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USMLE STEP 1 GASTROINTESTINAL Questions and Answers with Complete Solutions 2024
- Exam (elaborations) • 61 pages • 2023
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USMLE STEP 1 GASTROINTESTINAL 
Questions 
and Answers with Complete Solutions 2024 
Foregut - ANSPharynx to duodenum 
Midgut - ANSDuodenum to proximal 2/3 of transverse colon 
Hindgut - ANSDistal 1/3 of transverse colon to anal canal above pectinate line 
Abnormal Rostral Fold Closure - ANSDevelopmental defect of anterior 
abdominal wall that leads to STERNAL DEFECTS 
Abnormal Lateral Fold Closure - ANSDevelopmental defect of anterior 
abdominal wall that leads to OMPHALOCELE, GASTROSCHISIS 
Abn...
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USMLE STEP 1 FIRST AID Questions and Answers with Complete Solutions 2024
- Exam (elaborations) • 131 pages • 2023
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USMLE STEP 1 FIRST AID Questions 
and Answers with Complete Solutions 2024 
polyostotic fibrous dysplasia, precocious puberty, cafe-au-lait spots, short stature, 
young girls - diagnosis? - ANSAlbright's syndrome 
blue-domed cysts - diagnosis? - ANSfibrocystic change of the breast 
Wermer's syndrome - also known as? - ANSMEN type I 
"wire loop" appearance on Light microscopy- diagnosis? - ANSlupus 
nephropathy 
what is the defect in Job's syndrome? - ANSneutrophil chemotaxis abnormality 
- ...
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USMLE STEP 1 EQUATIONS Questions and Answers with Complete Solutions 2024
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USMLE STEP 1 EQUATIONS Questions 
and Answers with Complete Solutions 2024 
Sensitivity - ANSSensitivity = TP / (TP + FN) 
Specificity - ANSSpecificity = TN / (TN + FP) 
Positive predictive value - ANSPPV = TP / (TP + FP) 
Negative predictive value - ANSNPV = TN / (TN + FN) 
Relative risk - ANSRR= (a/[a+b]) / (c/[c+d]) 
Attributable risk - ANSAR= (a/[a+b]) - (c/[c+d]) 
Number needed to treat - ANS1/absolute risk reduction 
Number needed to harm - ANS1/attributable risk 
Hardy-Weinberg equilibriu...
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USMLE STEP 1 ENDOCRINOLOGY Questions and Answers with Complete Solutions 2024
- Exam (elaborations) • 35 pages • 2023
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USMLE STEP 1 ENDOCRINOLOGY 
Questions 
and Answers with Complete Solutions 2024 
what is the embryonal origin of the adrenal cortex? - ANSmesoderm 
what is the embryonal origin of the adrenal medulla? what are the cells of the 
adrenal medulla called? - ANSneural crest; chromaffin cells 
T/F the chromaffin cells of the adrenal cortex are are considered preganglionic - 
ANSfalse- postganglionic and ganglionic sympathetic 
what autonomic is the adrenal medulla innervated by? what are the NT? what ...
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USMLE STEP 1 Disorders of Metabolism Questions and Answers with Complete Solutions 2024
- Exam (elaborations) • 7 pages • 2023
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USMLE STEP 1 Disorders of Metabolism 
Questions and Answers with Complete 
Solutions 2024 
Pyruvate Dehydrogenase Complex Deficiency - ANSbuildup of pyruvate, 
which gets shunted to alanine (via ALT) and lactase (via LDH) 
Treatment of Pyruvate Dehydrogenase Complex Deficiency - ANSlysine and 
leucine 
G6PD Deficiency - ANSabsence of G6PD leads to NADPH deficiency -> 
NADPH deficiency leads to inability to reduce glutathione via glutathione 
reductase -> 
No reduced glutathione means no de...
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USMLE STEP 1 Biostatistics/Epidemiology Questions and Answers with Complete Solutions 2024
- Exam (elaborations) • 4 pages • 2023
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USMLE STEP 1 Biostatistics/Epidemiology 
Questions and Answers with Complete 
Solutions 2024 
Sensitivity - ANSTP / (TP + FN) 
Specificity - ANSTN / (TN + TP) 
Positive Predictive Value - ANSTP / (TP + FP) 
Negative Predictive Value - ANSTN / (FN + TN) 
Incidence Rate - ANS# of new cases in a certain time period / population that is 
at risk during that time period 
This looks at new incidences occurring during a time period 
Prevalence - ANS# of existing cases / population at risk 
Looks at ALL...
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USMLE STEP 1 BIOCHEMISTRY Questions and Answers with Complete Solutions 2024
- Exam (elaborations) • 16 pages • 2023
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USMLE STEP 1 BIOCHEMISTRY 
Questions and Answers with 
Complete Solutions 2024 
Achondroplasia involves what defect? - ANSCell-signlaling defect of 
fibroblast growth factor (FGF) receptor 3 
Marfan's syndrome involves a mutation in what? - ANSFibrillin gene 
Nucleoside + phosphate= ? - ANSNucleotide 
Adenine and Guanine are in what type of nucleic acid? - ANSPurines 
Cytosine, Uracil and Thyamine arein what kind of nucleic acid? - 
ANSPyrimidines 
Xanthine, hypoxanthine and uric acid are all w...
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USMLE STEP 1 BIOCHEMISTRY Questions and Answers with Complete Solutions 2024
- Exam (elaborations) • 80 pages • 2023
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USMLE STEP 1 BIOCHEMISTRY 
Questions and Answers with 
Complete Solutions 2024 
histones are rich in which 2 AA's - ANSlysine & argenine 
Barr bodies (what, type of chromatin) - ANSinactive X chromosomes 
heterochromatin (highly condensed, sterically inaccessible) 
less condensed, transcriptionally active, sterically accessible chromatin - 
ANSeuchromatin 
DNA methylation at CpG islands - ANSrepresses transcription 
"CpG Methylation makes DNA Mute" 
DNA methylation (what is methylated and why...
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USMLE STEP 1 AUTOANTIBODIES Questions and Answers with Complete Solutions 2024
- Exam (elaborations) • 2 pages • 2023
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USMLE STEP 1 AUTOANTIBODIES 
Questions 
and Answers with Complete Solutions 2024 
Anti-ACh receptor - ANSMyasthenia Gravis 
Anti-Basement Membrane - ANSGoodpasture Syndrome 
Anticardiolipin - ANSSLE (antiphospholipid syndrome) 
Anticentromere - ANSCREST Scleroderma 
Anti-Desmosome - ANSPemphigus Vulgaris 
Anti-Desmoglein - ANSPemphigus Vulgaris 
Anti-dsDNA - ANSSLE, specific 
anti-Smith - ANSSLE, specific 
ANti-Glutamic Acid Decarboxylase - ANST1DM 
Antihemidesmosome - ANSBullous
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USMLE STEP 1 ANTIBIOTIC Questions and Answers with Complete Solutions 2024
- Exam (elaborations) • 13 pages • 2023
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USMLE STEP 1 ANTIBIOTIC Questions 
and Answers with Complete Solutions 2024 
Penicillin mechanism - ANSbinds to penicillin binding proteins in 
peptidoglycan (blocks transpeptidase crosslinking); activates autolytic enzymes 
penicillin use - ANSgram positives and syphilis 
penicillin toxicity - ANShypersensitivity reactions, hemolytic anemia 
penicillinase resistant penicillins - ANSmethicillin, nafcillin, dicloxacillin 
penicillinase resistant penicillin use - ANSStaph aureus 
penicillin resist...
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