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NNP 2 Final Exam 2025 | Neonatal Nurse Practitioner Practice Test & Certification Study Guide

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Pass your Neonatal NP (NNP) certification final or board exam. Get the newest 2025 practice test with advanced questions on pathophysiology, pharmacology, and critical care management for high-risk neonates.

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Page 1 of 31


NNP 2 FINAL EXAM NEWEST 2025 ACTUAL EXAM|

COMPLETE 150 QUESTIONS AND CORRECT DETAILED

ANSWERS (VERIFIED ANSWERS) ALREADY GRADED

A+| NNP EXAM REVIEW 2025 (NEW!!)

Phototherapy leads to .....ANSWER..... Movement of Bilirubin

from extravascular space to intravascular space

Bilirubin conjugation (direct bilirubin) .....ANSWER..... Creates a

fat

Term, 5-day old presents with lethargy, hypotonia, and mother

reports he is sleeping through the night. .....ANSWER..... Bilirubin

encephalopathy

Antibodies on infant platelets but not on mom's platelets

.....ANSWER..... Isoimmune thrombocytopenia

Why is a critically ill neonate at increased risk for DIC?

.....ANSWER..... Decreased amounts of antithrombin and protein C

,Page 2 of 31


Important factor in determining the cause of thrombocytopenia in

an infant. .....ANSWER..... Maternal low platelets

Appropriate intervention for an infant with oozing heel sticks,

petechiae, bloody ET secretions, low platelets (76), PT 22 PTT 65

.....ANSWER..... Give FFP **Normal Levels: PT= 10-15, PTT= 30-

55, Fibrinogen= 150-373mg/dL

Most common transfusion reaction in neonates .....ANSWER.....

Volume overload

Cryoprecipitate is used to provide .....ANSWER..... Fibrinogen

Term neonate presents with plethora, jitteriness, and HCT >65%,

what is the appropriate action .....ANSWER..... Partial exchange

transfusion with normal saline **HCT 65 or >= exchange

transfusion whether infant is symptomatic or not

The following symptoms are consistent with what: malaise,

irritability, poor weight gain, dribbling, and malodorous urine

.....ANSWER..... UTI

,Page 3 of 31


Perinatal history consistent with duodenal atresia .....ANSWER.....

Polyhydramnios

Dehydration is a risk associated with omphalocele due to

.....ANSWER..... Evaporative losses

Term infant with cystic fibrosis presents with abdominal distension

and metabolic acidosis, what do you suspect? .....ANSWER.....

Meconium ileus

Term infant comes in for 2 week check up and has not returned to

birth weight, listless, poor skin turgor, and mother reports strictly

breastfeeding. What is your first action? .....ANSWER..... Ask

about breastfeeding techniques and observe her breastfeed

Long-term prognosis with short gut syndrome depends on

.....ANSWER..... Presence of ileocecal valve **ileocecal valve-

sphincter that separates the small & large intestine; prevents

bacteria transfer from large to small bowel

, Page 4 of 31


Full term infant failed to pass meconium & has bilious vomiting;

what will both diagnose and treat meconium plug?

.....ANSWER..... Contrast enema: Contrast pulls water from the

intestinal walls and helps make meconium softer

Microbial gut-brain axis has a .....ANSWER..... Reciprocal

relationship

Radiographic findings consistent with Bells Stage 2

.....ANSWER..... Pneumatosis **Bells Stage 1= symptoms of NEC,

no xray findings **Bells Stage 2= pneumatosis on xray **Bells

Stage 3= pneumoperitoneum, free air, air in portal circulation

Leading factor for developing NEC .....ANSWER..... Prematurity

Definitive diagnosis of NEC with radiographic findings of

.....ANSWER..... Pneumatosis

What event at birth increases pathogenesis for NEC

.....ANSWER..... Asphyxia at birth
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