CODA Exam 3 – Questions With Expert Solutions

CODA Exam 3 – Questions With Expert Solutions

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Terms in this set (114)


Estradiol
Steroidal estrogen
Poor oral bioavailability
Responsible for changes at
puberty
Primary female sex
hormone
Metabolized to estriol and
estrone

Estriol
Steroidal estrogen
Metabolized from estradiol
Less active

Estrone
Steroidal estrogen
Metabolized from estradiol
Less active

Quinestrol
Steroidal estrogen
Pro-drug metabolized to
ethinyl estradiol

Mestranol
Steroidal estrogen
Pro-drug metabolized to
ethinyl estradiol

,Ethinyl estradiol
Steroidal estrogen
Metabolized from
mestranol and quinestrol
Provides oral bioavailability
w/out changing activity
(same activity as estradiol)

Equilin
Steroidal estrogen
Comes from urine of
pregnant mares
Sulfate conjugates -
Premarin
Not as potent as estradiol
or ethinyl estradiol

Diethylstilbestrol (DES)
Non-steroidal estrogen
More potent than estradiol
at stimulating estrogen
receptors
Primarily used to treat
prostate cancer

Clomiphene
Anti-estrogen (SERM)
Fertility agent
Blocks feedback inhibition
of FSH

Fulvestrant (Faslodex)
NOT SERM
Estrogen antagonist
Used to treat estrogen
dependent breast cancer

Anastrozole (Arimidex)
NOT SERM
Aromatase inhibitor
Binds to Aromatase and
blocks the biosynthesis of
estradiol

, Letrozole (Femara)
NOT SERM
Aromatase inhibitor
Binds to Aromatase and
blocks the biosynthesis of
estradiol



Sildenafil (Viagra)
1st marketed PDE5 inhibitor




Vardenafil (Levitra)
PDE5 inhibitor




Tadalafil (Cialis)
PDE5 inhibitor



Aldosterone
Causes Na and water
retention and some K
excretion
Mineralcorticoid
Adrenal cortex

Hydrocortisone
Primary anti inflammatory
-increase lipocortin -->
decrease PLA2
-decrease IL1 & TNFalpha
Glucocorticoid
Regulates intermediary
metabolism
Adrenal cortex
Increase gluconeogenesis
Increase glycogen
deposition in the liver
In equilibrium with
cortisone in plasma