Lect 15 - Liver Disease Of The Ruminant
Which side of the body can you find the liver
Right
What are the clinical signs associated with liver disease
Icterus, weight loss, photosensitization, diarrhea, rectal prolapse, neurological signs, ascites,
coaguopathy (end stage)
How do you diagnose liver disease
Serum chemistry - GGT, ALP, AST, ALT
Why is GGT levels elevated in younger animals
High in colostrum
What types of bilirubin increase if the bile busts blocked
Both conjugated and unconjugated bilirubin increase
What species if bile acids useful for diagnosing liver disease
Only useful in horses
What is the giant deer fluke
F manga
What is the biggest concern for f magna
Condemnation of liver
What is the MOA of f magna
, Cysts form in the liver and does not allow escape of eggs hence not found in fecal exams
Diagnosis of liver flukes
Biopsy - find live flukes
Fecal - liver fluke sedimentation
ELISA
What is the treatment for liver flukes
Albendazole
Clorsulon with invermectin
When should you treat liver disease
In the fall
What species of liver fluke should you not kill
F magna
When are liver abscesses common
In cattle fed high grain diets
What bacteria is involved with liver abscesses
F. Necrophorum - leukotoxin (most common)
What is black disease
Infectious necrotic hepatitis
What animals are most commonly affected by black disease
Which side of the body can you find the liver
Right
What are the clinical signs associated with liver disease
Icterus, weight loss, photosensitization, diarrhea, rectal prolapse, neurological signs, ascites,
coaguopathy (end stage)
How do you diagnose liver disease
Serum chemistry - GGT, ALP, AST, ALT
Why is GGT levels elevated in younger animals
High in colostrum
What types of bilirubin increase if the bile busts blocked
Both conjugated and unconjugated bilirubin increase
What species if bile acids useful for diagnosing liver disease
Only useful in horses
What is the giant deer fluke
F manga
What is the biggest concern for f magna
Condemnation of liver
What is the MOA of f magna
, Cysts form in the liver and does not allow escape of eggs hence not found in fecal exams
Diagnosis of liver flukes
Biopsy - find live flukes
Fecal - liver fluke sedimentation
ELISA
What is the treatment for liver flukes
Albendazole
Clorsulon with invermectin
When should you treat liver disease
In the fall
What species of liver fluke should you not kill
F magna
When are liver abscesses common
In cattle fed high grain diets
What bacteria is involved with liver abscesses
F. Necrophorum - leukotoxin (most common)
What is black disease
Infectious necrotic hepatitis
What animals are most commonly affected by black disease
