Care Man 4 Exam 2 Antibiotics Burns Shock and Musculoskeletal trauma

Bacteriostatic (inhibits) o inhibits growth of Bacteria by preventing bacteria from multiplying and then hosts defences deal with the small number of bacteria left  Bactericidal (kills) o kills Bacteria, so eliminates bacteria  Principles of Antibiotic Guidelines o Specimens for microbiology should be taken prior to the start of empiric Abx treatment. o In an emergency, at a minimum a set of blood cultures should be taken (meningitis). o Ensure any history of allergy is documented on the cover of notes and drug kardex prior to commencing antibiotics o 2 lab specimens should be collected o In case something happens to the first one (contamination) o 2 different sticks from 2 different locations o 12 hours before the results come back o Patient is started on a broad antibiotic while awaiting test results  Switched to a culture specific antibody when test results return o Use chlorohexidine to prep site  Principles of Antibiotic Guidelines o Empiric antibiotics should be reviewed once labs have resulted. o Empiric therapy should be changed to directed therapy as soon as possible. o Directed therapy should be the narrowest spectrum antibiotic to adequately cover the pathogens  Definitions o Pharmacokinetics: Mathematical study of the rate process involved in absorption, distribution, metabolism and excretion o Pharmacodynamics: Time course of drug effects and other interactions between antimicrobials and the bacterium  Principles of Antibiotic Guidelines o Pharmacokinetics&Pharmacodynamics issues may necessitate dose adjustments