Terms in this set (108)
Administration
- Administer orally or rectally.
Client Teaching
- Advise clients to assess over-the-counter medications for
acetaminophen and monitor the daily amount. 3900mg/day is the
maximum amount.
Acetaminophen (Tylenol):
- Advise clients to avoid alcohol.
Administration and Client Teaching
- Advise clients to only consume 2000mg/day if they drink more than
3 alcoholic beverages per day.
Category: Cyclooxygenase Inhibitors (Drugs that Lack Anti-
inflammatory Actions)
Primary Function: Acetaminophen reduces prostaglandin synthesis
Acetaminophen (Tylenol): in the CNS to reduce pain and fever.
Category, Primary Function, Unique Features: Acetaminophen is used more than any other
Unique Features analgesic.
, - Dosing varies based on the condition, severity, and client response.
- Check drug dosing guidelines for individualized dosing.
- Oral (tablet or solution) or rectal dosing.
- Do not use in clients with liver impairment due to the risk for
hepatotoxicity.
- Monitor daily dose of acetaminophen as many other products (cold
and flu medications, other pain medication combination drugs, etc.)
also contain acetaminophen. The maximum daily dose is
Acetaminophen (Tylenol): Dosing 3900mg/day.
- Administering acetylcysteine (Mucomyst) for overdose can reduce
liver injury.
- Alcohol consumption
Acetaminophen (Tylenol): Drug - Warfarin
Interactions - Vaccines (blunt response)
- Pain Relief: Acetaminophen is used when mild pain relief is
Acetaminophen (Tylenol): needed across a range of indications.
Indications and Therapeutic Uses - Fever: Acetaminophen can be used to reduce fever.
Liver Function Tests (LFTs)
Acetaminophen (Tylenol): Labs to Regular liver function tests may be required for certain clients due to
Monitor the potential for liver injury.
, Acetaminophen reduces prostaglandin synthesis in the CNS to
reduce pain and fever. While acetaminophen is mostly transformed
into safe metabolites after metabolism, liver enzymes convert a
small part into a harmful substance. Normally, this dangerous
byproduct is quickly neutralized, but in cases of overdose, it
Acetaminophen (Tylenol): MOA
accumulates and can severely damage the liver due to the depletion
of protective glutathione.
Precautions
- Monitor for hepatic dysfunction.
- Caution with clients who consume three or more alcoholic drinks
daily.
- Administering acetylcysteine (Mucomyst) for overdose can reduce
liver injury.
Acetaminophen (Tylenol): Contraindications
- Contraindicated in clients with hepatic impairment.
Precautions, Contraindications,
- Contraindicated in clients who consume high amounts of alcohol.
Black Box Warning
Black Box Warning
- Serious liver injury can result from acetaminophen.
- Hypertension
- Hepatotoxicity
- Rash: Stevens-Johnson Syndrome (SJS), acute generalized
Acetaminophen (Tylenol): Side exanthematous pustulosis (AGEP), or toxic epidermal necrolysis
Effects and Adverse Reactions (TEN)
, - Occurs for less than three months and is often precipitated by
trauma, acute medical conditions, surgery, or treatment.
- Subacute pain has a duration of 1-3 months.
- Categorized as referred pain, acute somatic pain, or acute visceral
pain.
Acute Pain - Rated by severity.
- The focus is on immediate relief and prevention of transition to
chronic pain, utilizing a variety of drugs.
- Short-acting opioids should be used exclusively as the treatment of
acute pain in opioid-naive clients (as opposed to opioid-tolerant
clients).
- Titration to optimal therapeutic effects is faster, safer, and easier
with immediate-release opioids (as opposed to extended-release
Acute Pain and Opioids opioids).
- Unintentional overdose may be more likely when opioid therapy
begins with long-acting opioids in opioid-naive clients.
- Metabolized in the liver, resulting in a slower degradation and
extended duration of action.
- Amide anesthetics are less likely to induce allergic reactions,
making them a preferred choice for clients in most situations,
including clients with a history of allergies or who require longer
Amide anesthetics (lidocaine procedures.
(Xylocaine)) - Amides are generally considered safer for use in clients with
certain systemic conditions.
Administration
- Administer orally or rectally.
Client Teaching
- Advise clients to assess over-the-counter medications for
acetaminophen and monitor the daily amount. 3900mg/day is the
maximum amount.
Acetaminophen (Tylenol):
- Advise clients to avoid alcohol.
Administration and Client Teaching
- Advise clients to only consume 2000mg/day if they drink more than
3 alcoholic beverages per day.
Category: Cyclooxygenase Inhibitors (Drugs that Lack Anti-
inflammatory Actions)
Primary Function: Acetaminophen reduces prostaglandin synthesis
Acetaminophen (Tylenol): in the CNS to reduce pain and fever.
Category, Primary Function, Unique Features: Acetaminophen is used more than any other
Unique Features analgesic.
, - Dosing varies based on the condition, severity, and client response.
- Check drug dosing guidelines for individualized dosing.
- Oral (tablet or solution) or rectal dosing.
- Do not use in clients with liver impairment due to the risk for
hepatotoxicity.
- Monitor daily dose of acetaminophen as many other products (cold
and flu medications, other pain medication combination drugs, etc.)
also contain acetaminophen. The maximum daily dose is
Acetaminophen (Tylenol): Dosing 3900mg/day.
- Administering acetylcysteine (Mucomyst) for overdose can reduce
liver injury.
- Alcohol consumption
Acetaminophen (Tylenol): Drug - Warfarin
Interactions - Vaccines (blunt response)
- Pain Relief: Acetaminophen is used when mild pain relief is
Acetaminophen (Tylenol): needed across a range of indications.
Indications and Therapeutic Uses - Fever: Acetaminophen can be used to reduce fever.
Liver Function Tests (LFTs)
Acetaminophen (Tylenol): Labs to Regular liver function tests may be required for certain clients due to
Monitor the potential for liver injury.
, Acetaminophen reduces prostaglandin synthesis in the CNS to
reduce pain and fever. While acetaminophen is mostly transformed
into safe metabolites after metabolism, liver enzymes convert a
small part into a harmful substance. Normally, this dangerous
byproduct is quickly neutralized, but in cases of overdose, it
Acetaminophen (Tylenol): MOA
accumulates and can severely damage the liver due to the depletion
of protective glutathione.
Precautions
- Monitor for hepatic dysfunction.
- Caution with clients who consume three or more alcoholic drinks
daily.
- Administering acetylcysteine (Mucomyst) for overdose can reduce
liver injury.
Acetaminophen (Tylenol): Contraindications
- Contraindicated in clients with hepatic impairment.
Precautions, Contraindications,
- Contraindicated in clients who consume high amounts of alcohol.
Black Box Warning
Black Box Warning
- Serious liver injury can result from acetaminophen.
- Hypertension
- Hepatotoxicity
- Rash: Stevens-Johnson Syndrome (SJS), acute generalized
Acetaminophen (Tylenol): Side exanthematous pustulosis (AGEP), or toxic epidermal necrolysis
Effects and Adverse Reactions (TEN)
, - Occurs for less than three months and is often precipitated by
trauma, acute medical conditions, surgery, or treatment.
- Subacute pain has a duration of 1-3 months.
- Categorized as referred pain, acute somatic pain, or acute visceral
pain.
Acute Pain - Rated by severity.
- The focus is on immediate relief and prevention of transition to
chronic pain, utilizing a variety of drugs.
- Short-acting opioids should be used exclusively as the treatment of
acute pain in opioid-naive clients (as opposed to opioid-tolerant
clients).
- Titration to optimal therapeutic effects is faster, safer, and easier
with immediate-release opioids (as opposed to extended-release
Acute Pain and Opioids opioids).
- Unintentional overdose may be more likely when opioid therapy
begins with long-acting opioids in opioid-naive clients.
- Metabolized in the liver, resulting in a slower degradation and
extended duration of action.
- Amide anesthetics are less likely to induce allergic reactions,
making them a preferred choice for clients in most situations,
including clients with a history of allergies or who require longer
Amide anesthetics (lidocaine procedures.
(Xylocaine)) - Amides are generally considered safer for use in clients with
certain systemic conditions.
