MCAT101 AAMC FL1 Biology 2025
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Given a table showing WT = 25% cell death. WT+E9= 50% cell death.
Based on the data presented in the passage, which statement best
describes the HSP110ΔE9 allele?
A.Cancer-promoting and dominant to HSP110WT
B. Cancer-promoting and recessive to HSP110WT
C. Cancer-suppressing and dominant to HSP110WT
D. Cancer-suppressing and recessive to HSP110WT - 🧠ANSWER ✔✔C.
Cancer-suppressing and dominant to HSP110WT
,On graph, E9 decreases tumor volume, thus suppressing WT. On table
adding E9+WT increases cell death (decrease tumors) over just WT alone
thus is dominant
Given the table as T17 deletion increase, E9 (inhibits WT/tumor)
expression increases.
Based on the passage, in MSI CRC primary tumor cells, the size of the
deletion in the HSP110 T17 microsatellite is inversely correlated with:
A. the amount of HSP110ΔE9 protein expressed.
B. the number of mature HSP110WT transcripts synthesized.
C. the frequency of the omission of HSP110 Exon 9 during splicing.
D. the extent of premature translation termination in Exon 10. - 🧠ANSWER
✔✔B. the number of mature HSP110WT transcripts synthesized.
increase deletions, increase E9, decrease WT, decrease tumors
,*this is a double negative (increase suppressor), draw the relation out with
(^v) arrows
Given that CRC mutation is a mismatch in DNA replication and E9
expression is only in cancerous tissue.
A man with a CRC mutation that results in the synthesis of HSP110ΔE9
(has cancer tissue) and a woman that does not carry this mutation in any of
her tissues have a child. What is the percent chance that the child will
inherit the CRC mutation?
A. 0%
B. 25%
C. 50%
D. 100% - 🧠ANSWER ✔✔A. 0%
The CRC mutation is a malfunction mismatch in cancer cells. The
DNA/gene is not the problem but the process of replication is, so cancer is
not inheritable.
COPYRIGHT©JOSHCLAY 2025/2026. YEAR PUBLISHED 2025. COMPANY REGISTRATION NUMBER: 619652435. TERMS OF USE. PRIVACY
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STATEMENT. ALL RIGHTS RESERVED
, Plus, E9 is only expressed in cancerous/damaged tissue, not in gametes!
(cancer is mostly not inherited but result from damage of the DNA).
*Tricky wording coz mutation=/=genes. Mutation in this case refers to the
mismatch, not a DNA gene mutation! Cancer is not inherited but having
certain genes makes u more susceptible.
Which nucleotide pairing(s) would be recognized by the MMR system
during DNA replication?
I. dTMP and dCMP
II. dGMP and dAMP
III. dAMP and dTMP
A. I only
B. III only
C. I and II only
Expert Verified | Ace the Test
Given a table showing WT = 25% cell death. WT+E9= 50% cell death.
Based on the data presented in the passage, which statement best
describes the HSP110ΔE9 allele?
A.Cancer-promoting and dominant to HSP110WT
B. Cancer-promoting and recessive to HSP110WT
C. Cancer-suppressing and dominant to HSP110WT
D. Cancer-suppressing and recessive to HSP110WT - 🧠ANSWER ✔✔C.
Cancer-suppressing and dominant to HSP110WT
,On graph, E9 decreases tumor volume, thus suppressing WT. On table
adding E9+WT increases cell death (decrease tumors) over just WT alone
thus is dominant
Given the table as T17 deletion increase, E9 (inhibits WT/tumor)
expression increases.
Based on the passage, in MSI CRC primary tumor cells, the size of the
deletion in the HSP110 T17 microsatellite is inversely correlated with:
A. the amount of HSP110ΔE9 protein expressed.
B. the number of mature HSP110WT transcripts synthesized.
C. the frequency of the omission of HSP110 Exon 9 during splicing.
D. the extent of premature translation termination in Exon 10. - 🧠ANSWER
✔✔B. the number of mature HSP110WT transcripts synthesized.
increase deletions, increase E9, decrease WT, decrease tumors
,*this is a double negative (increase suppressor), draw the relation out with
(^v) arrows
Given that CRC mutation is a mismatch in DNA replication and E9
expression is only in cancerous tissue.
A man with a CRC mutation that results in the synthesis of HSP110ΔE9
(has cancer tissue) and a woman that does not carry this mutation in any of
her tissues have a child. What is the percent chance that the child will
inherit the CRC mutation?
A. 0%
B. 25%
C. 50%
D. 100% - 🧠ANSWER ✔✔A. 0%
The CRC mutation is a malfunction mismatch in cancer cells. The
DNA/gene is not the problem but the process of replication is, so cancer is
not inheritable.
COPYRIGHT©JOSHCLAY 2025/2026. YEAR PUBLISHED 2025. COMPANY REGISTRATION NUMBER: 619652435. TERMS OF USE. PRIVACY
3
STATEMENT. ALL RIGHTS RESERVED
, Plus, E9 is only expressed in cancerous/damaged tissue, not in gametes!
(cancer is mostly not inherited but result from damage of the DNA).
*Tricky wording coz mutation=/=genes. Mutation in this case refers to the
mismatch, not a DNA gene mutation! Cancer is not inherited but having
certain genes makes u more susceptible.
Which nucleotide pairing(s) would be recognized by the MMR system
during DNA replication?
I. dTMP and dCMP
II. dGMP and dAMP
III. dAMP and dTMP
A. I only
B. III only
C. I and II only
