PHA 317 Final UPDATED Questions and
CORRECT Answers
Cup and Bob type of viscometer may be used for gels and pastes - CORRECT ANSWER -
True
For nitroglycerine (NTG), it is important to counsel patient not to remove tablets from packaging
until they actually use the tablets. This is due to what characteristic of NTG? - CORRECT
ANSWER - NTG is susceptible to loss by sublimation at room temperature
A statement such as "not less than 110.0 percent" in the official compendia of the U.S.
Pharmacopeia and National Formulary may mean 110.1 or 110.2 percent - CORRECT
ANSWER - True
The most stable polymorph is always used for better clinical outcomes - CORRECT
ANSWER - False
Solving (567^14)1/7 is best stated as what - CORRECT ANSWER - anti log [(1/7) x 14 x
log567]
Which of the following does NOT increase aqueous solubility - CORRECT ANSWER -
Increasing the length of a straight chain organic compounds
Increasing which of the following will increase permeability of a molecule across a biological
membrane - CORRECT ANSWER - Diffusivity of the molecule
100mL of water was added to a 200mL solution. When the total volume was measured, it was
found only 298mL even if there is no loss of material during mixing. Is this a real solution -
CORRECT ANSWER - Yes
Which of the following statements is correct regarding diarrhea - CORRECT ANSWER -
The diarrhea causing microorganisms impair either the cryptic or villus cells activity or activity
,of both which results into more production of Cl- ions or less absorption of nutrients and Na+
ions
1g of a drug s soluble in 10.50 L of water. Which one of the following correctly define its
solubility as per USP definition - CORRECT ANSWER - Practically insoluble
Blood plasma normally shows viscosity only, while whole blood is both viscous and elastic -
CORRECT ANSWER - True
Thixotropy is a comparatively fast recovery of a material of consistency lost due to shearing
stress - CORRECT ANSWER - False
A matter that exhibits plastic flow, below its yield value would behave as - CORRECT
ANSWER - Elastic flow
The arrhenius equation of rheology expresses the relationship between - CORRECT
ANSWER - Viscosity and temperature
Ostwald viscometer is used for - CORRECT ANSWER - liquids that flow relatively easily
Pseudoplatic flow has a yield value - CORRECT ANSWER - False
The key factor in the viscoelasticity of blood are - CORRECT ANSWER - both
aggregation and deformability
1 centipoise is equal to - CORRECT ANSWER - 0.01 poise
If the shearing stress is directly proportional to the rate of shear the liquid exhibits a - CORRECT
ANSWER - Newtonian flow
, Which one of the following facts are correct with respect to thixotropy - CORRECT
ANSWER - Exhibited by shear thinning systems, such as pseudoplastic and plastic liquids
Can be defined as an isothermal and comparatively slow recovery, on standing of a material, of a
consistency lost through shearing
Behavior is useful for many pharmaceutical preps (suspensions)
Which one of the following is the most desirable flow characteristic for a dosage form design -
CORRECT ANSWER - Thixotropic flow
Under which situation will the viscosity of oil increase - CORRECT ANSWER - As
temperature decreases
Viscosity of an unknown liquid is 0.580 cp at 25 degrees celsius and the density is 0.858/cm
cubed. What is the kinematic viscosity of the unknown liquid - CORRECT ANSWER -
0.676 centistrokes
Plastic flow is associated with - CORRECT ANSWER - Suspensions
For Newtonian fluids, if the rate of shear is increased two times from its original value while the
viscosity remains constant. What change could you expect in shearing stress of that liquid -
CORRECT ANSWER - Double it's original value
Thixotropy is a special characteristic that is exhibited by shear thinning systems, such as -
CORRECT ANSWER - Plastic and Pseudoplastic
Polymers in a solution generally exhibit plastic flow - CORRECT ANSWER - False
A solution isoosmotic with blood would be isotonic too - CORRECT ANSWER - False
Molarity of a solution does not depend on temperature of the solution - CORRECT
ANSWER - False
CORRECT Answers
Cup and Bob type of viscometer may be used for gels and pastes - CORRECT ANSWER -
True
For nitroglycerine (NTG), it is important to counsel patient not to remove tablets from packaging
until they actually use the tablets. This is due to what characteristic of NTG? - CORRECT
ANSWER - NTG is susceptible to loss by sublimation at room temperature
A statement such as "not less than 110.0 percent" in the official compendia of the U.S.
Pharmacopeia and National Formulary may mean 110.1 or 110.2 percent - CORRECT
ANSWER - True
The most stable polymorph is always used for better clinical outcomes - CORRECT
ANSWER - False
Solving (567^14)1/7 is best stated as what - CORRECT ANSWER - anti log [(1/7) x 14 x
log567]
Which of the following does NOT increase aqueous solubility - CORRECT ANSWER -
Increasing the length of a straight chain organic compounds
Increasing which of the following will increase permeability of a molecule across a biological
membrane - CORRECT ANSWER - Diffusivity of the molecule
100mL of water was added to a 200mL solution. When the total volume was measured, it was
found only 298mL even if there is no loss of material during mixing. Is this a real solution -
CORRECT ANSWER - Yes
Which of the following statements is correct regarding diarrhea - CORRECT ANSWER -
The diarrhea causing microorganisms impair either the cryptic or villus cells activity or activity
,of both which results into more production of Cl- ions or less absorption of nutrients and Na+
ions
1g of a drug s soluble in 10.50 L of water. Which one of the following correctly define its
solubility as per USP definition - CORRECT ANSWER - Practically insoluble
Blood plasma normally shows viscosity only, while whole blood is both viscous and elastic -
CORRECT ANSWER - True
Thixotropy is a comparatively fast recovery of a material of consistency lost due to shearing
stress - CORRECT ANSWER - False
A matter that exhibits plastic flow, below its yield value would behave as - CORRECT
ANSWER - Elastic flow
The arrhenius equation of rheology expresses the relationship between - CORRECT
ANSWER - Viscosity and temperature
Ostwald viscometer is used for - CORRECT ANSWER - liquids that flow relatively easily
Pseudoplatic flow has a yield value - CORRECT ANSWER - False
The key factor in the viscoelasticity of blood are - CORRECT ANSWER - both
aggregation and deformability
1 centipoise is equal to - CORRECT ANSWER - 0.01 poise
If the shearing stress is directly proportional to the rate of shear the liquid exhibits a - CORRECT
ANSWER - Newtonian flow
, Which one of the following facts are correct with respect to thixotropy - CORRECT
ANSWER - Exhibited by shear thinning systems, such as pseudoplastic and plastic liquids
Can be defined as an isothermal and comparatively slow recovery, on standing of a material, of a
consistency lost through shearing
Behavior is useful for many pharmaceutical preps (suspensions)
Which one of the following is the most desirable flow characteristic for a dosage form design -
CORRECT ANSWER - Thixotropic flow
Under which situation will the viscosity of oil increase - CORRECT ANSWER - As
temperature decreases
Viscosity of an unknown liquid is 0.580 cp at 25 degrees celsius and the density is 0.858/cm
cubed. What is the kinematic viscosity of the unknown liquid - CORRECT ANSWER -
0.676 centistrokes
Plastic flow is associated with - CORRECT ANSWER - Suspensions
For Newtonian fluids, if the rate of shear is increased two times from its original value while the
viscosity remains constant. What change could you expect in shearing stress of that liquid -
CORRECT ANSWER - Double it's original value
Thixotropy is a special characteristic that is exhibited by shear thinning systems, such as -
CORRECT ANSWER - Plastic and Pseudoplastic
Polymers in a solution generally exhibit plastic flow - CORRECT ANSWER - False
A solution isoosmotic with blood would be isotonic too - CORRECT ANSWER - False
Molarity of a solution does not depend on temperature of the solution - CORRECT
ANSWER - False
