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Hematology: Chronic Leukemias
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Chronic Leukemia/Lymphoma
Chronic Leukemia/Lymphoma
Proliferative pathways activated but cells mature
Retain some of their immune capacity
Often diagnosed on routine physicals
May acquire more mutations to become acute leukemia
Leukemias in Bone Marrow
Leukemias in Bone Marrow
Acute: Lymphoblasts → malignant during Ig/TCR recombination
Chronic: malignant mature lymphocyte still in marrow
Myeloma in Bone Marrow
Myeloma in Bone Marrow
Malignant plasma cells return to bone marrow
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ethiek en deontologie
