CORRECT WELL DETAILED ANSWERS|LATEST
What are two cells that use receptors to distinguish between self and non-self cells? -
ANSWER -Macrophages
-NK Cells
C3b is a ligand for - ANSWER Macrophage CR1
CR3 & CR4 - ANSWER Recognize iC3b & other ligands including LPS
Lectins - ANSWER Carbohydrates-binding proteins
ex: Mannose & glucose receptors
Scavenger Receptors - ANSWER Prefer molecules that are negatively charged like
nucleic acids, LPS.
Phagocytic Receptors - ANSWER Bind directly to microbial surface components
What do surface receptors promote? - ANSWER Phagocytosis
PRR's bind to - ANSWER PAMPs on pathogens
Receptors that detect microbial products signal what? - ANSWER -Macrophage
activation
1
, -Cytokine Secretion
Toll-Like Receptors (TLR) - ANSWER -10 receptors
-Has specificities for several microbial products
TLR-4 - ANSWER -Senses LPS
-Found on macrophages
What can LPS cause? - ANSWER Septic Shock
What is LPS known for being? - ANSWER Endotoxin
What is local accumulation of fluid accompanied by? - ANSWER Swelling, redness,
heat, & pain
What does increased dilation cause? - ANSWER Reduced blood flow
Complement receptors 3&4 (Mac-1, CD11b, CD8) target what? - ANSWER Bacteria &
Fungi
CD14 binds to what? - ANSWER -LPS
-Peptidoglycan
What does IL-8 (CXCL-8) do? - ANSWER Attracts leukocytes (neutrophils) to the site of
infection/damage
What are your proinflammatory cytokines? - ANSWER -IL-1Beta
-IL-6
2
What are two cells that use receptors to distinguish between self and non-self cells? -
ANSWER -Macrophages
-NK Cells
C3b is a ligand for - ANSWER Macrophage CR1
CR3 & CR4 - ANSWER Recognize iC3b & other ligands including LPS
Lectins - ANSWER Carbohydrates-binding proteins
ex: Mannose & glucose receptors
Scavenger Receptors - ANSWER Prefer molecules that are negatively charged like
nucleic acids, LPS.
Phagocytic Receptors - ANSWER Bind directly to microbial surface components
What do surface receptors promote? - ANSWER Phagocytosis
PRR's bind to - ANSWER PAMPs on pathogens
Receptors that detect microbial products signal what? - ANSWER -Macrophage
activation
1
, -Cytokine Secretion
Toll-Like Receptors (TLR) - ANSWER -10 receptors
-Has specificities for several microbial products
TLR-4 - ANSWER -Senses LPS
-Found on macrophages
What can LPS cause? - ANSWER Septic Shock
What is LPS known for being? - ANSWER Endotoxin
What is local accumulation of fluid accompanied by? - ANSWER Swelling, redness,
heat, & pain
What does increased dilation cause? - ANSWER Reduced blood flow
Complement receptors 3&4 (Mac-1, CD11b, CD8) target what? - ANSWER Bacteria &
Fungi
CD14 binds to what? - ANSWER -LPS
-Peptidoglycan
What does IL-8 (CXCL-8) do? - ANSWER Attracts leukocytes (neutrophils) to the site of
infection/damage
What are your proinflammatory cytokines? - ANSWER -IL-1Beta
-IL-6
2
