Science Medicine Nephrology
NR565 week 3
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Kidney TTK 11 Kidney Failure URINARY DRY ERASE BOARD Chapte
21 terms 59 terms 66 terms 24 terms
dc205889 Preview aavvinti21 Preview arviannajackson Preview em
Thiazide
Order HTN medications are typically
ACEIs
prescribed for non blacks
ARBS
Order HTN medications are typically thiazide
prescribed blacks CCB
Preferred antihypertensive drugs in ACEIs, ARBs, CCBs, and diuretics (in low doses).
patients with diabetes are
Thiazides
Furosemide
What drug classes should be used with β Blockers
caution for htn with ppl with diabetes?
Thiazides and furosemide promote hyperglycemia, and β blockers suppress
glycogenolysis and can mask signs of hypoglycemia.
why are ACEIs and ARBS used in diabetic ACEIs and ARBs can slow the progression of renal damage and reduce albuminuria.
nephropathy?
Best approach or drug to use during When drug therapy is initiated during pregnancy, methyldopa and labetalol are the
pregnancy or someone wishing to become traditional agents of choice.
pregnant
What drug classes for htn are ACEIs, ARBs, and DRIs are contraindicated owing to their potential for harm (fetal
contraindicated for pregnacy? growth delay, congenital malformations, neonatal renal failure, neonatal death).
How is hypertension defined in severe htn SBP >160 or DBP >110 (treatment)
pregnancy? mild htn SBP 140 to 159 or DBP 90 to 109 (no treatment)
What category are ACEIs in pregnancy (A- Category C during first trimester
D) Category D during second and third trimester
What is the therapeutic action of a Thiazide increase renal excretion of sodium, chloride, potassium and water
diuretic?
reduce levels of angiotensin II through inhibition of ACE and increasing levels of
What is the therapeutic action of ACEIs?
bradykinin (through inhibition of kinase II)
, -Blocks angiotensin II receptors on blood vessels, in the heart, and in the adrenals
What is the therapeutic action of ARBs?
-Increases renal excretion of sodium and water
What is the therapeutic action of CCBs? dihydropyridines act primarily on arterioles
Diuretics are medications that act on the kidneys to increase production of urine,
therefore increasing elimination of water from the body.
Tell me about diuretics
All diuretics decrease blood volume, venous pressure, and preload.
Prevent Na+ reabsorption in the distal convoluted tubule of the kidney by blocking
What is the function of thiazide diuretics?
the thiazide sensitive Na+/Cl- symporter
PRIL --
captopril
What ending do ACEI's share?
enalapril
lisinopril
What is a major side of effect of ACEI's? As a result of blocking ACE, bradykinins form and cause the dry cough but can later
PRIL!!!!! lead to life-threatening angioedema.
acute myocardial infarction (MI) in order to increase the perfusion of the heart to
What other illness can ACEIs/ARBs be used prevent further ischemic damage.
for?
heart failure
SARTAN
candesartan
ARBs share what ending?
valsartan
losartan
What are two common adverse effects of hypotension
ACEI's and ARBs? hyperkalemia
What do ACEIs increase that can cause bradykinin levels
cough and angioedema?
PINE
nifedipine
What endings do CCBs share?
nicardipine
(dihydropyridines)
amlodipine
nimodipine
What are two examples of non- verpamil
dihydropyridines CCBs diltiazem
Creates vasodilation by blocking voltage- Dihydropyridines CCB
gated calcium channels in both cardiac
smooth muscles as well as in blood vessels.
They preferentially exert their effects on
arterial smooth muscle, and nifedipine is
the prototype of this class.
What drug class for HTN should be ACE inhibitors should be avoided by African American/Black and should take
avoided in AAs thiazides and/or CCBs.
Rosuvastatin reaches abnormally high levels in people of Asian heritage.
What statin medication causes issues for
At usual therapeutic doses, rosuvastatin levels in these people are about twice those
Asians?
in Whites. Accordingly, if rosuvastatin is used by Asians, dosage should be reduced
due to lack of CYP3A4
NR565 week 3
Save
Students also studied
Kidney TTK 11 Kidney Failure URINARY DRY ERASE BOARD Chapte
21 terms 59 terms 66 terms 24 terms
dc205889 Preview aavvinti21 Preview arviannajackson Preview em
Thiazide
Order HTN medications are typically
ACEIs
prescribed for non blacks
ARBS
Order HTN medications are typically thiazide
prescribed blacks CCB
Preferred antihypertensive drugs in ACEIs, ARBs, CCBs, and diuretics (in low doses).
patients with diabetes are
Thiazides
Furosemide
What drug classes should be used with β Blockers
caution for htn with ppl with diabetes?
Thiazides and furosemide promote hyperglycemia, and β blockers suppress
glycogenolysis and can mask signs of hypoglycemia.
why are ACEIs and ARBS used in diabetic ACEIs and ARBs can slow the progression of renal damage and reduce albuminuria.
nephropathy?
Best approach or drug to use during When drug therapy is initiated during pregnancy, methyldopa and labetalol are the
pregnancy or someone wishing to become traditional agents of choice.
pregnant
What drug classes for htn are ACEIs, ARBs, and DRIs are contraindicated owing to their potential for harm (fetal
contraindicated for pregnacy? growth delay, congenital malformations, neonatal renal failure, neonatal death).
How is hypertension defined in severe htn SBP >160 or DBP >110 (treatment)
pregnancy? mild htn SBP 140 to 159 or DBP 90 to 109 (no treatment)
What category are ACEIs in pregnancy (A- Category C during first trimester
D) Category D during second and third trimester
What is the therapeutic action of a Thiazide increase renal excretion of sodium, chloride, potassium and water
diuretic?
reduce levels of angiotensin II through inhibition of ACE and increasing levels of
What is the therapeutic action of ACEIs?
bradykinin (through inhibition of kinase II)
, -Blocks angiotensin II receptors on blood vessels, in the heart, and in the adrenals
What is the therapeutic action of ARBs?
-Increases renal excretion of sodium and water
What is the therapeutic action of CCBs? dihydropyridines act primarily on arterioles
Diuretics are medications that act on the kidneys to increase production of urine,
therefore increasing elimination of water from the body.
Tell me about diuretics
All diuretics decrease blood volume, venous pressure, and preload.
Prevent Na+ reabsorption in the distal convoluted tubule of the kidney by blocking
What is the function of thiazide diuretics?
the thiazide sensitive Na+/Cl- symporter
PRIL --
captopril
What ending do ACEI's share?
enalapril
lisinopril
What is a major side of effect of ACEI's? As a result of blocking ACE, bradykinins form and cause the dry cough but can later
PRIL!!!!! lead to life-threatening angioedema.
acute myocardial infarction (MI) in order to increase the perfusion of the heart to
What other illness can ACEIs/ARBs be used prevent further ischemic damage.
for?
heart failure
SARTAN
candesartan
ARBs share what ending?
valsartan
losartan
What are two common adverse effects of hypotension
ACEI's and ARBs? hyperkalemia
What do ACEIs increase that can cause bradykinin levels
cough and angioedema?
PINE
nifedipine
What endings do CCBs share?
nicardipine
(dihydropyridines)
amlodipine
nimodipine
What are two examples of non- verpamil
dihydropyridines CCBs diltiazem
Creates vasodilation by blocking voltage- Dihydropyridines CCB
gated calcium channels in both cardiac
smooth muscles as well as in blood vessels.
They preferentially exert their effects on
arterial smooth muscle, and nifedipine is
the prototype of this class.
What drug class for HTN should be ACE inhibitors should be avoided by African American/Black and should take
avoided in AAs thiazides and/or CCBs.
Rosuvastatin reaches abnormally high levels in people of Asian heritage.
What statin medication causes issues for
At usual therapeutic doses, rosuvastatin levels in these people are about twice those
Asians?
in Whites. Accordingly, if rosuvastatin is used by Asians, dosage should be reduced
due to lack of CYP3A4
