Handling Hazardous Drugs Solved Exam Questions and Answers (Complete
Practice Papers), Exams of Laboratory Practices and Management
Why drugs are labeled as hazardous - ANSWERtoxicity risk to healthcare
workers who could come into contact with the drug
Three categories of hazardous drugs - ANSWERantineoplastics
non-antineoplastics (hormones, transplant drugs)
drugs with reproductive risks
Characteristics that make a drug hazardous - ANSWERcarcinogenic
teratogenic
have reproductive toxicity
organ toxicity at low doses
genotoxic (damage DNA and can cause cancer)
NIOSH - ANSWERNational Institute for Occupational Safety and Health
NIOSH duty - ANSWERdetermines which drugs are hazardous
,NIOSH List of Antineoplastic and Other Hazardous Drugs in the Healthcare
Setting
USP and hazardous drugs - ANSWERUSP 800, sets standards on how to work
safely with hazardous drugs
Federally enforcable December 2019
adds to but does not replace 795 and 797
Drugs that require special handling to avoid toxicity to works -
ANSWERAntineoplastics
Drugs with reproductive risks
Hormones
Transplant drugs
Others
Drugs with reproductive risks - ANSWERPregnancy category X
Many category C and D - paroxetine, methotrexate, misoprostol,
mifepristone, ribavirin, 5-alpha reductase inhibitors (dutasteride, finasteride)
Hormones - ANSWERContraceptives
Estradiol
Testosterone
Transplant drugs - ANSWERMycophenolate
Tacrolimus
Cyclosporine
, Everolimus
Sirolimus
Other hazardous drugs - ANSWERcolchicine, dronedarone, fluconazole
spironolactone, risperidone, raloxifene
rasagiline, ziprasidone
Options for managing drugs on the HD list - ANSWERfollow USP Chapter 800
Conduct a risk assessment
Following USP Chapter 800 to manage HD drugs - ANSWERrequired to be
followed if HD is
-manipulated (crushed/split tablets)
-drawing HD into a vial
with any contact with the (pure) active pharmaceutical ingredient (API) of a
hazardous drug
Conducting a risk assessment - ANSWERdetermine the appropriate
procedures for managing the drugs that will be less stringent than USP 800
Practices that result from risk assessments must be documented and
reviewed at least annually to see if they remain useful and if there is still no
risk to staff
Engineering controls - ANSWERContainment primary engineering controls (C-
PEC)
Containment secondary engineering control (C-SEC)
Practice Papers), Exams of Laboratory Practices and Management
Why drugs are labeled as hazardous - ANSWERtoxicity risk to healthcare
workers who could come into contact with the drug
Three categories of hazardous drugs - ANSWERantineoplastics
non-antineoplastics (hormones, transplant drugs)
drugs with reproductive risks
Characteristics that make a drug hazardous - ANSWERcarcinogenic
teratogenic
have reproductive toxicity
organ toxicity at low doses
genotoxic (damage DNA and can cause cancer)
NIOSH - ANSWERNational Institute for Occupational Safety and Health
NIOSH duty - ANSWERdetermines which drugs are hazardous
,NIOSH List of Antineoplastic and Other Hazardous Drugs in the Healthcare
Setting
USP and hazardous drugs - ANSWERUSP 800, sets standards on how to work
safely with hazardous drugs
Federally enforcable December 2019
adds to but does not replace 795 and 797
Drugs that require special handling to avoid toxicity to works -
ANSWERAntineoplastics
Drugs with reproductive risks
Hormones
Transplant drugs
Others
Drugs with reproductive risks - ANSWERPregnancy category X
Many category C and D - paroxetine, methotrexate, misoprostol,
mifepristone, ribavirin, 5-alpha reductase inhibitors (dutasteride, finasteride)
Hormones - ANSWERContraceptives
Estradiol
Testosterone
Transplant drugs - ANSWERMycophenolate
Tacrolimus
Cyclosporine
, Everolimus
Sirolimus
Other hazardous drugs - ANSWERcolchicine, dronedarone, fluconazole
spironolactone, risperidone, raloxifene
rasagiline, ziprasidone
Options for managing drugs on the HD list - ANSWERfollow USP Chapter 800
Conduct a risk assessment
Following USP Chapter 800 to manage HD drugs - ANSWERrequired to be
followed if HD is
-manipulated (crushed/split tablets)
-drawing HD into a vial
with any contact with the (pure) active pharmaceutical ingredient (API) of a
hazardous drug
Conducting a risk assessment - ANSWERdetermine the appropriate
procedures for managing the drugs that will be less stringent than USP 800
Practices that result from risk assessments must be documented and
reviewed at least annually to see if they remain useful and if there is still no
risk to staff
Engineering controls - ANSWERContainment primary engineering controls (C-
PEC)
Containment secondary engineering control (C-SEC)
