NR 546 Antipsychotics Table Week 3 Assignments.

blocking of D2 receptors in the pituitaryWorks by blocking D2 receptors●Neuroleptic-induced deficit syndrome-linked to blockade of D2 receptors in themesolimbic and mesocortical pathways●Dry mouth, blurred vision, urinaryretention, consitpation, and paralytic ileus-linked to the blockade of muscariniccholinergic receptors●Sedation and weight-gain- linked toantihistamine actions●Dizziness, hypotension, and syncope- linkedto inadvertent blockade of alpha 1adrenergic receptors●Dose-dependent QTc prolongation- possiblylinked to actions at ion channelsThiothixeneDopamine 2 AntagonistInitial: 3.4●Akathisia, dystonia, and drug-inducedhoursparkinsonism- linked to blockade of D2receptors in the striatumTerminal: 34Targets the positive symptoms of psychosis inhours●Tardive dyskinesia- linked to chronicschizophrenia, can also be used for other psychoticblockade of D2 receptors in the striatumdisorders and bipolar disorder●Galactorrhea/amenorrhea- linked toCYP450blocking of D2 receptors in the pituitaryunknownWorks by blocking D2 receptors to reduce positive●Neuroleptic-induced deficit syndrome-symptoms, also has some effect on serotoneric receptorslinked to blockade of D2 receptors in themesolimbic and mesocortical pathways●Dry mouth, blurred vision, urinary retention, constipation, and paralytic ileus-linked to the blockade of muscariniccholinergic receptors●Sedation and weight-gain- linked toantihistamine actions●Dizziness, hypotension, and syncope- linkedto inadvertent blockade of alpha 1adrenergic receptorsFluphenazineDopamine 2 AntagonistOral: 15●Akathisia, dystonia, and drug-inducedhoursparkinsonism- linked to blockade of D2receptors in the striatumIM: 6.8-9.6Targets the positive symptoms of psychosis. Commonlydays●Tardive dyskinesia- linked to chronicused for schizophrenia and can be used in bipolarblockade of D2 receptors in the striatumdisorder.●Galactorrhea/amenorrhea- linked toCYP450 2D6blocking of D2 receptors in the pituitaryWorks by blocking D2 receptors in the mesolimbic●Neuroleptic-induced deficit syndrome-pathway, specifically post-synaptic receptorslinked to blockade of D2 receptors in themesolimbic and mesocortical pathways●Dry mouth, blurred vision, urinaryretention, constipation, and paralytic ileus-linked to the blockade of muscariniccholinergic receptors●Sedation and weight-gain- linked toantihistamine actions●Dizziness, hypotension, and syncope- linkedto inadvertent blockade of alpha 1 may contribute to improvement in cognitive/affectiveto conventional antipsychotics)symptoms.AsenapineDopamine-Serotonin-Norepinephrine Receptor13-39 hours●Drug-induced parkinsonism, , andAntagonistakathisia- linked to acute blockade of D2receptors in the striatumInhibits●Tardive dyskinesia- linked to chronicTargets the of for reductionCYP450 2D6blockade of D2 receptors in the striatumand stabilizes affective symptoms. Commonly used for in adults, acute /mixed mania in●Dizziness, hypotension, and syncope- linkedages 10 years and older, can be used as an adjunct toto blockade of alpha 1 adrenergic receptorsSubstratelithium or valproate for acute mania/mixed main infor CYP450●Increased risk for diabetes andadults, and maintenance in adults.1A2dyslipidemia- link unknown●Application site reactions (oral ulcers,Works by blocking D2 receptors to reduce the positivepeeling/sloughing, inflammation, blisterssymptoms of and stabilizing affectivefor sublingual, and irritation/burning forsymptoms, blocks serotonin 2A receptors to enhancetransdermal)dopamine release in certain areas of the brain to reducemotor side effects and improve cognitive/negativesymptoms, actions on the serotonin 1A receptors maycontribute to improvement in cognitive/affectivesymptoms as well as lessening anxiety and increasingpositive mood, actions on serotonin 2C, 7, and it's alpha2 antagonist properties may contribute to theantidepressant actions.ClozapineDopamine-Serotonin-Norepinephrine Receptor5-16 hours●Dizziness, hypotension, and syncope- linkedAntagonistto blockade of alpha 1 adrenergic receptors●Dry mouth, blurred vision, urinaryCYP450 1A2retention, constipation, and paralytic ileus-Targets the positive and of(primary)linked to blockade of muscarinic