PHA 317: Pharmaceutics I Exam 2
Questions and Answers 100%
Pass
TRUE OR FALSE: The lower the pKa value for an acid, the greater the
hydronium ion concentration it would produce on being added to water. -
CORRECT ANSWER-True
TRUE OR FALSE: Stronger bases, such as guanethidine (pKa >11) are ionized
throughout the GI tract and tend to be well absorbed throughout the GI tract. -
CORRECT ANSWER-False - strong bases are ionized in the GI tract and
therefore poorly absorbed throughout the GI tract
What is the pH of a buffer containing 0.1-M acetic acid (pKa 4.8) and 0.08 M
sodium acetate? - CORRECT ANSWER-4.7
unionized molecules are soluble where? - CORRECT ANSWER-lipid bilayer - can
cross blood-brain barrier
, TRUE OR FALSE: most weak bases are poorly absorbed in the stomach, because
they are present largely in the ionized form at pH 1-2. - CORRECT ANSWER-
True
TRUE OR FALSE: weakly basic drugs with a pKa of less than 4, such as dapsone,
diazepam, and chlordiazepoxide, are essentially un-ionized throught the GI tract. -
CORRECT ANSWER-True
TRUE OR FALSE: The Beer-Lambert Law is the basis for deriving quantitative
information from an absorption spectrum. - CORRECT ANSWER-True
TRUE OR FALSE: in regards to Beer-Lambert law, the constant k, is called molar
absorption coefficient if unit concentration (c) is mole/liter. - CORRECT
ANSWER-True
TRUE OR FALSE: in regards to Beer-Lambert law, the constant k, is called
specific absorption coefficient if unit concentration (c) is gram/liter. - CORRECT
ANSWER-True
TRUE OR FALSE: the ratio of absorbance of DNA at 260nm to 280nm is 1.8 and
2 for RNA - CORRECT ANSWER-True
TRUE OR FALSE: Tyrosine and Tryptophan are most prominent amino acids
capable of producing fluorescence when exposed to radiation of wavelength
190nm. - CORRECT ANSWER-False - proteins are absormed at 280nm
Questions and Answers 100%
Pass
TRUE OR FALSE: The lower the pKa value for an acid, the greater the
hydronium ion concentration it would produce on being added to water. -
CORRECT ANSWER-True
TRUE OR FALSE: Stronger bases, such as guanethidine (pKa >11) are ionized
throughout the GI tract and tend to be well absorbed throughout the GI tract. -
CORRECT ANSWER-False - strong bases are ionized in the GI tract and
therefore poorly absorbed throughout the GI tract
What is the pH of a buffer containing 0.1-M acetic acid (pKa 4.8) and 0.08 M
sodium acetate? - CORRECT ANSWER-4.7
unionized molecules are soluble where? - CORRECT ANSWER-lipid bilayer - can
cross blood-brain barrier
, TRUE OR FALSE: most weak bases are poorly absorbed in the stomach, because
they are present largely in the ionized form at pH 1-2. - CORRECT ANSWER-
True
TRUE OR FALSE: weakly basic drugs with a pKa of less than 4, such as dapsone,
diazepam, and chlordiazepoxide, are essentially un-ionized throught the GI tract. -
CORRECT ANSWER-True
TRUE OR FALSE: The Beer-Lambert Law is the basis for deriving quantitative
information from an absorption spectrum. - CORRECT ANSWER-True
TRUE OR FALSE: in regards to Beer-Lambert law, the constant k, is called molar
absorption coefficient if unit concentration (c) is mole/liter. - CORRECT
ANSWER-True
TRUE OR FALSE: in regards to Beer-Lambert law, the constant k, is called
specific absorption coefficient if unit concentration (c) is gram/liter. - CORRECT
ANSWER-True
TRUE OR FALSE: the ratio of absorbance of DNA at 260nm to 280nm is 1.8 and
2 for RNA - CORRECT ANSWER-True
TRUE OR FALSE: Tyrosine and Tryptophan are most prominent amino acids
capable of producing fluorescence when exposed to radiation of wavelength
190nm. - CORRECT ANSWER-False - proteins are absormed at 280nm
