Maryville NUR 611 Patho Exam 3 | 100% Correct | Verified | 2024 Version

Explain the pathophysiology associate with Type 1 and Type 2 DM. DM 1 - Is the result of an autoimmune mediated specific loss of beta cells in the pancreatic islet. One of the basic patho of type 2 DM is the development of insulin resistant tissue cells. Explain what occurs in panhypopituitarism - Panhypopituitarism is the term correctly associated with the lack of all anterior pituitary hormones. List the clinical manifestations of hypothyroidism - The individual develops a low basal metabolic rate, cold intolerance, lethargy, tiredness, and slightly lower basal body temperature. Differentiate diabetes insipidus, diabetes mellitus and SIADH - DM: is not a single disease but a group of clinical heterogeneous disorders that have glucose intolerance in common. DI: is an insufficiency of ADH, leading to polyuria and polydipsia. SIADH: is characterized by high levels of ADH in the absence of normal physiologic stimuli for its release. The symptom common to all these conditions is thirst. What causes the microvascular complications of DM - Microvascular complications are a result of capillary basement membranes thickening and endothelial cell hyperplasia. What is the cause of diabetes insipidus - Inability of the kidney to increase permeability of water. This causes excretions of large volumes of dilute urine, leading to increase in plasma osmolality. Describe the pathophysiological changes associated with Addison's disease - Addison disease is a result of hyposecretion of adrenal cortex hormones. Describe the pathophysiological changes associated with hypoparathyroidism - The most common cause of hyperparathyroidism is damage caused during thyroid surgery. In hypothyroidism a lack of circulating PTH causes a depressed serum calcium level resulting in the symptomatology mentioned in the stem.