NURS 6630 / NURS6630 APPROACHES TO TREATMENT WEEK 11 FINAL EXAM. QUESTIONS WITH WELL EXPLAINED ANSWERS.

Question 47 T. B. is a 55-year-old male who has diagnosed with type 2 diabetes 10+ years ago. He has since had complications from the disease and is suffering from severe neuropathy. On top of that, T. B. is struggling with his mental health and was recently told he could be depressed but he had refused treatment at that time. Besides getting his blood sugar under control, what medication(s) can we use that may be useful in helping T. B.? I. Nortriptyline II. Venlafaxine III. Duloxetine IV. Fluoxetine A. I, II, and III B. I and II C. II and III D. IV only Response Feedback: “Among the antidepressants these include the TCAs and SNRIs (duloxetine and venlafaxine).” - SSRIs – page 204: “There is little evidence to support the independent analgesic activity of SSRIs.” Question 48 Disulfiram has been proven effective in the treatment of alcoholism, but recently it has been trialed in the management of cocaine addiction. What is the mechanism of action that likely helps produce these aversive effects? A. Inhibition on dopamine beta-hydroxylase B. Inhibition on aldehyde dehydrogenase C . Inhibition on alcohol dehydrogenase D . Inhibition on aldehyde reductase Response Feedback: “These reactions are thought to be mediated by the inhibitory effect of disulfiram on dopamine beta-hydroxylase. This action will elevate depleted plasma dopamine levels in chronic users and will produce abnormally high dopamine levels if cocaine is ingested; this results in a dysphoric experience in most users.” Question 49 SSRIs can be used in alcohol use disorder and offer modest drinking reduction through an anti-craving effect. A. True B. False Response Feedback: “SSRIs have produced only modest drinking reductions— independent of the antidepressant effects—through an anti-craving effect” Question 50 Which of the following drugs in the treatment of Alzheimer’s Disease helps normalize glutamate by antagonizing the NMDA receptor? A. Memantine B. Donepezil C. Rivastigmine D. Galantamine