Genetic polymorphisms account for differences in metabolism, including:

1. Poor metabolizers, who lack a working enzyme

2. Intermediate metabolizers, who have one working, wild-type allele and one mutant allele

3. Extensive metabolizers, with two normally functioning alleles

4. All of the above

4. All of the above

Up to 21% of Asians are ultra-rapid 2D6 metabolizers, leading to:

1. A need to monitor drugs metabolized by 2D6 for toxicity

2. Increased dosages needed of drugs metabolized by...
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