- Study guides, Class notes & Summaries

MRCP Part 1 Mock Examination Latest Update 100 Professionally Written Practice Questions • Detailed Answer Explanations • Scenario-Based Questions • Covers All Major Exam Objectives • Ideal For Self-Study And Final Review

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36 pages

Written in 2025/2026

Grade A+

elitemindsA

Mrcp part 1 Exam Questions and answers Conns syndrome clinical features - Hypertension (aldosterone induced na retention with increase in ecf volume) -muscle weakness (due to decreased K) -muscle paralysis (severe hypokalaemia) -latent tetany and paraesthesia -polydypsia, polyuria and nocturia (due to hypokalaemia nephropathy) Hypokalaemia WITH hypertension - Cushings syndrome Conns syndrome (primary hyperaldostenoism)

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4 pages

Written in 2025/2026

Grade A+

Wisegrades

MRCP PART 1 PRACTICE EXAMINATION 2026–2027 — STUDY GUIDE | LATEST UPDATE 2026/2027 | PRACTICE QUESTIONS AND ANSWERS | EXAM REVIEW | 100% CORRECT ANSWERS | VERIFIED SOLUTIONS | ALREADY GRADED A+

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43 pages

Written in 2026/2027

Grade A

highub

MRCP Part 1: Hematology Exam Questions and answers Beta Thalassaemia Major - absence of beta globulin chains - chromosome 11 Features of Beta Thalassaemia Major - presents in the first year of life with failure to thrive + hepatosplenomegaly - HbA2 & HbF raised - HbA Absent Mx: repeated transfusion Hereditary Spherocytosis - most common hereditary haemolytic anaemia in Europeans - autosomal dominant - defect of red blood cell cytoskeleton - biconcave disc becomes sphere-shaped (SPHER...

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26 pages

Written in 2025/2026

Grade A+

Wisegrades

MRCP PART 1 HAEMATOLOGY AND ONCOLOGY Exam Questions and answers What is the most commonly inherited thrombophilia? - Factor V Leiden What causes facor V leiden? - mutation in factor V resulting in resistance in inactivation of protein C What does protein C do? - inhibits co-factors FVa and FVIIIa What does protein S do? - combines with activated protein C to inhibit co-factors FVa and FVIIIa What does antithrombin III do? - inhibits clotting factors such as FVIIa (thrombin) and FXa...

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62 pages

Written in 2025/2026

Grade A+

Wisegrades

MRCP Part 1 Exam Questions and answers What cardiovascular feature is associated with adult PKD? Mital valve prolapse What is the most common malignancy associated with acanthosjs nigricans? Gastrointestinal adenocarcinoma A lesion in ____________ would cause Broca's aphasia (expressive aphasia) A lesion in posterior aspect of frontal lobe would cause Broca's aphasia (expressive aphasia) A lesion in ____________ would cause Wernickes aphasia (word substitution,neologisms, spe...

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8 pages

Written in 2025/2026

Grade A+

Wisegrades

Mrcp part 1 Exam Questions and answers Conns syndrome clinical features - Hypertension (aldosterone induced na retention with increase in ecf volume) -muscle weakness (due to decreased K) -muscle paralysis (severe hypokalaemia) -latent tetany and paraesthesia -polydypsia, polyuria and nocturia (due to hypokalaemia nephropathy) Hypokalaemia WITH hypertension - Cushings syndrome Conns syndrome (primary hyperaldostenoism) Liddles syndrome 11 beta hydroxyl see deficiency Carbbe...

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4 pages

Written in 2025/2026

Grade A+

Wisegrades

MRCP PART 1 GASTROENTEROLOGY Exam Questions and answers what is the first line treatment for IBS pain? Anti-spasmodic what is the first line treatment for IBS constipation? laxatives but avoid lactulose What is the first line treatment for IBS diarrhoea? loperamide What treatment can be considered if an IBS patient has constipation not responding to conventional laxative? linaclotide When can linaclotide be given for IBS constipation? -optimal or maximum tolerated doses of ...

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59 pages

Written in 2025/2026

Grade A+

Wisegrades

MRCP Part 1 Exam Questions and answers What signs do you get with oculomotor nerve damage? - Down and out, ptosis and mydriasis What do intergrins do? - cell to cell and extracellular matrix What do selectins do? - adhesion of leucocytes to endothelium during inflammation What is fas ligand useful for? - Fas Fas biding starts cascade for apoptosis What is seen in lead and arsenic poisoning? - Basophilic stripping What is the most significant ECG change for pericarditis? - PR depressi...

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35 pages

Written in 2025/2026

Grade A+

Wisegrades

MRCP Part 1 Exam Questions and answers protein affected in marfan's - fibrillin 1 inheritance pattern of marfans - autosomal dominant features of marfans syndrome - abnormal connective tissue tall stature high arched palate aortic aneurysms protein affected in epidermolysis bullosa - laminin V features of epidermolysis bullosa - blistering of skin and mucosa protein affected in alport syndrome - type 4 collagen

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79 pages

Written in 2025/2026

Grade A+

Wisegrades

MRCP Part 1 Exam Questions and answers What cardiovascular feature is associated with adult PKD? Mital valve prolapse What is the most common malignancy associated with acanthosjs nigricans? Gastrointestinal adenocarcinoma A lesion in ____________ would cause Broca's aphasia (expressive aphasia) A lesion in posterior aspect of frontal lobe would cause Broca's aphasia (expressive aphasia) A lesion in ____________ would cause Wernickes aphasia (word substitution,neologisms, spe...

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8 pages

Written in 2025/2026

Grade A+

Wisegrades

Pregnancy and Thyroid Hormone - answer-Pregnancy increases the amount of TBG (thyroid binding globulin) so increases the total thyroxin levels but not free thyroxine Hyperthyroid in pregnancy - answer-Untreated - fetal loss, premature labour, maternal heart failure Graves disease most common HCG can activate TSH receptors - transient gestational hyperthyroid - these fall in trimester 2 & 3 treatment - propylthiouracil in first trimester this can cause hepatic injury carbimazole in 2nd tr...

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285 pages

Written in 2024/2025

Grade A+

TOPDOCTOR