonin - correct answer ✔✔facilitates phagocytosis
protein bound to pathogen surface
CR1 - correct answer ✔✔Compliment Receptor 1
binds to C3b on microbial surfaces->phagocytosis
protective role on human cells by disrupting C3 convertase
4 Human Pathogen Types - correct answer ✔✔viruses
parasites
fungi
bacteria
Extracellular infections accessible to - correct answer ✔✔soluble immune system molecules
Intracellular infections accessible to - correct answer ✔✔insoluble immune system molecules
in nucleus/cytosol = kill host cell
in vesicle = activate infected cell to increase antimicrobial activity
why do parasites infect other organisms - correct answer ✔✔complete life cycle
Compliment - correct answer ✔✔tags pathogens and extracellular molecules for destruction
MAC - correct answer ✔✔Membrane attack complex
C5-C9
Compliment Pathways (in chron. order) - correct answer ✔✔Alternative
Lectin
Classical
Compliment Fixation - correct answer ✔✔C3b contently binds to bacterium w/ thioester bond
Zymogen - correct answer ✔✔soluble proteases that circulate in inactive form
, 1st immune system component to be activated - correct answer ✔✔compliment
1st step in alternative pathway - correct answer ✔✔spontanious hydrolysis and activation of compliment
component C3
C3 Hydrolosis - correct answer ✔✔Where: Alternative pathway
spontaneous at low rate
no cleavage of C3
iC3 is product
Alternative C3 Convertaise - correct answer ✔✔Soluble
iC3Bb
Factor B - correct answer ✔✔binds to C3b
factors - correct answer ✔✔B = binds
D = cleaves
H = makes C3 susceptible to cleavage by I
I = cleaves C3b to iC3b
P = properdin, makes sure C3b not deposited on human cells, protects C3b from H
Opsonin - correct answer ✔✔facilitates phagocytosis
protein bound to pathogen surface
CR1 - correct answer ✔✔Compliment Receptor 1
binds to C3b on microbial surfaces->phagocytosis
protective role on human cells by disrupting C3 convertase
