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AANP Family Nurse Practitioner Exam Study Guide | Practice Questions & Rationalized Answers ( 2025/2026 )

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Boost your confidence and excel on the AANP FNP Exam with this comprehensive study guide packed with high-yield practice questions and clear, rationalized explanations. Designed to mirror real exam concepts, this resource strengthens clinical reasoning, improves test performance, and helps you master essential FNP topics with ease. Perfect for fast, focused exam preparation. AANP prep, FNP study, exam guide, test review, practice questions, clinical rationales, board prep, nurse practitioner, exam success, study notes, NP review, high yield, certification prep, nursing exam, FNP practice

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Uploaded on
November 29, 2025
Number of pages
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Written in
2025/2026
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AANP Family Nurse Practitioner Exam
Questions and Verified Rationalized Answers
100% Guarantee Pass




1. A patient tells the nurse practitioner that she recently started taking
the
supplement St. John's wort after reading about its benefits online.
Which of the following medications, if being actively consumed, must be
immediately stopped?


A. Benadryl
B. Famotidine (Pepcid)
C. Metformnin (Glucophage)
D. Sumatriptan (Imitrex)
Ans>> Sumatriptan (imitrex)


Sumatriptan (Imitrex) (D) is a medication used to treat migraines and belongs to a
drug class known as serotonin agonists. When used in conjunction with St. John's
wort, it may increase the risk of serotonin syndrome, a potentially life-threatening
condition.
2. Which of the following is not a symptom of both major depressive
disorder and post-traumatic stress disorder?


A. Difficulty concentrating

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57

,B. Hypervigilance
C. Insomnia
D. Irritabilty
Ans>> Hypervigilance


In addition to difficulty concentrating, insomnia, and irritability, major depressive
disorder (MDD) may also include symptoms of depressed mood, anhedonia,
weight loss or gain, and low energy. However, hypervigilance (B) is not a
symptom associ- ated with this diagnosis.


3. A patient with type 1 diabetes presents for a follow-up visit. He has
been stable on his medication regimen but is worried because he is
between jobs and will be without health insurance coverage for a few
months. He asks if there are less expensive insulin options to get him
through this time. Which of the following would be good options for this
patient, given his circumstance? Incorrect
A.
Insulin aspart 70/30


B.
Insulin detemir
C.




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57

,Insulin isophane


D.
Insulin degludec
Ans>>: Insulin Isophane


The least expensive insulin type listed in this question is insulin isophane (C)
(neutral protamine Hagedorn insulin). There are also often pharmacy-specific
coupons that can be used on insulin, so helping patients apply for and navigate
these pro- grams can be instrumental in managing their diabetes. Another
inexpensive option is regular insulin.Insulin analogs (glargine, detemir, degludec,
lispro, and aspart) are significantly more expensive than human insulin (isophane,
regular). Insulins modified by manufacturers, especially when sold as brand-name
medications, tend to be more expensive due to this modification. While analogs
offer alternate lengths of action and convenience, there is no well-documented
clinical evidence that patient outcomes are improved with differing brands.
Therefore, maintaining a patient's blood glucose level through outcome-focused
treatment is more valuable than a process-focused plan based on medication.


4. A 40-year-old woman with type 2 diabetes presents to the clinic with
con- cerns of spiking blood sugar between lunch and dinner. She states
she is on a rapid-acting insulin sliding scale and long-acting insulin.
Which change should be implemented to help prevent or curb this
glycemic spike?


A.
Add a dose of mealtime insulin aspart (Novolog) at lunch



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57

, B.
Add insulin detemir (Levemir) at night


C.
Increase her insulin glargine (Lantus)


D.
Prescribe a dose of neutral protamine Hagedorn insulin with dinner
Ans>> Add a dose of mealtime insulin aspart (Novolog) at lunch


Insulin aspart (Novolog) (A) is a rapid acting insulin that is commonly dosed with
meals and as a sliding scale regimen based on a patient's glucose prior to eating
(preprandial). It is the appropriate insulin to add as a mealtime dose when
patients experience blood glucose spikes between meals because of its short-
acting proper-




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