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Exam (elaborations)

HESI Pathophysiology Study Guide 2026 | Updated Practice Questions & Rationales for Success

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HESI Pathophysiology Study Guide 2026 | Updated Practice Questions & Rationales for Success This HESI Pathophysiology Study Guide is fully updated for 2026 and aligned with current exam content, designed to support effective and ethical exam preparation. It includes high-yield practice questions with detailed explanations and core concepts to help strengthen understanding. Ideal for nursing students seeking confidence and readiness for the HESI exam.

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Uploaded on
December 31, 2025
Number of pages
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Written in
2025/2026
Type
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Hesi Pathophysiology Practice Exam (NEW UPDATED VERSION) LATEST
ACTUAL EXAM QUESTIONS AND CORRECT ANSWERS (VERIFIED QUESTIONS AND
ANSWERS) | GUARANTEED PASS A+ UPDATED THIS YEAR




After talking w/ the HCP, a male pt continues to have questions about the results
of a prostatic surface antigen (PSA) screening test and asks the nurse how the PSA
levels become elevated. The nurse should explain which pathophysiological
mechanism? - CORRECT ANSWER As the prostate gland enlarges, its
cells contribute more PSA in the circulating blood

PSA is a glycoprotein found in prostatic epithelial cells, and elevations are used as
a specific tumor markers. Elevations in PSA are r/t gland volume, ie. benign BPH,
prostatitis, and cancer of the prostate, indicating tumor cell load. PSA levels are
also used to monitor response to therapy

QUESTION :A 26 yr old male client w/ Hodgkin's disease is scheduled to undergo
radiation therapy. The clinet expresses concern about the effect of radiation on his
ability to have children. What info should the nurse provide? - CORRECT
ANSWER Permanent sterility occurs in the male client who receive radiation

Low sperm count and loss of motility are seen in males w/ Hodgkin's disease b/f
any therapy. Radiotherapy often results in permanent aspermia, or sterility

QUESTION :The nurse hears short, high-pitched sounds just b/f the end of
inspiration in the right and left lower lobes when auscultating a client's lungs. How
should this finding be recorded? - CORRECT ANSWER Crackles in the
right and left lower lobes

Fine crackles - short, high-pitched sounds heard just b/f the end of inspiration that
are the result of rapid equalization of pressure when collaped alveoli or terminal
bronchioles suddenly snap open




2026 2027 GRADED A+

, 2|Page


Wheezing is a continuous high-pitched squeaking or musical sound caused by
rapid vibration of bronchial walls that are 1st evident on expiration and may be
audible

QUESTION :A client is admitted to the ER w/ a tension pneumothorax. Which
assessment should the nurse expect to ID? - CORRECT ANSWER A
deviation of the trachea toward the side opposite of the pneumothorax

Tension pneumothorax is caused by rapid accumulation of air in the pleural space,
causing severely high intrapleural pressure. This results in collapse of the lung, and
the mediastinum shifts toward the unaffected side, which is subsequently
compressed

QUESTION :A client who is receiving a whole blood transfusion dv's chills, fever,
and a HA 30 min after the transfusion is started. The nurse shold recognize these
sx as characteristic of what rxn? - CORRECT ANSWER A febrile
transfusion reaction

Sx of a febrile reaction include sudden chills, fever, HA, flushing, and muscle pain.

An allergic rxn is the response of histamine release which is characterized by
flushing, itching, and urticaria. It exhibits an exaggerated allergic response that
progresses to shock and possible cardiac arrest

an acute hemolytic reaction presents w/ fever, chills, but is hallmarked by the
onset of low back pain, tachycardia, tachypnea, vascular collapse, hemoglobinuria,
dark urine, ARF, shock, cardiac arrest, and even death

QUESTION :The nurse is analyzing the waveforms of a client's ECG. What finding
indicates a disturbance in electrical conduction in the ventricles? - CORRECT
ANSWER QRS interval of 0.14 second

the normal duration of the QRS is 0.04 - 0.12 sec

T wave is 0.16 sec;
PR is 0.12 - 0.20 sec;
QT is 0.31-0.38 sec

2026 2027 GRADED A+

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