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COMSAE 107 – COMLEX Level 1 Prep | 2025/2026 | 300+ Questions with Verified Answers | OMM, GI, Neuro, MSK, Cardio, Endo, Micro

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This document contains over 300 high-yield multiple-choice questions and answers from COMSAE 107, a trusted self-assessment tool for COMLEX-USA Level 1 preparation. Updated for the 2025/2026 exam cycle, this resource is designed for DO students seeking to strengthen their mastery of both basic sciences and osteopathic principles in a clinically integrated format. Structured in a straightforward Q&A format with confirmed correct answers, the material mirrors the question style, complexity, and content balance found in actual COMLEX Level 1 exams. It integrates systems-based knowledge with osteopathic manipulative treatment (OMT), ethics, and clinical decision-making. High-yield systems and concepts include: – OMM/OMT: Chapman points, viscerosomatic reflexes, Fryette’s principles, cranial strains, facilitated segments – Gastrointestinal (GI): IBD, ulcers, hepatobiliary disorders, malabsorption, colorectal cancer, hernias – Neurology: cranial nerves, spinal tracts, myasthenia gravis, Guillain-Barré, neurotransmitter pathways – Cardiology: murmurs, congenital heart disease, MI markers, heart failure, EKG findings – Endocrinology: diabetes, thyroid disorders, adrenal axis, hormone regulation – Musculoskeletal (MSK): fracture types, osteoporosis, autoimmune arthropathies – Microbiology: bacteria, viruses, fungal and parasitic infections, toxins, gram stain, vaccines – Pulmonary, Renal, Reproductive, and Hematology systems – Preventive Medicine & Ethics: patient counseling, vaccination schedules, capacity, consent, screening guidelines Best suited for: – DO students preparing for COMLEX Level 1 – Students using COMSAE assessments for benchmarking – Review during systems blocks or cumulative board prep – Tutors, educators, and study groups needing high-yield board-style Q&A This resource is optimized for last-minute revision, spaced recall, and high-yield board reinforcement, giving students a solid command of COMLEX-tested topics. Keywords: COMSAE 107, COMLEX Level 1, OMM, osteopathic principles, GI pathology, neuroanatomy, MSK disorders, endocrinology, microbiology, viscerosomatic reflexes, Fryette’s principles, cranial strain, ethics, board review, DO exam prep, high-yield COMLEX questions, USMLE comparison, vaccine schedules, medical screening, COMLEX Q&A

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COMPLEX1 Comsae 107 2025/2026
Exam Questions and Verified Answers |
Already Graded A+



DMARD drug for UC/Crohns/RA - 🧠ANSWER ✔✔sulfasalazine


pulmonary effects of CF - 🧠ANSWER ✔✔chronic bronchitis and

bronchiectasis


osteoporosis affects what parts of bone? - 🧠ANSWER ✔✔(spongy and )

trabecular bone mass loss


imipramine - 🧠ANSWER ✔✔TCA




SE: Tri-Cs

,convulsions

coma

cardiotox




antichol effects- confusion in elderly; (acute glaucoma and orthostatic

hypotension- block alpha1)


viscerosomatic - 🧠ANSWER ✔✔visceral disease --> somatic finding


loratidine vs ranitidine - 🧠ANSWER ✔✔loratidine: 2nd gen H1 blocker,

doesnt cross BBB --> less sedating




ranitidine: H2 receptor antagonist (like cimetidine)


cells w RBCs inside - 🧠ANSWER ✔✔entaemoba histolytica


which type of pneumothorax causes tracheal deviation to the contra side? -

🧠ANSWER ✔✔tension


intracerebral hemorrhage adjacent to a lesion that contains a tangle of

numerous tortuous vessels - 🧠ANSWER ✔✔AVM arteriovenous

malformation

,cavernous hemangioma - 🧠ANSWER ✔✔benign tumor of liver, A/W VHL


anti-HepB surface antibody is only present in what pop - 🧠ANSWER

✔✔recovered or immunized




not in chronic or


proctalgia fugax - 🧠ANSWER ✔✔levator ani syndrome


fasciculus is UMN or LMN lesion? - 🧠ANSWER ✔✔LMN


ectopic gastric tissue - 🧠ANSWER ✔✔meckels diverticulum




can also have ectopic pancreatic tissue




remnant of vitelline duct


antibodies in hashimotos attacks - 🧠ANSWER ✔✔thyroid peroxidase or

antithyroglobulin




enlarged non tender thyroid

3
COPYRIGHT©JOSHCLAY 2025/2026. YEAR PUBLISHED 2025. COMPANY REGISTRATION NUMBER: 619652435. TERMS OF USE. PRIVACY
STATEMENT. ALL RIGHTS RESERVED

, 2 factors that influence starling curve - 🧠ANSWER ✔✔x axis- preload

(EDV)

y axis- stroke volume or CO


treatment for fibromyalgia - 🧠ANSWER ✔✔TCA, SNRIs anticonvulsants


what blocks NE reuptake? - 🧠ANSWER ✔✔TCA or SNRIs


possible complication of pagets bone disease - 🧠ANSWER

✔✔osteocarcoma


what does Hct tell you? - 🧠ANSWER ✔✔ratio of volume of RBCs compared

to total blood volume


probenecid - 🧠ANSWER ✔✔inhibits reabsoprtion of uric acid in PCT


- also inhibits secretion of PCN

- can ppt uric acid calculi


2 causes of SCID - 🧠ANSWER ✔✔ADA deficiency


(adenosine deaminase required for degradation of adenosim and

deoxyadenosine

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