Marelilya

Comprehensive lecture notes for the course Advanced Light Microscopy

This document provides detailed lecture notes on host-microbe interactions, covering the human microbiota and microbiome, their role in digestion, immunity, metabolism, and disease. Topics include the Human Microbiome Project, methods of microbiota identification (16S rRNA sequencing, metagenomics), early-life microbiome development, mucosal immunity, diet–microbiome interactions, inflammatory bowel disease, autoimmunity, the gut-brain axis, probiotics, and drug metabolism. The material integr...

This document contains the lecture notes for the course Hematopoietic Stem Cells, Differentiation and Development. It concerns topics on hematopoietic stem cells, their differentiation, and development, including detailed insights into blood cell lineages, leukemogenesis, epigenetics, immunotherapy, and bone marrow diagnostics. It also covers hematological disorders such as anemia, thalassemia, sickle cell disease, chronic myeloid leukemia, multiple myeloma, acute lymphoblastic leukemia, chronic...

Lecture notes on the Bsc course Food and Metabolism

This document provides an overview of the molecular and cellular basis of cancer, from its origin in mutations to its progression and treatment. It explains how cancer arises through the accumulation of genetic and epigenetic changes, including activation of oncogenes and loss of tumor suppressor genes. Key processes such as apoptosis, angiogenesis, metastasis, immune evasion, and epigenetic regulation are described, along with the roles of noncoding RNAs and signaling pathways in tumor developm...

This is a summary of molecular toxicology based on Boelsterli, U. A. (2007). Mechanistic Toxicology: The Molecular Basis of How Chemicals Disrupt Biological Targets. It covers the molecular mechanisms by which chemicals and drugs can cause toxicity in humans and animals. Topics include: Basic principles of toxicology: dose-dependence, exposure routes, toxicokinetics (absorption, distribution, metabolism, excretion) and toxicodynamics (interaction with cellular targets). Biological resp...