A 3-year-old boy with recurrent infections, absent tonsils, and low T-cell

numbers is most likely to have a defect in which organ?

A. Bone marrow

B. Thymus

C. Spleen

D. Lymph nodes

E. Liver

B. Thymus

Rationale: Thymic aplasia (e.g., DiGeorge) causes T-cell lymphopenia

and recurrent infections; the thymus is essential for T-cell maturation.

2. Mutations that convert a proto-oncogene into an oncogene are typically:

A. Loss-of-function frameshift mutations

B. Gain-of-function point mu...
verified BARKLEY PMHNP 2026 Ultimate Exam Review: 150 High-Yield 
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