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PTxIII Cancer Exam 4 | 100% Correct Answers | Verified | Latest 2024 Version
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What are the 3 phases of chronic myelogenous leukemia (CML)? - 1. Chronic (increase in WBCs or Plts and splenomegaly, "stable phase" lasting 1-4 years) 2. Accelerated phase ( ~ few months) 3. Blast phase (transition to ACUTE leukemia) What is the ONLY CURE for CML? - Allogeneic HSCT (stem cell transplant) When is AHSCT indicated? - Blast crisis accelerated phase unresponsive or intolerant to TKIs What is the purpose of TKIs in treating CML? - To maintain patient in the chronic phase "stable phase" Which 5 TKIs are approved for CML? Hint: I DONT NEED BLOOD PUNK - Imatinib Dasatinib Nilotinib Bosutinib Ponatinib
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