NAPLEX antibiotics Actual Exam
Questions With Accurate Solutions
Rated A+!!
MIC - CORRECT ANSWER-lowest drug concentration that prevents visibile microbial
growth in 24 hours
gram (+) bacteria species - CORRECT ANSWER-staph, strep, EC, clostridium, listeria
which antibiotics exhibit time-dependent killing? - CORRECT ANSWER-penicillins,
cephalosporins
how can you increase the killing of a time-dependent antibiotic? - CORRECT ANSWER-
dose more frequently, extend the infusion time
example of concentration-dependent antibiotic? - CORRECT ANSWER-
aminoglycosides (gentamicin, tobramycin, amikacin)
what are the bacteriostatic antibiotics (protein synthesis inhibitors)? - CORRECT
ANSWER-macrolides
aminoglycosides
tetracyclines
clindamycin
linezolid
quinupristin, dalfopristin
what is the MOA of penicillins, cephalosporins, carbapenems, and vancomycin? -
CORRECT ANSWER-cell wall inhibitors - bactericidal
,what general ADRs are the black box warning for aminoglycosides? - CORRECT
ANSWER-nephrotoxicity and neurotoxicity
what are the aminoglycosides? - CORRECT ANSWER-tobramycin
gentamicin
amikacin
what type of nephrotoxicity do aminoglycosides cause? - CORRECT ANSWER-ATN -
acute tubular necrosis
what weight do you use to dose aminoglycosides? - CORRECT ANSWER-IBW (unless
TBW is less)
*use ABW if obese ( > 30% IBW)
what organisms are aminoglycosides mainly active against? - CORRECT ANSWER-
gram (-): GNR, PA
extended interval dosing of the aminoglycosides? - CORRECT ANSWER-gent/tobra: 4-
7 mg/kg
amikacin: 15-20 mg/kg
*draw random level within 6-16 hours after dose
adjust body weight (ABW) formula? - CORRECT ANSWER-IBW + [0.4(TBW - IBW)]
desired trough (traditional dosing) for gent/tobra? peak? - CORRECT ANSWER-trough:
< 2 mcg/mL
peak: 5-10 mcg/mL
amoxicilin brand name - CORRECT ANSWER-Amoxil
, what organisms do the penicillins cover? - CORRECT ANSWER-mainly gram (+), some
gram (-)
which penicillin is the DOC in acute otitis media? - CORRECT ANSWER-amoxicillin
which penicillin has activity against PA? - CORRECT ANSWER-piperacillin
which penicillins do not require renal dosing? - CORRECT ANSWER-nafcillin
oxacillin
dicloxacillin
Does Amoxil suspension need to be refrigerated? - CORRECT ANSWER-no - stable for
14 days at room temperature
how do you need to take Pen VK? - CORRECT ANSWER-on an empty stomach
what IV fluid is ampicillin only compatible with? - CORRECT ANSWER-NS
what are the main penicillin drug interactions? - CORRECT ANSWER-probenacid,
allopurinol - increased penicillin levels
may decrease levels of oral contraceptives
what type of killing do cephalosporins exhibit? - CORRECT ANSWER-time-dependent
what are the first generation cephalosporins? - CORRECT ANSWER-cefazolin and
cephalexin
what organisms are every cephalosporin active against? - CORRECT
ANSWER-strep/staph and GNR
Questions With Accurate Solutions
Rated A+!!
MIC - CORRECT ANSWER-lowest drug concentration that prevents visibile microbial
growth in 24 hours
gram (+) bacteria species - CORRECT ANSWER-staph, strep, EC, clostridium, listeria
which antibiotics exhibit time-dependent killing? - CORRECT ANSWER-penicillins,
cephalosporins
how can you increase the killing of a time-dependent antibiotic? - CORRECT ANSWER-
dose more frequently, extend the infusion time
example of concentration-dependent antibiotic? - CORRECT ANSWER-
aminoglycosides (gentamicin, tobramycin, amikacin)
what are the bacteriostatic antibiotics (protein synthesis inhibitors)? - CORRECT
ANSWER-macrolides
aminoglycosides
tetracyclines
clindamycin
linezolid
quinupristin, dalfopristin
what is the MOA of penicillins, cephalosporins, carbapenems, and vancomycin? -
CORRECT ANSWER-cell wall inhibitors - bactericidal
,what general ADRs are the black box warning for aminoglycosides? - CORRECT
ANSWER-nephrotoxicity and neurotoxicity
what are the aminoglycosides? - CORRECT ANSWER-tobramycin
gentamicin
amikacin
what type of nephrotoxicity do aminoglycosides cause? - CORRECT ANSWER-ATN -
acute tubular necrosis
what weight do you use to dose aminoglycosides? - CORRECT ANSWER-IBW (unless
TBW is less)
*use ABW if obese ( > 30% IBW)
what organisms are aminoglycosides mainly active against? - CORRECT ANSWER-
gram (-): GNR, PA
extended interval dosing of the aminoglycosides? - CORRECT ANSWER-gent/tobra: 4-
7 mg/kg
amikacin: 15-20 mg/kg
*draw random level within 6-16 hours after dose
adjust body weight (ABW) formula? - CORRECT ANSWER-IBW + [0.4(TBW - IBW)]
desired trough (traditional dosing) for gent/tobra? peak? - CORRECT ANSWER-trough:
< 2 mcg/mL
peak: 5-10 mcg/mL
amoxicilin brand name - CORRECT ANSWER-Amoxil
, what organisms do the penicillins cover? - CORRECT ANSWER-mainly gram (+), some
gram (-)
which penicillin is the DOC in acute otitis media? - CORRECT ANSWER-amoxicillin
which penicillin has activity against PA? - CORRECT ANSWER-piperacillin
which penicillins do not require renal dosing? - CORRECT ANSWER-nafcillin
oxacillin
dicloxacillin
Does Amoxil suspension need to be refrigerated? - CORRECT ANSWER-no - stable for
14 days at room temperature
how do you need to take Pen VK? - CORRECT ANSWER-on an empty stomach
what IV fluid is ampicillin only compatible with? - CORRECT ANSWER-NS
what are the main penicillin drug interactions? - CORRECT ANSWER-probenacid,
allopurinol - increased penicillin levels
may decrease levels of oral contraceptives
what type of killing do cephalosporins exhibit? - CORRECT ANSWER-time-dependent
what are the first generation cephalosporins? - CORRECT ANSWER-cefazolin and
cephalexin
what organisms are every cephalosporin active against? - CORRECT
ANSWER-strep/staph and GNR
