Molecular Biology Exam Questions
and answers graded A+
Palbociclib, Abemaciclib, Flavopiridon, and Ribociclib are used to treat breast cancer and act by:
a. inhibiting cyclins
b. inhibiting cyclin dependent kinases
c. preventing binding of ATP
d. all of the above
e. b and c - ANS✅✅Answer: E
In the Griffith/Avery experiments, which of the following heat killed bacterial extracts did not allow
live non virulent strains to express a polysaccharide capsule?
a. Treated with RNase
b. Treated with proteases
c. Treated with DNase
d. all of the above
e. a and b - ANS✅✅Answer: C
The Central Dogma of molecular biology states that information flows from DNA to RNA to protein
with no exceptions.
True or False - ANS✅✅False
Huntington's Disease is caused by:
a. glutamine expansion of the Huntingtin protein
b. mutations in the HTT gene that add CAG nucleotides
c. aggregation of polyQHtt
d. all of the above
,e. a and b - ANS✅✅Answer: D
Which of the following regarding the P42 peptide is false?
a. prevents aggregation of mutant Huntingtin proteolytic fragments
b. is found near the C-terminus of the normal and mutant forms of Huntingtin
c. interacts with the N-terminal 17 amino acids of Huntingtin
d. all of the above
e. none of the above - ANS✅✅Answer: E
RNA and DNA differ in composition as described by which of the following?
a. RNA contains Uracil
b. DNA lacks a hydroxyl group
c. RNA is held together by phosphoryl diethyl bonds
d. all of the above
e. a and b - ANS✅✅Answer: E
Which of the following concerning proteins is true?
a. Made up of amino acids joined by peptide bonds
b. Made up of nucleosides joined by phosphodiester bonds
c. Made up of amino acids joined by phosphodiester bonds
d. Made up of nucleosides joined by peptide bonds
e. none of the above - ANS✅✅Answer: A
Which of the following concerning prions is false?
a. Strands for proteinaceous infectious only
b. PrPSc is the infectious form created by misfolding of the normal protein
c. the normal form is PrPC
, d. PrPSc binds to PrPC and converts it to an infectious form
e. none of the above - ANS✅✅Answer: E
***Which of the following concerning PrPC is false?
a. Is found in lipid rafts attached via an N terminal GPI anchor
b. Highly conserved in mammals
c. Can be knocked out in mice with no ill effects
d. Binds to AB oligomers which leads to interaction with the co-receptors LRP1 and mGluR5
e. none of the above - ANS✅✅Answer: A or C
(Since this question had two answers, it will be slightly different on the exam)
The N1 peptide of PrPC promotes myelin maintenance by interacting with Adrgr6 receptor on
Schwann cells.
True or False - ANS✅✅True
Specific DNA binding proteins rely on ___________ while nonspecific binding occurs predominantly
via ___________________________.
a. electrostatic/charge interaction; H bonding with bases in the major groove
b. H bonding with bases in the major groove; electrostatic/charge interaction
c. H bonding with bases in the minor groove; H bonding with bases in the major groove
d. all of the above
e. none of the above - ANS✅✅Answer: B
Which of the following concerning SSB is false?
a. Nonspecific DNA-binding protein
b. Interacts with proteins involved in DNA repplication and repair
c. Positively charged C-terminal tail interacts with negatively charged DNA backbone
and answers graded A+
Palbociclib, Abemaciclib, Flavopiridon, and Ribociclib are used to treat breast cancer and act by:
a. inhibiting cyclins
b. inhibiting cyclin dependent kinases
c. preventing binding of ATP
d. all of the above
e. b and c - ANS✅✅Answer: E
In the Griffith/Avery experiments, which of the following heat killed bacterial extracts did not allow
live non virulent strains to express a polysaccharide capsule?
a. Treated with RNase
b. Treated with proteases
c. Treated with DNase
d. all of the above
e. a and b - ANS✅✅Answer: C
The Central Dogma of molecular biology states that information flows from DNA to RNA to protein
with no exceptions.
True or False - ANS✅✅False
Huntington's Disease is caused by:
a. glutamine expansion of the Huntingtin protein
b. mutations in the HTT gene that add CAG nucleotides
c. aggregation of polyQHtt
d. all of the above
,e. a and b - ANS✅✅Answer: D
Which of the following regarding the P42 peptide is false?
a. prevents aggregation of mutant Huntingtin proteolytic fragments
b. is found near the C-terminus of the normal and mutant forms of Huntingtin
c. interacts with the N-terminal 17 amino acids of Huntingtin
d. all of the above
e. none of the above - ANS✅✅Answer: E
RNA and DNA differ in composition as described by which of the following?
a. RNA contains Uracil
b. DNA lacks a hydroxyl group
c. RNA is held together by phosphoryl diethyl bonds
d. all of the above
e. a and b - ANS✅✅Answer: E
Which of the following concerning proteins is true?
a. Made up of amino acids joined by peptide bonds
b. Made up of nucleosides joined by phosphodiester bonds
c. Made up of amino acids joined by phosphodiester bonds
d. Made up of nucleosides joined by peptide bonds
e. none of the above - ANS✅✅Answer: A
Which of the following concerning prions is false?
a. Strands for proteinaceous infectious only
b. PrPSc is the infectious form created by misfolding of the normal protein
c. the normal form is PrPC
, d. PrPSc binds to PrPC and converts it to an infectious form
e. none of the above - ANS✅✅Answer: E
***Which of the following concerning PrPC is false?
a. Is found in lipid rafts attached via an N terminal GPI anchor
b. Highly conserved in mammals
c. Can be knocked out in mice with no ill effects
d. Binds to AB oligomers which leads to interaction with the co-receptors LRP1 and mGluR5
e. none of the above - ANS✅✅Answer: A or C
(Since this question had two answers, it will be slightly different on the exam)
The N1 peptide of PrPC promotes myelin maintenance by interacting with Adrgr6 receptor on
Schwann cells.
True or False - ANS✅✅True
Specific DNA binding proteins rely on ___________ while nonspecific binding occurs predominantly
via ___________________________.
a. electrostatic/charge interaction; H bonding with bases in the major groove
b. H bonding with bases in the major groove; electrostatic/charge interaction
c. H bonding with bases in the minor groove; H bonding with bases in the major groove
d. all of the above
e. none of the above - ANS✅✅Answer: B
Which of the following concerning SSB is false?
a. Nonspecific DNA-binding protein
b. Interacts with proteins involved in DNA repplication and repair
c. Positively charged C-terminal tail interacts with negatively charged DNA backbone
