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1. Epiphysis End of a long bone
2. Diaphysis shaft of long bone
3. Periosteum (outside)
-Contains fibrous & osteogenic layers
4. Endosteum (inside)
-Lining of medullary cavity
-Contain osteogenic cells
5. articular cartilage Covers joint to reduce friction
6. medullary cavity Site of bone marrow production
7. ephiphyseal
plate/line
8. Spongy (trabecu- Many spaces for vessels and marrow
lar) bone
9. Compact bone Very few spaces for vessels and marrow
10. Chondrocytes cartilage cells
11. Osteon contains central canal, Volkmann's canals, lacuna, canaliculi, lamella layers
12. Collagen Collagen is a connective tissue that consists of chondrocytes (cells) that secrete
collagen into a solid
matrix, but not mineralized matrix
13. Osseous tissue consists of osteocytes (cells) that secrete
collagen in to a mineralized (hydroxyapatite) matrix
14. Osteogenic stem cell whose divisions produce osteoblasts
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, BIO 161- Penn State Exam 4
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15. Osteoblasts immature bone cells that secretes organic components of matrix
16. Osteocytes mature bone cell that maintains the bone matrix
17. Osteoclast multinucleate cell that secretes acids and enzymes to dissolve bone matrix
18. Force and Force hormones and nutrition affect turnover (remodeling) of the matrix
Lines
19. intramembra- Bone is formed from membranes
nous ossification •Cranial bones
•Clavicles
20. Endochondral os- •Bone is formed from cartilage
sification •All other bones
21. Interstitial Growth at epiphyseal plates is called interstitial growth. It leads to increase bone
growth length.
22. appositional growth at the surface that allow our bones to become thicker (or maintain thickness
growth but increase in diameter)
23. Chondrocyte regulated by several hormones including growth hormone (GH)
24. Epiphyseal plate located between epiphysis and diaphysis.
(layers) Resting-zone = toward the epiphysis, site of stem cells
Proliferating zone = massive chondrocyte division and
cartilage matrix production
Hypertrophic zone = chondrocytes enlarge and create large spaces in the matrix
and eventually die
Calcification zone = osteoblasts/osteoclasts inside medullary cavity replace carti-
lage matrix with osseous matrix
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