1|Page
CMN 548 MODULE 5 PSYCHOPHARMACOLOGY EXAM LATEST 2026
ACTUAL EXAM WITH COMPLETE QUESTIONS AND CORRECT
DETAILED ANSWERS (100% VERIFIED ANSWERS) |ALREADY
GRADED A+| ||PROFESSOR VERIFIED|| ||BRANDNEW!!!||
Why does clozapine (Clozaril, DSA antipsychotic) have a lower
risk of tardive dyskinesia? - ANSWER-It does not result in the
increased sensitivity of striatal D2 receptors, which is associated
with typical neuroleptics and has been theorized to result in TD.
What is the mechanism of action of the two medications approved
for treatment of Tardive Dyskinesia? - ANSWER-VMAT2 inhibitors
- Can be given in conjunction with antipsychotics
What medication is contraindicaated in the treatment of
antipsychotic induced hypotension? - ANSWER-Epinephrine
- due to beta stimulation it worsens hypotension
What is the only dopamine serotonin antagonist (DSA) that is
more effective than other antipsychotics at improving overall
symptoms? - ANSWER-Clozapine (Clozaril)
,2|Page
- This is why antipsychotics are typically chosen based on side
effect profile
Olanzapine (Zyprexa, DSA antipsychotic) causes what side
effects in children? - ANSWER-- Somnolence
- Liver enzyme elevation
- Prolactin elevation
- Weight gain
*Due to these effects it should be used only when other
antipsychotics have failed
Olanzipine (Zyprexa, DSA antipsychotic) has what effect of liver
enzymes? - ANSWER-Increases ALT to 3 times the upper limit of
normal in 2% of cases
Which medication in the DSA antipsychotic family has a low
liability for metabolic side effects? - ANSWER-Lurasidone
(Latuda)
- take with food
,3|Page
- potent antagonist at 5-HT2A, D2, and 5-HT7 receptors and a
partial agonist at the 5-HT1A receptor.
- Side effects include sedation, EPS, nausea
Lurasidone (Latuda, DSA antipsychotic) is FDA approved for the
treatment of what? - ANSWER-- Schizophrenia in adults
- Adults with bipolar depression as a monotherapy or adjunct to
lithium or valproate
Which DSA antipsychotic does not cause EPS, but is associated
with significant hematologic toxicity? - ANSWER-Clozapine
(Clozaril)
- Agranulocytosis
- Reversible when drug is stopped
- Propranolol increases risk of agranulocytosis
Clozapine (Clozaril) is indicated for patients with which psychiatric
diagnosis who are treatment resistant or unable to tolerate side
effects? - ANSWER-Schizophrenia
- Clozapine (Clozaril, DSA antipsychotic)
, 4|Page
- Minimal EPS side effects or tardive dyskinesia
The lack of EPS side effects when taking Clozapine (Clozaril,
DSA antipsychotic) is likely attributed to what in the mechanism o
action? - ANSWER-- Low affinity to the D2 receptor
- Fast dissociation from the D2 receptor
- Looser association to D2 receptor and more readily dissociate in
presence of dopamine
Patients with higher ratios of this metabolite to the parent
compound may have better clinical outcomes to closapine
(Clozaril, DSA antipsychotic)? - ANSWER-N-desmethylclozapine
- has M1 agonist activity
What is the only antipsychotic indicated for suicidal behavior in
schizophrenia and schizoaffective isorder? - ANSWER-Clozapine
(Cloarzil, DSA antipsychotic)
What is the lab value for agranulocytosis? - ANSWER-ANC < 500
cells
CMN 548 MODULE 5 PSYCHOPHARMACOLOGY EXAM LATEST 2026
ACTUAL EXAM WITH COMPLETE QUESTIONS AND CORRECT
DETAILED ANSWERS (100% VERIFIED ANSWERS) |ALREADY
GRADED A+| ||PROFESSOR VERIFIED|| ||BRANDNEW!!!||
Why does clozapine (Clozaril, DSA antipsychotic) have a lower
risk of tardive dyskinesia? - ANSWER-It does not result in the
increased sensitivity of striatal D2 receptors, which is associated
with typical neuroleptics and has been theorized to result in TD.
What is the mechanism of action of the two medications approved
for treatment of Tardive Dyskinesia? - ANSWER-VMAT2 inhibitors
- Can be given in conjunction with antipsychotics
What medication is contraindicaated in the treatment of
antipsychotic induced hypotension? - ANSWER-Epinephrine
- due to beta stimulation it worsens hypotension
What is the only dopamine serotonin antagonist (DSA) that is
more effective than other antipsychotics at improving overall
symptoms? - ANSWER-Clozapine (Clozaril)
,2|Page
- This is why antipsychotics are typically chosen based on side
effect profile
Olanzapine (Zyprexa, DSA antipsychotic) causes what side
effects in children? - ANSWER-- Somnolence
- Liver enzyme elevation
- Prolactin elevation
- Weight gain
*Due to these effects it should be used only when other
antipsychotics have failed
Olanzipine (Zyprexa, DSA antipsychotic) has what effect of liver
enzymes? - ANSWER-Increases ALT to 3 times the upper limit of
normal in 2% of cases
Which medication in the DSA antipsychotic family has a low
liability for metabolic side effects? - ANSWER-Lurasidone
(Latuda)
- take with food
,3|Page
- potent antagonist at 5-HT2A, D2, and 5-HT7 receptors and a
partial agonist at the 5-HT1A receptor.
- Side effects include sedation, EPS, nausea
Lurasidone (Latuda, DSA antipsychotic) is FDA approved for the
treatment of what? - ANSWER-- Schizophrenia in adults
- Adults with bipolar depression as a monotherapy or adjunct to
lithium or valproate
Which DSA antipsychotic does not cause EPS, but is associated
with significant hematologic toxicity? - ANSWER-Clozapine
(Clozaril)
- Agranulocytosis
- Reversible when drug is stopped
- Propranolol increases risk of agranulocytosis
Clozapine (Clozaril) is indicated for patients with which psychiatric
diagnosis who are treatment resistant or unable to tolerate side
effects? - ANSWER-Schizophrenia
- Clozapine (Clozaril, DSA antipsychotic)
, 4|Page
- Minimal EPS side effects or tardive dyskinesia
The lack of EPS side effects when taking Clozapine (Clozaril,
DSA antipsychotic) is likely attributed to what in the mechanism o
action? - ANSWER-- Low affinity to the D2 receptor
- Fast dissociation from the D2 receptor
- Looser association to D2 receptor and more readily dissociate in
presence of dopamine
Patients with higher ratios of this metabolite to the parent
compound may have better clinical outcomes to closapine
(Clozaril, DSA antipsychotic)? - ANSWER-N-desmethylclozapine
- has M1 agonist activity
What is the only antipsychotic indicated for suicidal behavior in
schizophrenia and schizoaffective isorder? - ANSWER-Clozapine
(Cloarzil, DSA antipsychotic)
What is the lab value for agranulocytosis? - ANSWER-ANC < 500
cells
