Chemotherapy/Immunotherapy Certificate Course (ONS,ONCC) In-class activity

Chemotherapy/Immunotherapy Certificate Course (ONS,ONCC) In-class activity Alkylating agents - ANS Classification Break DNA helix strand, thereby interfering with DNA replication Altretamine (Hexalen) - ANS Alkylating Agent PO Ovarian CA Side effects- nausea, vomiting, skin rash, hypersensitivity reaction, diarrhea Dose limiting - neuro-toxicity, peripheral neuropathy, myelosuppression Bendamustine (Treanda/Bendeka) - ANS Alkylating agent IV CLL or Indolent NHL Side effects- pyrexia, nausea, vomiting, skin reactions, TLS, hepatotoxicity, vein irritation Dose limiting - myelosuppression Irritant and vesicant properties infusion reactions likely to occur in 2nd or subsequent infusions Busulfan (IV busulfex: PO Myleran) - ANS Alkylating Agent IV or PO CML and Stem cell prep Side effects - profound tachycardia, HTN, chest pain, hyperpigmentation, alopecia, infertility, confusion, suizures, mucositis, nausea, vomiting, insomnia, hyperglycemia, blurred vision, secondary malignancy, VOD (now sinusoidal obstruction syndrome) seizure prophylaxis central line only for IV Carboplatin - ANS Alkylating agent