MCB 4934 Exam 1 Questions With Complete Solutions
trimethoprim was synthesized in ____
1962
Trimethoprim kills cells (T,F)
false
Trimethoprim is a _____ spectrum antibiotic prescribed to treat
MRSA in combination with antibiotics that inhibit ______
broad, folic acid synthesis
Eukaryotes, including humans, cannot synthesize folate (vitamin
B9). (T,F).
True
Bacteria make their own folate. (T,F)
True
DHF synthesis requires _______ and _____
dihydropterin, PABA
Sulfanilamide mimics _______
PABA
Sulfa-drugs are competitive inhibitors of _______
dihydropteroate synthase
Sulfanilamide (type of inhibitor)
folic acid synthesis
, Gerjard Domagk discovered _____
sulfa drugs
Sulfa drugs were largely unknown until who was treated with
them?
Franklin Roosevelt Jr
Cotrimoxazole
combines sulfa drug with trimethoprim
Synergistic effect: the combined potency of a combination of
drugs is much higher than the ____ of their individual potencies
sum
molecule important in folate acid synthesis in bacteria:
PABA
______ and _____ facilitate the synthsis of PABA
ADC synthase and lyase
Enzyme in trimethoprim:
dihydrofolate reductase
Enzyme in sulfamethoxazole:
dihydropteroate synthase
Enzyme in Abyssomicin C
Aminodeoxychorismate
Metronidazole target
DNA disruptor
trimethoprim was synthesized in ____
1962
Trimethoprim kills cells (T,F)
false
Trimethoprim is a _____ spectrum antibiotic prescribed to treat
MRSA in combination with antibiotics that inhibit ______
broad, folic acid synthesis
Eukaryotes, including humans, cannot synthesize folate (vitamin
B9). (T,F).
True
Bacteria make their own folate. (T,F)
True
DHF synthesis requires _______ and _____
dihydropterin, PABA
Sulfanilamide mimics _______
PABA
Sulfa-drugs are competitive inhibitors of _______
dihydropteroate synthase
Sulfanilamide (type of inhibitor)
folic acid synthesis
, Gerjard Domagk discovered _____
sulfa drugs
Sulfa drugs were largely unknown until who was treated with
them?
Franklin Roosevelt Jr
Cotrimoxazole
combines sulfa drug with trimethoprim
Synergistic effect: the combined potency of a combination of
drugs is much higher than the ____ of their individual potencies
sum
molecule important in folate acid synthesis in bacteria:
PABA
______ and _____ facilitate the synthsis of PABA
ADC synthase and lyase
Enzyme in trimethoprim:
dihydrofolate reductase
Enzyme in sulfamethoxazole:
dihydropteroate synthase
Enzyme in Abyssomicin C
Aminodeoxychorismate
Metronidazole target
DNA disruptor
