CMN 548 MODULE 5 PSYCHOPHARMACOLOGY
EXAM NEWEST 2026 ACTUAL EXAM
QUESTIONS AND CORRECT DETAILED
ANSWERS (VERIFIED ANSWERS) ALL
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Why are MAOIs effective? - ✔✔✔ Correct Answer > Thought that MAOIs
alleviate depression by direct inhibition of MAO and an increase
in catecholamines available within the synapse.
- Increased MAO-A binding is implicated in depression
What is the recommended dosing regimen for patients taking
Vortioxetine (Trintellix) for MDD? - ✔✔✔ Correct Answer > - Starting
dose 10 mg/day ages 18-65
- Target dose 5-20 mg/day
- Increase in at least 2 week intervals
What genitourinary symptoms are caused by Trazodone? - ✔✔✔
Correct Answer > - Priapism
- Alpha adrenergic receptor antagonists induce priapism by
inhibiting sympathetically controlled detumescence
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- Likely in first 28 days
- Urologic emergency lasting more than 1 hour
- Treatment with surgical procedure
Which patient populations are at highest risk for tardive
dyskinesia? - ✔✔✔ Correct Answer > - Older women
- Patients with affective disorders
- 10-20% incidence in treatment >1 year
How often should patients receiving dopamine blockers be
evaluated for tardive dyskinesia? - ✔✔✔ Correct Answer > Every 6
months
- Can evaluate severity using the Abnormal Involuntary
Movements Scale (AIMS)
Why does clozapine (Clozaril, DSA antipsychotic) have a lower
risk of tardive dyskinesia? - ✔✔✔ Correct Answer > It does not result in
the increased sensitivity of striatal D2 receptors, which is
associated with typical neuroleptics and has been theorized to
result in TD.
What is the mechanism of action of the two medications
approved for treatment of Tardive Dyskinesia? - ✔✔✔ Correct Answer >
VMAT2 inhibitors
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- Can be given in conjunction with antipsychotics
What is tranlcypromine (Parnate) FDA approved for and what are
its off label uses? - ✔✔✔ Correct Answer > - FDA approved: Major
depressive episodes
- Off Label: epressive disorders, panic disorder, social anxiety
disorder, and PTSD
What pregnancy class is Selegeline (Eldepryl, MAOI)? - ✔✔✔ Correct
Answer > - Category C
- Excreted into breast milk, discussion point of continuance
How does tyramine interact with MAOIs and what condition can
result from ingestion of tyramine rich foods? - ✔✔✔ Correct Answer >
Nonselective and irreversible MAOIs, when combined with food
rich in tyramine, can cause increased release of catecholamines,
resulting in a hypertensive crisis characterized by an occipital
headache, palpitations, nausea, vomiting, diaphoresis, and
tachycardia.
Hypertensive crisis can occur when MAOIs are given with... - ✔✔✔
Correct Answer > Any medication that increases adrenergic
stimulation by a mechanism other than MAO inhibition
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What are the symptoms of MAOI withdrawal and when do they
occur? - ✔✔✔ Correct Answer > - Dilated pupils, fever, diaphoresis,
drowsiness, agitation, headache, hallucinations, trismus,
opisthotonos, seizures, coma, fever, tachycardia, hypertension,
hypotension, respiratory depression/failure, shock, and death
- Absent or minimal during the initial 12-hour period following
ingestion and may develop slowly, reaching a maximum in 24 to
48 hours, may persist 8-14 days
What are the characteristics of withdrawal syndrome with
MAOIs? - ✔✔✔ Correct Answer > - Increased arousal
- Mood disturbance
- Psychosis
- Convulsions
24-72 hours after discontinuation
Trazodone is a potent antagonist of which receptor? - ✔✔✔ Correct
Answer > - 5HT2A
- peripheral alpha adrenergic receptors (cause for orthostatic
hypotension, dizziness, dry mouth, priapism)
What was the effective dosing regimen of Trazodone for
treatment of childhood disruptive behaviors in clinical study? -
✔✔✔ Correct Answer > Thrice-daily dosing of trazodone at an average