Lehne's Pharmacology for Nursing
Care
12th Edition
• Author(s)Jacqueline Rosenjack
Burchum; Laura D. Rosenthal
,TEST BANK
Question 1 – MCQ
Clinical Scenario
A nurse is caring for a patient newly diagnosed with
hypertension. The patient asks why one medication works well
for a neighbor but may not work the same way for them.
Question Stem
Which factor best explains why individuals may experience
different responses to the same medication?
Answer Options
A. All patients metabolize medications at identical rates.
B. Drug responses are influenced by genetic, physiologic, and
environmental factors.
C. Medication effects are determined only by dosage.
D. Drug responses are unaffected by age.
Correct Answer
B. Drug responses are influenced by genetic, physiologic, and
environmental factors.
,Detailed Rationale
Drug response variability results from numerous factors
including genetics, age, organ function, disease states, nutrition,
concurrent medications, and environmental influences.
Pharmacogenomic differences can alter drug metabolism and
receptor responsiveness, leading to variation in therapeutic and
adverse effects among individuals.
Understanding individual variability supports safe, patient-
centered pharmacotherapy and prevents assumptions that a
medication will affect every patient identically.
Incorrect Option Analysis
A. All patients metabolize medications at identical rates
Why Incorrect: Metabolism varies significantly among
individuals.
Common Misconception: Drug processing is uniform.
Safety Risk: Increases risk for toxicity or undertreatment.
Nursing Consideration: Assess factors affecting metabolism.
C. Medication effects are determined only by dosage
, Why Incorrect: Dose is only one factor influencing response.
Common Misconception: Higher doses always produce better
outcomes.
Safety Risk: Overdose or adverse reactions.
Nursing Consideration: Consider patient-specific variables.
D. Drug responses are unaffected by age
Why Incorrect: Age significantly influences pharmacokinetics
and pharmacodynamics.
Common Misconception: Adult dosing applies equally to all
ages.
Safety Risk: Increased adverse effects in pediatric and geriatric
patients.
Nursing Consideration: Adjust monitoring according to age-
related changes.
Nursing Process Linkage
Assessment
NCJMM Competencies
Care
12th Edition
• Author(s)Jacqueline Rosenjack
Burchum; Laura D. Rosenthal
,TEST BANK
Question 1 – MCQ
Clinical Scenario
A nurse is caring for a patient newly diagnosed with
hypertension. The patient asks why one medication works well
for a neighbor but may not work the same way for them.
Question Stem
Which factor best explains why individuals may experience
different responses to the same medication?
Answer Options
A. All patients metabolize medications at identical rates.
B. Drug responses are influenced by genetic, physiologic, and
environmental factors.
C. Medication effects are determined only by dosage.
D. Drug responses are unaffected by age.
Correct Answer
B. Drug responses are influenced by genetic, physiologic, and
environmental factors.
,Detailed Rationale
Drug response variability results from numerous factors
including genetics, age, organ function, disease states, nutrition,
concurrent medications, and environmental influences.
Pharmacogenomic differences can alter drug metabolism and
receptor responsiveness, leading to variation in therapeutic and
adverse effects among individuals.
Understanding individual variability supports safe, patient-
centered pharmacotherapy and prevents assumptions that a
medication will affect every patient identically.
Incorrect Option Analysis
A. All patients metabolize medications at identical rates
Why Incorrect: Metabolism varies significantly among
individuals.
Common Misconception: Drug processing is uniform.
Safety Risk: Increases risk for toxicity or undertreatment.
Nursing Consideration: Assess factors affecting metabolism.
C. Medication effects are determined only by dosage
, Why Incorrect: Dose is only one factor influencing response.
Common Misconception: Higher doses always produce better
outcomes.
Safety Risk: Overdose or adverse reactions.
Nursing Consideration: Consider patient-specific variables.
D. Drug responses are unaffected by age
Why Incorrect: Age significantly influences pharmacokinetics
and pharmacodynamics.
Common Misconception: Adult dosing applies equally to all
ages.
Safety Risk: Increased adverse effects in pediatric and geriatric
patients.
Nursing Consideration: Adjust monitoring according to age-
related changes.
Nursing Process Linkage
Assessment
NCJMM Competencies
