What are the 3 phases of chronic myelogenous leukemia (CML)? -

1. Chronic (increase in WBCs or Plts and splenomegaly, "stable phase" lasting 1-4 years)

2. Accelerated phase ( ~ few months)

3. Blast phase (transition to ACUTE leukemia)

What is the ONLY CURE for CML? - Allogeneic HSCT (stem cell transplant)

When is AHSCT indicated? - Blast crisis

accelerated phase

unresponsive or intolerant to TKIs

What is the purpose of TKIs in treating CML? - To maintain patient in the chronic phase ...
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